Activity of red dragon fruit (<i>Hylocereus polyrhizus</i>) juices on doxorubicin-induced nephropathy in rats

Prasetyo, Bayu Febram; Shabrina, Hasyyati; Juniantito, Vetnizah; Wientarsih, Ietje

doi:10.1088/1755-1315/196/1/012037

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The similar results were obtained with Hor et al (38) who found that biochemical analysis showed some significant changes, including creatinine, globulin, total protein and urea levels in the sub chronic toxicity study of red Pitaya fruit (Hylocereus polyrhizus). Also, Prasetyo et al (39) found that red Pitaya fruit juice administration can prevent or reduce the effects of doxorubicin (DOX)-induced nephrotoxicity in rats, as evidenced by a decrease in the number of glomerular with protein sediment and necrotic tubular epithelium cells, as well as improved kidney functions. The data presented in table (4) shows the effect of pitaya fruit on liver enzymes (AST, ALT and ALP) of diabetic rats.…”

Section: Resultsmentioning

confidence: 99%

التأثير المحتمل لفاكهة البتايا الحمراء على الفئران المصابه بالداء السكري المستحث بالالوكسان

الشاعر¹,

دياب²,

عبدالا³

2022

مجلة الاقتصاد المنزلي.جامعة المنوفية

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This study aimed to discover pitaya fruit's potential health effects on alloxan-induced diabetic rats. Thirty mature albino rats (140-160 g) were divided into two main groups. The first group (n=5 rats) served as a negative control; the second group (n=25 rats) was injected with alloxan to induce diabetes, then divided into five groups (5 rats each), one of them kept as a positive control group. At the same time, the four left groups were given pitaya flesh juice 5 mg/kg BW., pitaya flesh juice 7.5 mg/kg BW., pitaya peels powder 2.5%, and pitaya peels powder 5%, respectively. The treatment lasted for 28 days. According to the findings, pitaya peel powder of 5 percent reduced serum glucose by 201.52 ±3.01 to 105.46 ±1.33 mg/dl in diabetes mellitus. Pitaya peels powder 5% recorded the highest effects in improving kidney parameters, liver enzymes, lipids profile, and antioxidant enzymes. The results suggested that pitaya flesh juice (5 mg/kg. BW ), pitaya flesh juice (7.5 mg/kg. BW ), pitaya peels powder (2.5%), and pitaya peels powder (5%) might be utilized to improve the health status of diabetes mellitus. According to the findings of this study, pitaya fruit is not only beneficial to the health of diabetic people, but it may also be beneficial to individuals with cardiovascular disease and liver and kidney disease. Pitaya fruit improved the biochemical indicators of diabetic rats and lowered Serum glucose. Therefore it can be considered an important dietary intervention method for diabetics.

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Section: Resultsmentioning

confidence: 99%

التأثير المحتمل لفاكهة البتايا الحمراء على الفئران المصابه بالداء السكري المستحث بالالوكسان

الشاعر¹,

دياب²,

عبدالا³

2022

مجلة الاقتصاد المنزلي.جامعة المنوفية

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“…Red dragon fruit juice administration can prevent or reduce the effects of doxorubicin (DOX)-induced nephrotoxicity in rats, as evidenced by a decrease in the number of glomerular with protein sediment and necrotic tubular epithelium cells, as well as improved kidney functions (Prasetyo et al, 2018).…”

Section: ‫النوعية‬ ‫التربية‬ ‫مجاالت‬ ‫في‬ ‫البحوث‬ ‫مجلة‬mentioning

confidence: 99%

التأثیر المحتمل لثمار فاکهة التنین الأحمر علی الفئران المصابة بارتفاع الکولیسترول

علي¹

2021

مجلة البحوث فی مجالات التربیة النوعیة

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This study was conducted to investigate the effect of different levels of the red dragon (Hylocereus polyrhizus) fruit powder (2%, 4%, 6%) on hypercholesterolemic male albino rats. The study included 30 white male albino rats, weighing about (140 ± 10g), which were divided into (5) equal groups, each group (6) rats, one was kept as control (-ve) group, while the other (4) groups were induced hypercholesterolemic by the injection of Triton-x-100 (100 mg/kg body weight of the rat). Some biochemical analyses including, lipid profiles, atherogenic index (AI), glucose level, liver enzymes, kidney functions and hematological parameters have been determined. Also, the identification of phenolics compounds of the red dragon was done by using the HPLC method. The obtained results indicated that red dragon fruit powder contains different amounts of phenolics compounds, the highest levels recorded for catechin, chlorogenic acid, synergic acid, p-coumaric acid, ferulic acid. Data also showed a significant decrease in liver enzymes, kidney functions, serum glucose level and hematological parameters, lipid profiles (TC, TG, LDL-c, VLDL-c) in all treated groups, as compared to the positive control group, while HDL-c level increased. Therefore, red dragon fruit powder especially with a 6% level improved all tested biochemical analyses and could be considered therapeutic means for the treatment of hypercholesterolemia rats.

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“…betacyanins, are responsible for the typical red color of this fruit and have been demonstrated to exhibit considerable antioxidant activity with potential applications in functional foods [1]. Betacyanins have been reported to provide a number of prominent functional properties such as nephroprotective [2], antioxidant [3], anti-inflammatory [4], and osteoarthritis pain relief [5]. Because of these health-promoting effects, in addition to its exotic red color and pleasing palate, red dragon fruit has attracted global interest over the last decade.…”

Section: Introductionmentioning

confidence: 99%

Optimization by Means of Chemometric Tools of an Ultrasound-Assisted Method for the Extraction of Betacyanins from Red Dragon Fruit (Hylocereus polyrhizus)

et al. 2021

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Betacyanins have been reported to provide prominent health-promoting effects, in addition to contributing to the exotic color and pleasant palate of red dragon fruit that has been attracting universal interest for over a decade. An accurate determination of betacyanins in dragon fruit is important if we are to benefit from the nutraceutical features of these compounds. Seven betacyanin pigments have been identified and extracted by means of ultrasound-assisted techniques from red dragon fruit. Chemometric tools such as Box–Behnken Design (BBD) in conjunction with response surface methodology (RSM) have been successfully used to evaluate and optimize the relevant extraction variables i.e., temperature (A: 10, 35, 60 °C), solvent composition (B: 20, 50, 80% methanol in water), sample to solvent ratio (C: 0.1:10, 0.2:10, 0.3:10 g/mL), power (D: 20, 45, 70%), and cycle (E: 0.3, 0.5, 0.7 s−1). The results obtained from the analysis of variance (ANOVA) suggest that the solvent composition (p 0.0063), sample to solvent ratio (p 0.0126), and cycle (p 0.0302) are the most influential variables in betacyanin extraction. The optimal variable settings for ultrasound-assisted extraction (UAE) were a 54.6 °C extraction temperature, 0.3 s−1 cycle, 20% ultrasound power, 21.4% methanol in water solvent composition, 0.2:10 sample to solvent ratio, and a 5 min extraction time. The validation of the method for repeatability and intermediate precision provided excellent results at 1.56% and 2.94% respectively. Furthermore, the novel UAE method was successfully used for the determination of betacyanins content in red dragon fruit from different geographic origins.

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Activity of red dragon fruit (Hylocereus polyrhizus) juices on doxorubicin-induced nephropathy in rats

Cited by 3 publications

References 9 publications

التأثير المحتمل لفاكهة البتايا الحمراء على الفئران المصابه بالداء السكري المستحث بالالوكسان

التأثير المحتمل لفاكهة البتايا الحمراء على الفئران المصابه بالداء السكري المستحث بالالوكسان

التأثیر المحتمل لثمار فاکهة التنین الأحمر علی الفئران المصابة بارتفاع الکولیسترول

Optimization by Means of Chemometric Tools of an Ultrasound-Assisted Method for the Extraction of Betacyanins from Red Dragon Fruit (Hylocereus polyrhizus)

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