Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2

Six pentacyclic triterpenes were isolated from hexane extract of stems of Maytenus salicifolia Reissek, Celastraceae: 30-hydroxyfriedelan-3-one (1), 3,16-dioxofriedelane (2), friedeline (3), lupeol (4), betuline (5) and lup-20(29)-en-3,30-diol (6). The structure each one was established on the basis of detailed 1 H and 13 C NMR spectral investigation and by comparison with the respective literature values. For compound 1, the complete 2D NMR (HMBC, HMQC and NOESY) spectral data were herein reported for the first time. Compounds 1, 2, 5 and 6 were isolated for the first time from this plant. Antioxidant activity is described for some extracts from species of the Celastraceae family, then, the extracts from aerial parts of M. salicifolia were evaluated in relation to antioxidant potential using the DPPH method. Compared to quecertin, the AcEt extract (EAF) from leaves, AcEt (EAPF) and MeOH (EMPF) from pulp fruit and AcEt (EAT) and MeOH (EMT) from stems showed significant antioxidant property.

Section: Introductionmentioning

confidence: 99%

Maytenus salicifolia Reissek, Celastraceae: triterpenes isolated from stems and antioxidant property of extracts from aerial parts

Magalhães¹,

Ferrari²,

Guimarâes³

et al. 2011

“…In our research group, we have previously reported several lupane triterpenoids from Maytenus species as being of interest as inhibitors of nitric oxide and prostaglandin E2, as well as possessing antimicrobial and cytotoxic activities (Núñez et al, 2005: Reyes et al, 2006 …”

Section: Resultsmentioning

confidence: 99%

Phytochemical profile of the stems of Aeonium lindleyi

Kennedy¹

2012

Aeonium species are plants rich in phenols and terpenoids and have been widely used in the Canary folk medicine. Following our project concerning bioactive compounds from Macaronesian region, a phytochemical study was carried out to investigate the constituents of the stems of Aeonium lindleyi Webb & Berthel.,Crassulaceae. Air dried and chopped stems of this plant were extracted with ethanol in a Soxhlet apparatus and the total extract was chromatographed on silica gel to afford sixteen known compounds including, one sterol, four lupane triterpenes and eleven phenolic compounds. Their structures were elucidated by means of 1 H-and 13 C-NMR spectroscopic studies and comparison of their spectral data with values in the literature. Both group of isolated metabolites are known by their diverse biological activities and they have been described as antioxidant, cytotoxic, anti-inflammatory. Our results contribute to the knowledge of A. lindleyi as a potential source of bioactive compounds.

“…Plantas do gênero Maytenus são ricas em terpenos da classe dos tripernos (Shirota et al, 1994;Niero et al, 2006;Reyes et al, 2006;Gutieerrez et al, 2007), embora também tenham sido encontrados flavonóides (Sannomiya et al, 1998;Xie et al, 2007;Tiberti et al, 2007), glicolipídios (Mendes et al, 2006) e alcalóides (Corsino et al, 1998 . O extrato etanólico bruto, que anteriormente não apresentava atividade antimicrobiana contra a bactéria P. aeruginosa (BAC -135), apresentou, após fracionamento, atividade positiva para todas as frações obtidas, excetuando-se a hexânica (Tabela 3).…”

Section: Resultsunclassified

“…O gênero Maytenus é formado por espécies arbustivas ou arbóreas encontradas em matas e campos (Barroso, 1991;Joly, 1993) que são largamente utilizadas pelos povos da América do Sul. As plantas desse gênero são ricas em metabólitos bioativos da classe dos terpenos ou isoprenóides (Shirota et al, 1994;Niero et al, 2006;Reyes et al, 2006;Gutieerrez et al, 2007) e atividades biológicas tais como antiinflamatória (Sanogo et al, 2006;Reyes et al, 2006;Santos et al, 2007;Sosa et al, 2007), antiulcerogênica (Mota et al, 2008), antimalaria (Muregi et al, 2007;Muthaura et al, 2007), antioxidante (Brunni et al, 2006;Buffa et al, 2004;Vellosa et al, 2006), antinoceptiva (Niero et al, 2006;Sanogo et al, 2006), antitumoral (Shirota et al, 1994;Buffa et al, 2004) e anticonvulsivante (Quintans-Júnior et al, 2008) já foram relatadas para diversas espécies desse gênero.…”

Section: Introductionunclassified

Perfil fitoquímico e ensaio microbiológico dos extratos da entrecasca de Maytenus rigida Mart. (Celastraceae)

Estevam¹,

Cavalcanti²,

Cambuí³

et al. 2009

"Phytochemistry and microbiological assay of the bark extracts of Maytenus rigida Mart. (Celastraceae)". Maynetus rigida Mart (Celastraceae), known as "Bom-homem", "Bom-nome", "Cabelo-de-negro", "Casca-grossa" and "Pau-de-colher", is a small tree. The stem bark is used by the population in the northeast of Brazil to treat aches, infections and inflammations in general. The present work evaluated both the phytochemistry of M. rigida Mart by an analytical routine, and the antimicrobial activity of the bark extracts by the KirbyBauer modified method. Our results showed the aqueous, methanol, chloroform, ethyl acetate and hydroalcoolic extracts of M. rigida Mart has antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, while the hexane extract does not have any activity. Catechins, quinones, steroids, triterpenes, saponins, flavonoids and phenolic compounds were detected by the phytochemical analysis.