Activity of olive leaf extracts against the promastigote stage of Leishmania species and their correlation with the antioxidant activity

The therapeutic effects of olive leaf extract on Leishmania major infection in BALB/c mice

“…Previously, Sifaoui et al (2014) reported that the inhibitory effect of some Tunisian olive tree varieties against the promastigote stage of L. donovani, L. tropica, L. major and L. amazonensis with IC 50 ranging from 2.1 to 71.5 μg/ml [20]. Despite the number of papers published on olive leaf and its antileishmanial effects, none of them has focused on in vivo efficacy OLE on cutaneous leishmaniasis in a mouse model of infection.…”

“…There are several studies which indicate polyphenols potentially inhibit amastigote and promastigote forms of different species of Leishmania species [24,25]. In addition, Sifaoui et al (2014) showed that the relative leishmanicidal activity of five varieties against L. tropica and L. major was moderately correlated to phenols and flavonoids content [20]. Flavonoids are also broad classes of plant phenolics that have been under study for antiparasitic activity [26].…”

“…Flavonoids are also broad classes of plant phenolics that have been under study for antiparasitic activity [26]. Regarding antileishmanial activity of triterpenic acid several studies have been done [20,27] Moreover, in several investigations antimicrobial and antiviral effects of oleuropein against some pathogenic bacterial and viral strains have been proven [31]. Therefore, phytoconstituents in this plant particularly oleuropein could be answerable for the antileishmanial activity of OLE but their accurate mechanism of ac tion is vague.…”

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“…On the subject of antileishmanial effects of triterpenic acids has been shown in numerous investigations 23,30 . For instance, Torres-Santos et al, (2014) confirmed that oleanolic acid, ursolic acid and triterpenic acids extracted from the Pourouma guianensis demonstrate considerable effects against L. amazonensis 30 .…”

“…This difference in the vulnerability of two forms could be linked to their biochemical, structural, and morphological factors 16 . Sifaoui et al, (2014) have demonstrated the repressive effect of some Tunisian olive species on the promastigote forms of some Leishmania spp with IC 50 varing from 2.1 to 71.5 μg/ml 23 .…”