Activity of eugenol derivatives against Fusarium graminearum Q1 strain and screening of isoeugenol mixtures

Cui, Wen; Du, Kaiyue; Ling, Yu-Xuan; Yang, C. M.

doi:10.1007/s42161-021-00875-5

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…By detecting the sensitivity of 59 F. graminearum strains to thymol, the EC 50 values of thymol of these strains were 22.53-51.76 µg/mL, and the average value was 26.3 µg/mL [11]. In this study, the EC 50 of thymol against F. graminearum was 40 µg/mL, compared with the EC 50 of eugenol and its derivatives of 395.7-1163.9 µM, indicating that the sensitivity of F. graminearum to eugenol is lower than thymol [35]. Thymol can also be used in combination, such as cinnamaldehyde and carvacrol, as a synergist to enhance antifungal activity [36] and reduce the production of trichothecenes by 95-99% [24].…”

Section: The Effect Of Thymol On the Growth Of Myceliummentioning

confidence: 55%

Transcriptomics Reveals the Effect of Thymol on the Growth and Toxin Production of Fusarium graminearum

Wang

Yang

et al. 2022

Toxins

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Fusarium graminearum is a harmful pathogen causing head blight in cereals such as wheat and barley, and thymol has been proven to inhibit the growth of many pathogens. This study aims to explore the fungistatic effect of thymol on F. graminearum and its mechanism. Different concentrations of thymol were used to treat F. graminearum. The results showed that the EC50 concentration of thymol against F. graminearum was 40 μg/mL. Compared with the control group, 40 μg/mL of thymol reduced the production of Deoxynivalenol (DON) and 3-Ac-DON by 70.1% and 78.2%, respectively. Our results indicate that thymol can effectively inhibit the growth and toxin production of F. graminearum and cause an extensive transcriptome response. Transcriptome identified 16,727 non-redundant unigenes and 1653 unigenes that COG did not annotate. The correlation coefficients between samples were all >0.941. When FC was 2.0 times, a total of 3230 differential unigenes were identified, of which 1223 were up-regulated, and 2007 were down-regulated. Through the transcriptome, we confirmed that the expression of many genes involved in F. graminearum growth and synthesis of DON and other secondary metabolites were also changed. The gluconeogenesis/glycolysis pathway may be a potential and important way for thymol to affect the growth of F. graminearum hyphae and the production of DON simultaneously.

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Section: The Effect Of Thymol On the Growth Of Myceliummentioning

confidence: 55%

Transcriptomics Reveals the Effect of Thymol on the Growth and Toxin Production of Fusarium graminearum

Wang

Yang

et al. 2022

Toxins

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“…The mycelial growth rate method was used to measure the antifungal activity [38] . The strains were stored at 4 °C.…”

Section: Methodsmentioning

confidence: 99%

“…The mycelial growth rate method was used to measure the antifungal activity. [38] The strains were stored at 4 °C. The pathogenic fungi were cultured in potato dextrose agar (PDA) media at 26 °C after activation.…”

Section: Antifungal Activity On Fusarium Graminearummentioning

confidence: 99%

Fabrication and Characterization of Zein/PDADMAC Nanoparticles to Encapsulate Tebuconazole by Antisolvent Precipitation Method**

Liu,

Shi,

et al. 2023

ChemistrySelect

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In order to improve the sustained release effect and antifungal activity of tebuconazole (TEB), zein /poly dimethyl diallyl ammonium chloride (PDADMAC) nanoparticles (NPs) were prepared in this study. The hollow zein NPs were made by anti‐solvent precipitation method in which sodium carbonate was chosen as sacrificial template, and PDADMAC was combined with zein NPs via electrostatic self‐assembly after loading TEB. The NPs were characterized through particle size, Zeta potential, scanning electron microscopy (SEM), sustained release effect, contact angle, encapsulation efficiency (EE), loading efficiency (LE) and antifungal activity. In this study, TEB/zein/PDADMAC NPs were stable for at least 28 days at room temperature. The release of TEB showed lower release in NPs compared with technical concentrate (TEB TC, 98 %). In addition, NPs also significantly influenced performance such as wetting performance and antifungal activity. The developed functional TEB/zein/PDADMAC NPs with excellent properties can be promising for antifungal pesticide applications.

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“…EC 50 (ob) represents the actual EC 50 , EC 50 (th) represents the theoretical EC 50 , A and B are single agents, and a and b are the mass ratios of the two in the mixture. SR = 0.5-1.5 is additive, SR < 0.5 is antagonistic and SR > 1.5 is synergistic [30].…”

Section: Seed Coating Formulation Screening and Coating Treatmentmentioning

confidence: 99%

Use of Lentinan and Fluopimomide to Control Cotton Seedling Damping-Off Disease Caused by Rhizoctonia solani

et al. 2022

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Lentinan (LNT) is a natural and functional polysaccharide isolated from Lentinus edodes fruiting bodies, which functions in stimulating the plant immune response, improving plant disease resistance and regulating plant growth. This study explores the use of LNT as a plant growth regulator and attractant in cotton production. After treatment with LNT, the content of malondialdehyde (MDA) in cotton seeds decreased, whereas the activities of polyphenol oxidase (PPO), superoxide dismutase (SOD) and peroxidase (POD) in leaves increased significantly. LNT also promoted the growth and development of cotton plants and significantly reduced the incidence of cotton damping-off disease. The relative expression of salicylic acid pathway-related genes in cotton also increased significantly. The prevention mechanism of fluopimomide was also evaluated, and the result showed lower EC50 values and was effective in controlling cotton seedling disease caused by Rhizoctonia solani in both greenhouse experiments and field trials. The use of LNT and fluopimomide in controlling cotton seedling damping-off disease showed a synergistic effect in field trials. These results will provide a new insight into the agricultural application of LNT as a biological fungicide in the field of biological controls.

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Activity of eugenol derivatives against Fusarium graminearum Q1 strain and screening of isoeugenol mixtures

Cited by 4 publications

References 28 publications

Transcriptomics Reveals the Effect of Thymol on the Growth and Toxin Production of Fusarium graminearum

Transcriptomics Reveals the Effect of Thymol on the Growth and Toxin Production of Fusarium graminearum

Fabrication and Characterization of Zein/PDADMAC Nanoparticles to Encapsulate Tebuconazole by Antisolvent Precipitation Method**

Use of Lentinan and Fluopimomide to Control Cotton Seedling Damping-Off Disease Caused by Rhizoctonia solani

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