Activity of staphylococcal bacteriocins against Staphylococcus aureus and Streptococcus agalactiae involved in bovine mastitis

Coelho, Marcus Lívio Varella; Nascimento, Janaı́na dos Santos; Fagundes, Patrícia Carlin; Madureira, Danielle Jannuzzi; Oliveira, Selma Soares de; Brito, Maria Aparecida Vasconcelos de Paiva; Bastos, Maria do Carmo de Freire

doi:10.1016/j.resmic.2007.07.002

Cited by 63 publications

(21 citation statements)

References 28 publications

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“…Problems with decreased therapeutic efficacy and the raise of antibiotic-resistant bacteria in livestock production have stimulated the research for new strategies to control mastitis (Varella Coelho et al 2007;Wu et al 2007). Previous studies indicated that propolis, a complex resinous material produced by honeybees from plant buds, exudates, beeswax, and bee secretions, was effective against S. aureus infections (Sayed et al 2009;Raghukumar et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows

Santana

Barbosa

Ferreira

et al. 2011

World J Microbiol Biotechnol

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Staphylococcus aureus is an important pathogen for both humans and animals, and it has been an ubiquitous etiological agent of bovine mastitis in dairy farms worldwide. Elimination of S. aureus with classic antibiotics is difficult, and the current study aimed to evaluate the efficacy of ethanolic extracts of propolis (EEP) against S. aureus cultivated in complex media or milk. EEP (0-0.5 mg ml(-1)) decreased growth of S. aureus in BHI media and 1 mg ml(-1) was bactericidal against washed cell suspensions (10(7) CFU ml(-1)). Propolis extracts also killed S. aureus cells resuspended in milk, but the bactericidal dose was at least 20-fold greater. Cultures that were transferred for at least 60 generations with sub-lethal doses of propolis did not change much their sensibility to EEP. Atomic force microscopy images revealed changes in morphology and cell size of S. aureus cells exposed to EEP (0.5 mg ml(-1)). Our results indicate that propolis extracts might be effective against mastitis-causing S. aureus strains in vivo, but milk constituents affect the inhibitory activity of propolis. Considering that propolis-resistance appears to be a phenotype not easily selected, the use of EEP combined or not with other antimicrobial agents might be useful for mastitis control in vivo.

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Section: Introductionmentioning

confidence: 99%

Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows

Santana

Barbosa

Ferreira

et al. 2011

World J Microbiol Biotechnol

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“…Different researchers tested bacteriocins produced by staphylococci against more than 200 S. aureus and S. agalactiae isolates from mastitis cases. These studies reported high rates of inhibition by most of the bacteriocins tested, especially when using epidermin and a combination of aureocin A53 and A70 [153]; other S. aureus isolates from cow udders also exhibited activity against pathogenic Bacillus, Listeria and S. aureus strains [154].…”

Section: Bacteriocins and Probiotics In Skin And Soft-tissues Diseasementioning

confidence: 99%

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

Montalbán-López¹,

Sánchez‐Hidalgo²,

Valdivia³

et al. 2011

CPB

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Bacteriocins are ribosomally synthesized (poly)peptides produced by almost all prokaryotic lineages. Bacteriocins from lactic acid bacteria (LAB) and bacteriocin-producer probiotic organisms have been thoroughly studied due to their wide spectra of action, the long-term use in food fermentations and the consideration of these microorganisms as beneficial for human beings. Most of the studies on the biotechnological application of diverse bacteriocins have been focused on their use as food preservatives, nisin being the prototype successfully used in alimentation. However, bacteriocins from LAB have demonstrated a remarkable potential as therapeutics for medical or veterinary uses, alone or in combination with classical antimicrobials. Their interest is even higher now that the resistance to the antibacterials used in therapeutics is growing. In this review we explore exciting opportunities for bacteriocin and probiotic applications, highlighting the possibilities for new and innovative research in order to give the necessary attention to this type of natural molecules that exhibit a great potential.

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“…Aureocin A53 exhibits a broad spectrum of antimicrobial activity (3), being highly bacteriolytic against multidrug-resistant nosocomial staphylococcal strains (4), streptococci, and staphylococci involved in bovine mastitis (5, 6). It also exhibits an activity against strains of the foodborne pathogen Listeria monocytogenes , even in a food matrix, and several features relevant to application in food biopreservation (7).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of the Aureocin A53–Producing Strain Staphylococcus aureus A53

et al. 2016

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Activity of staphylococcal bacteriocins against Staphylococcus aureus and Streptococcus agalactiae involved in bovine mastitis

Cited by 63 publications

References 28 publications

Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows

Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

Draft Genome Sequence of the Aureocin A53–Producing Strain Staphylococcus aureus A53

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