Body mass index and the risk of abdominal hernia: a Mendelian randomization study

Li, Zhenqi; Xia, Lu; Li, X.; Guan, Yunfei; He, Hongyang; Jin, Liquan

doi:10.1007/s10029-022-02703-w

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Although some inconsistencies have arisen regarding the relationship between BMI and inguinal hernia in Mendelian randomization analyses 41,42 , we maintain con dence in our results' repeated validation and reliability.…”

Section: Discussionsupporting

confidence: 61%

Exploring Obesity Management as a Novel Approach for Preventing Inguinal Hernias: Evidence from a Mendelian Randomization Study and Systematic Review

Deng,

Zhou,

Zhang

et al. 2024

Preprint

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Background: The relationship between obesity and the risk of developing inguinal hernias (IH) is still unclear. This study aimed to examine the role of different types of obesity in IH risk, with the potential for obesity management as a new approach to preventing IH. Methods: A two-sample Mendelian randomization (MR) analysis and replicated MR analysis were conducted to assess the causal effect of obesity on IH risk. Summary data on genetically determined obesity-related traits, including body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR), were collected from large-scale consortia. Multivariable MR was performed to estimate the independent effects on IH risk. Additionally, a systematic review of observational studies identified from PubMed, Embase, and Web of Science databases was conducted to evaluate the associations between different obesity types and IH, covering the period from inception to November 22, 2023. Results: The findings revealed that increased BMI, WC, and HC (P < 0.05) were associated with a lower risk of IH. The replicated and multivariable MR analyses consistently indicated that BMI exhibited a similar direction and magnitude of effect as observed in the univariable MR analysis [odds ratio (OR) = 0.940-0.989], while WC was associated with a higher risk of IH (OR = 1.018-1.099). The systematic review results supported BMI as a protective factor against inguinal hernia. However, there was limited evidence supporting the causal role of HC and WHR in IH risk. Conclusion: Genetically determined BMI and WC demonstrate a causal relationship with IH risk, providing new insights into potential underlying mechanisms. These results suggest that increasing overall or reducing abdominal obesity may be beneficial for preventing IH.

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Section: Discussionsupporting

confidence: 61%

Exploring Obesity Management as a Novel Approach for Preventing Inguinal Hernias: Evidence from a Mendelian Randomization Study and Systematic Review

Deng,

Zhou,

Zhang

et al. 2024

Preprint

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“…Nowadays, the prevalence of obesity has surged worldwide posing new challenges for surgeons due to the increasing number of VH patients associated with obesity. Previous studies only focused on the relationship between body mass index (BMI) and VH 5,6 . However, in recent years, scholars proposed that although BMI is an important risk factor for VH, it cannot differentiate between abdominal subcutaneous, visceral, and peripheral adiposity 7,8 .…”

Section: Introductionmentioning

confidence: 99%

“…Obesity is a recognized risk factor for VH, with a causal relationship established between obesity and a higher risk of VH. 5 Nowadays, the prevalence of obesity has surged worldwide posing new challenges for surgeons due to the increasing number of VH patients associated with obesity. Previous studies only focused on the relationship between body mass index (BMI) and VH.…”

mentioning

confidence: 99%

“…Previous studies only focused on the relationship between body mass index (BMI) and VH. 5,6 However, in recent years, scholars proposed that although BMI is an important risk factor for VH, it cannot differentiate between abdominal subcutaneous, visceral, and peripheral adiposity. 7,8 Evidence of these observational studies was based on small sample sizes and therefore might not fully confirm the causal relationship between adiposity distribution and VH.…”

mentioning

confidence: 99%

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Causal relationship of obesity and adiposity distribution on risk of ventral hernia

Shi,

Wu,

Guo

et al. 2024

World j. surg.

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PurposeVentral hernia (VH) is a common surgical disease. Previous studies suggested that obesity is an important risk factor for VH. However, the causal relationship between fat distribution and the risk of VH is still unclear. This study used Mendelian randomization (MR) to evaluate their causal relationship.MethodsWe used the body mass index (BMI), body fat percentage, and body fat mass to represent general obesity and utilized the volume of abdominal subcutaneous adiposity tissue, visceral adiposity tissue, waist circumference, hip circumference, and waist‐to‐hip ratio to represent abdominal adiposity. The data were extracted from the large‐scale genome‐wide association study of European ancestry. We used two‐sample MR to infer causality, using multivariate MR to correct the effects of confounding factors.ResultsIncreased BMI, body fat percentage, body fat mass, visceral adiposity tissue, waist circumference, and hip circumference rather than subcutaneous adiposity tissue or waist‐to‐hip ratio, were causally associated with a higher risk of VH. The results of multivariate MR suggested that body fat percentage was causally associated with a higher risk of VH after adjusting for body mass index, diabetes, and smoking.ConclusionGeneral obesity, increased visceral adiposity tissue, waist circumference, and hip circumference rather than subcutaneous adiposity tissue or the waist‐to‐hip ratio were causally associated with a higher risk of VH. These findings provided a deeper understanding of the role that the distribution of adiposity plays in the mechanism of VH.

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Comment to: An evidence map and synthesis review with meta-analysis on the risk of incisional hernia in colorectal surgery with standard closure

2022

Hernia

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Body mass index and the risk of abdominal hernia: a Mendelian randomization study

Cited by 5 publications

References 34 publications

Exploring Obesity Management as a Novel Approach for Preventing Inguinal Hernias: Evidence from a Mendelian Randomization Study and Systematic Review

Exploring Obesity Management as a Novel Approach for Preventing Inguinal Hernias: Evidence from a Mendelian Randomization Study and Systematic Review

Causal relationship of obesity and adiposity distribution on risk of ventral hernia

Comment to: An evidence map and synthesis review with meta-analysis on the risk of incisional hernia in colorectal surgery with standard closure

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