Activity of mesenchymal stem cells in therapies for chronic skin wound healing

Nuschke, Austin

doi:10.4161/org.27405

Cited by 144 publications

(125 citation statements)

References 116 publications

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“…MSC treatment promotes different stages of the wound repair process. 7 New studies with cell-based therapies to treat venous leg ulcers, diabetic foot ulcers, and pressure ulcers-the three main types of chronic wounds-are a major effort. However, there are some potential limitations to successful MSC therapy, and further research is needed.…”

Section: Clinical Relevancementioning

confidence: 99%

See 1 more Smart Citation

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Otero-Viñas

Falanga

2016

Advances in Wound Care

115

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Section: Clinical Relevancementioning

confidence: 99%

“…94 In addition, due to MSC properties of immunosuppression and promotion of angiogenesis, this cell therapy approach shows promise. 7 …”

mentioning

confidence: 99%

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Otero-Viñas

Falanga

2016

Advances in Wound Care

115

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“…(2) The inflammatory phase is initiated by neutrophil migration to the wound site as a result of stimulation by various chemoattractant molecules, such as tumor necrosis factor-α (TNF-α) or interleukin-1 (IL-1). The proliferative phase is marked by an increase in a number of growth factors, such as vascular endothelial growth factor (VEGF).…”

Section: Introductionmentioning

confidence: 99%

“…(3,4) The increase of these molecules may stimulate fibroblast proliferation that results in increased collagen synthesis, in addition to angiogenesis. (1)(2)(3) Several studies report that mesenchymal stem cells (MSCs) play an important role in wound healing, particularly in the inflammatory phase, because of their immunoregulatory characteristics, so that they are able to control the inflammatory process. (5) Mesenchymal stem cells are adult stem cells with the characteristics of adhering to plastic culture dishes, having various surface markers, such as CD73(+), CD90(+), CD105(+), CD45(-), CD34(-), CD14(-) or CD11 (-), CD79(-) or CD19 (-) and HLA-DR(-), (6) and being able to differentiate into various cells, such as neurons and adipocytes.…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor-α-activated mesenchymal stem cells accelerate wound healing through vascular endothelial growth factor regulation in rats

Nugraha

Putra

2018

Universa Medicina

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Background Wounds are areas of physical or thermal damage of the epithelial layer of skin or mucosa. The wound healing process consists of hemostasis, inflammation, proliferation, and remodeling. Mesenchymal stem cells (MSCs) play a role in wound healing by suppressing potent pro-inflammatory molecules, such as tumor necrosis factor-α (TNF-α), leading to macrophage polarization from the pro-inflammatory type to the pro-regeneration type characterized by increasing vascular endothelial growth factor (VEGF) production. MSCs are able to increase VEGF level in-vivo correlated with collagen synthesis. The objective of this study was to assess the role of TNF-α-activated MSCs on VEGF in rat wounds. Methods An experimental animal study with post-test only control group design was performed involving 24 Wistar rats. The rats were randomized into four groups consisting of one control (K) and three treatment groups (P) (activated MSCs at doses of 3x105, 6x105, and 12x105 cells, respectively). The measurement of VEGF levels was done using ELISA assay while the collagen analysis was performed by light microscopy. One way ANOVA and Post Hoc LSD were used to analyze the data. Results The results showed a significant increase in VEGF levels (p <0.05) on day 3 and then a significant decrease on day 5 along with a significant increase in the amount of collagen on day 7 (p<0.05). Conclusion This study demonstrated that TNF-α-activated MSCs were able to regulate VEGF levels and collagen synthesis in wound healing in rats. The molecular mechanism by which TNF-α-activated MSCs stimulate cutaneous wound healing should be clarified further.

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“…Furthermore, they demonstrate suboptimal engraftment, survivability, and retention at the wound when transplanted, 85,86 with several of the underlying mechanisms discussed previously. Many studies rely on intradermal or intramuscular injection to administer stem cells in suspension.…”

Section: Improving Stem Cell Yield Efficacy and Lifespan -Current Amentioning

confidence: 92%

Stem cells and chronic wound healing: state of the art

Leavitt¹,

Hu²,

Barnes³

et al. 2016

CWCMR

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Currently available treatments for chronic wounds are inadequate. A clearly effective therapy does not exist, and treatment is often supportive. This is largely because the cellular and molecular processes underlying failure of wound repair are still poorly understood. With an increase in comorbidities, such as diabetes and vascular disease, as well as an aging population, the incidence of these intractable wounds is expected to rise. As such, chronic wounds, which are already costly, are rapidly growing as a tremendous burden to the health-care system. Stem cells have garnered much interest as a therapy for chronic wounds due to their inherent ability to differentiate into multiple lineages and promote regeneration. Herein, we discuss the types of stem cells used for chronic wound therapy, as well as the proposed means by which they do so. In particular, we highlight mesenchymal stem cells (including adipose-derived stem cells), endothelial progenitor cells, and induced pluripotent stem cells. We include the results of recent in vitro and in vivo studies in both animal models and human clinical trials. Finally, we discuss the current studies to improve stem cell therapies and the limitations of stem cell-based therapeutics. Stem cells promise improved therapies for healing chronic wounds, but further studies that are well-designed with standardized protocols are necessary for fruition.

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Activity of mesenchymal stem cells in therapies for chronic skin wound healing

Cited by 144 publications

References 116 publications

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Tumor necrosis factor-α-activated mesenchymal stem cells accelerate wound healing through vascular endothelial growth factor regulation in rats

Stem cells and chronic wound healing: state of the art

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