Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma

Bogdanović, Višnja; Tursijan, Slavica; Djordjevic, Milan; Nikolić, Aleksandra; Mrdjanović, Jasminka; Jakimov, Dimitar; Trajković, V.; Bogdanovic, Gordana; Ivković-Kapicl, Tatjana; Dugandžija, Tihomir

doi:10.2298/aoo0804039b

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…Studies have shown that SOD activity was augmented in the early stages of the disease; therefore, it can be used as a marker for the diagnosis of breast cancer (Bogdanović et al, 2008).…”

Section: Oxidative Stress and Breast Cancermentioning

confidence: 99%

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

150

108

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Oxidative stress is caused by an imbalance in the redox status of the body. In such a state, increase of free radicals in the body can lead to tissue damage. One of the most important species of free radicals is reactive oxygen species (ROS) produced by various metabolic pathways, including aerobic metabolism in the mitochondrial respiratory chain. It plays a critical role in the initiation and progression of various types of cancers. ROS affects different signaling pathways, including growth factors and mitogenic pathways, and controls many cellular processes, including cell proliferation, and thus stimulates the uncontrolled growth of cells which encourages the development of tumors and begins the process of carcinogenesis. Increased oxidative stress caused by reactive species can reduce the body's antioxidant defense against angiogenesis and metastasis in cancer cells. These processes are main factors in the development of cancer. Bimolecular reactions cause free radicals in which create such compounds as malondialdehyde (MDA) and hydroxyguanosine. These substances can be used as indicators of cancer. In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals.

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“…Studies have shown that SOD activity was augmented in the early stages of the disease; therefore, it can be used as a marker for the diagnosis of breast cancer (Bogdanović et al, 2008).…”

Section: Oxidative Stress and Breast Cancermentioning

confidence: 99%

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

150

108

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“…Nearly 50% of BC patients will develop distant metastasis, and at some point, more than half patients with metastatic BC will have liver involvement [6]. An increased rate of metabolic changes like anaerobic glycolysis and oxidative stress results in a rapid turnover of cancer cells that modulates the enzyme level in blood circulation [7].…”

Section: Introductionmentioning

confidence: 99%

“…LDH activity correlates with tumor burden, and the metastatic BC exhibits elevated LDH level than normal breast tissue [7]. Gamma Glutamyl transpeptidase (GGT) is an enzyme of glutathione metabolism, involved in cell's detoxification pathway and apoptotic balance-including tumor development, progression and chemotherapy resistance [9,10].…”

Section: Introductionmentioning

confidence: 99%

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Basnyat¹,

Jha²,

Pathak³

et al. 2017

JTLS

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Breast cancer (BC) is the most common type of cancer worldwide, being one of the leading causes of morbidity in the female. In Nepal, it is the second most common type of cancer among women of perimenopausal age group. More than one-quarter of the BC is diagnosed in young Nepalese female, with a familial history of breast cancer, early pregnancy, longer lactation and estrogen exposure, often tumors showing aggressive biological behaviors. Anthracyclines (Doxorubicin) based treatment regime were reported to cause cardiotoxicity by increasing intramyocardial free radical production, lipid alterations and decreasing antioxidant level. Oxidative stress involving cellular reactive oxygen species (ROS) production is widely accepted mechanism, but the molecular basis of chemotherapyinduced organ toxicity remains highly controversial. An increased rate of metabolism and oxidative stress results in rapid turnover of cancer cells that modulates the enzyme level in blood circulation. Serum LDH and GGT level correlate with tumor burden, the metastatic character of BC and intensity of organtoxicity. The aim of our study is to evaluate the serum level of LDH and GGT in BC patients receiving chemotherapy and correlate these enzyme levels with different stages of BC. A total number of 150 subjects were included in the study, comprising 90 histopathologically confirmed 24 to 76 years aged patients of different breast cancer stages, receiving at least 3 cycles of 5-Fluorouracil, Adriamycin, and Cyclophosphamide (FAC) chemotherapy. Sixty age-matched healthy women were enrolled as controls. Blood samples from each were collected after informed consent and analyzed for serum LDH and GGT levels using standard biochemical methods. Data were analyzed using student's paired-T test, Pearson correlation test and ANOVA. Serum LDH and GGT levels were significantly (p < 0.001) increased in BC patients as compared to control group. When all 4 stages of BC were compared to control group, LDH and GGT activities showed a progressive increase from stage I to IV. The study concludes that serum LDH and GGT may be sensitive, specific and profitable biomarkers in early diagnosis of breast cancer, assessing cancer prognosis and response to treatment.

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“…(13) Reported that patient of early carcinoma breast had normal values of Serum Lactate dehydrogenase and only in one patient of stage III b the value of Lactate dehydrogenase was raised by 2 folds. The mean LDH was 6.73 ukat/L (402.99 IU/L) in his study which nearby correlates to our present study in which the mean LDH in early stage is 482.75 IU/L.…”

Section: Resultsmentioning

confidence: 99%

Serum Lactate Dehydrogenase as a Pr Ognostic Marker in Breast Cance R

Tanna¹,

Bakane²

2015

jemds

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BACKGROUND: Breast cancer a multifactorial disease and one of the most dreaded of human diseases that claims the lives of thousands of women all over the globe every year. This may probably due to the fact that it remains undiagnosed at an early stage perhaps due to lack of awareness amongst the females and the fact that most cancers do not produce any symptoms until the tumour are too large to be removed surgically. Hence there is need to detect cancer at an early stage. AIM: Estimation of diagnostic importance and prognostication of serum Lactate dehydrogenase in cases on breast cancer. SETTINGS AND DESIGN: An observational study was conducted in Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha which included 44 confirmed cases of carcinoma breast and 44 normal healthy females admitted in AVBRH in a span of 2 years. METHODS AND MATERIAL: Determination of serum LDH was done using TC matrix analyser. The values of LDH were obtained on presentation, 21 days after intervention, 2 months after intervention and 6 months after intervention. The values of LDH on presentation in both the groups were compared. The decline in the values of LDH were observed with the due course of treatment. Chisquare test and Student's Unpaired and paired t test were used for statistical analysis. RESULT: The mean Lactate dehydrogenase on presentation was in study group and control group was 564.38±219.41 IU/L and 404.18±101.32 IU/L respectively (p<0.05). The levels of Lactate dehydrogenase decreased with due course of treatment. The levels of LDH were proportionate to the stage of disease. CONCLUSION:The results of the study concludes cost effective usefulness of serum Lactate dehydrogenase in early detection of breast cancer and to assess its prognostic importance which can be done in smaller laboratories. The traditional model of DS- HOW TO CITE

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Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma

Cited by 6 publications

References 23 publications

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Serum Lactate Dehydrogenase as a Pr Ognostic Marker in Breast Cance R

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