Activity of metalloproteinases and adiponectin in obese patients— a possible factor of incisional hernias after bariatric procedures

Szczęsny, Wojciech; Kuligowska-Prusińska, Magdalena; Dąbrowiecki, Stanisław; Szmytkowski, Jakub; Reśliński, Adrian; Słupski, Maciej

doi:10.1631/jzus.b1600383

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…In obesity, adipogenesis undergoes dynamic remodeling, which is related to the turnover of ECM components [115]. In obese states, serum concentrations of MMP-2 and MMP-9 are elevated [116].…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Role of Leptin and Adiponectin in Carcinogenesis

Bocian-Jastrzębska,

Malczewska-Herman,

Kos-Kudła

2023

Cancers

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Hormones produced by adipocytes, leptin and adiponectin, are associated with the process of carcinogenesis. Both of these adipokines have well-proven oncologic potential and can affect many aspects of tumorigenesis, from initiation and primary tumor growth to metastatic progression. Involvement in the formation of cancer includes interactions with the tumor microenvironment and its components, such as tumor-associated macrophages, cancer-associated fibroblasts, extracellular matrix and matrix metalloproteinases. Furthermore, these adipokines participate in the epithelial–mesenchymal transition and connect to angiogenesis, which is critical for cancer invasiveness and cancer cell migration. In addition, an enormous amount of evidence has demonstrated that altered concentrations of these adipocyte-derived hormones and the expression of their receptors in tumors are associated with poor prognosis in various types of cancer. Therefore, leptin and adiponectin dysfunction play a prominent role in cancer and impact tumor invasion and metastasis in different ways. This review clearly and comprehensively summarizes the recent findings and presents the role of leptin and adiponectin in cancer initiation, promotion and progression, focusing on associations with the tumor microenvironment and its components as well as roles in the epithelial–mesenchymal transition and angiogenesis.

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Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Role of Leptin and Adiponectin in Carcinogenesis

Bocian-Jastrzębska,

Malczewska-Herman,

Kos-Kudła

2023

Cancers

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“…The European Research Journal Volume 8 Issue 3 May 2022 no metabolic disorders as well as normal body weight. Derosa et al [19], and other studies established a link between MMP-9 and body weight parameters in individuals with severe obesity before to and after bariatric surgery [34][35][36].…”

mentioning

confidence: 92%

Pathophysiology of metalloproteinase matrix in relation to morbid obesity and associated pathologies

Mirică

Ionescu

Ginghină

et al. 2022

The European Research Journal

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Matrix Metalloproteinases (MMPs), these calcium-dependent zinc-containing endopeptidases play an important role in adipogenesis and angiogenesis by modifying tissues and degrading the extracellular matrix (ECM). Matrix glycoproteins, gelatin, collagens, proteoglycans and elastin are all found in the ECM. Current meta-analysis confirmed the lower levels of IL-6 and CRP was found following bariatric surgery. Several studies have shown correlations between E-selectin levels, BMI, and MMP-9 levels. There was also a strong link between the metalloproteinases MMP-2 and MMP-9. MMP-2 and adiponectin levels are related. MMP-9 levels, on the other hand, were modestly linked with E-selectin and HDL cholesterol levels, as previously stated. Also current observations imply that alterations in the ECM caused by MMP-mediated degradation may be crucial for the differentiation of adipocytes. The most crucial component of this is that MMPs are involved in the remodeling of tissue after gastric bypass surgery, as revealed by these markers (especially MMP-2 and MMP-9). Thus, it is tempting to assume that adipocyte derived MMPs may constitute a novel pharmaceutical target for limiting adipose tissue development through the reduction of adipocyte differentiation and angiogenesis. MMP-2 exhibits far more accurate oscillations than MMP-9 during pre- and post-surgical weight fluctuations, and hence may be used as a predictor for gastric bypass success. The purpose of this paper is to conduct a comprehensive review of the literature with an emphasis on the critical functions that MMPs have in the pathophysiology of obesity and the related diseases.

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Body mass index and the risk of abdominal hernia: a Mendelian randomization study

Xia

et al. 2022

Hernia

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Activity of metalloproteinases and adiponectin in obese patients— a possible factor of incisional hernias after bariatric procedures

Abstract: The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.

Cited by 4 publications

References 35 publications

Role of Leptin and Adiponectin in Carcinogenesis

Role of Leptin and Adiponectin in Carcinogenesis

Pathophysiology of metalloproteinase matrix in relation to morbid obesity and associated pathologies

Body mass index and the risk of abdominal hernia: a Mendelian randomization study

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