Activity of East African Medicinal Plants against &lt;i&gt;Helicobacter pylori&lt;/i&gt;

Fabry, Werner; Okemo, P. O.; Ansorg, R.

doi:10.1159/000239460

Cited by 35 publications

(17 citation statements)

References 1 publication

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“…The MIC results of the three extracts corroborate earlier findings by Nariman et al (2004) who documented MIC ranges of 0.0037-2 mg/mL. Also, MIC values of 62.5-500 g/mL (0.0625-0.5 mg/mL) have been documented for East African medicinal plants (Fabry et al, 1996), and 0.32-1.28 mg/mL for Plumbago zeylanica (Wang and Huang, 2005). The MIC ranges reported in our study for the three most potent plant extracts fall within the ranges of these studies.…”

Section: Resultssupporting

confidence: 88%

In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

Ndip

Tarkang

Mbullah

et al. 2007

Journal of Ethnopharmacology

102

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Section: Resultssupporting

confidence: 88%

In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

Ndip

Tarkang

Mbullah

et al. 2007

Journal of Ethnopharmacology

102

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“…The MIC results confirm earlier findings by Nariman et al (2004) who documented MIC ranges of 0.0037 to 2 mg/mL. Also, MIC values of 0.0625 to 0.5 mg/mL have been documented for East African medicinal plants against similar bacterial pathogens (Fabry et al, 1996). A Gram positive bacterium (S. aureus) was most susceptible to H. africana compared to the Gram negative bacteria (A. hydrophila and H. pylori).…”

Section: Discussionsupporting

confidence: 89%

Bioactivity of Hydnora africana on selected bacterial pathogens: Preliminary phytochemical screening

Nethathe¹,

Ndip²

2011

Afr. J. Microbiol. Res.

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Medicinal plants contain a variety of chemical substances with important therapeutic properties that can be utilized in the treatment of human diseases. Hydonora africana is used in folklore remedies for the treatment of diarrhoea, dysentery, kidney and bladder complaints among other ailments; hence we assessed the in vitro antimicrobial activity of this plant against three bacterial species (Helicobacter pylori ATCC 43526, Helicobacter pylori PE 252C, Staphylococcus aureus NCTC 6571 and Aeromonas hydrophila ATCC 35654). The agar well diffusion method was used to determine the susceptibility of bacterial strains to crude extracts of the plant. The minimum inhibitory concentration (MIC 50 ) and minimum bactericidal concentration (MBC) of the active crude extracts were determined by the microdilution test. Ciprofloxacin (0.0125 mg/mL) was used as positive control. The presence of phytochemicals was also assessed using standard methods. Results were analyzed statistically by the one-way ANOVA test. Hydnora africana demonstrated antimicrobial activity against all the organisms with a mean zone diameter of inhibition ranging from 0 to 22 mm. The MIC 50 of the extracts ranged from 0.078 to 2.5 mg/mL and MBC ranged from 0.78 to 25 mg/mL. Phytochemical assay revealed the presence of alkaloids, tannins, flavonoids, saponins and steroids in the extracts. It is concluded that H. africana may contain compounds with therapeutic activity.

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“…For example, Terminalia spinosa, an East African plant, inhibited the growth of HP, with a MIC range of 62.5 -500 µg/ml (Fabry et al, 1996). Extracts of Thymus vulgaris and Cinnamonum zeylanicum also inhibited the growth of the bacterium, (Tabak et al, 1996) and extracts of garlic (Allium sativum) were effective, with an MIC range of 20-40.0 µg/ml (Sivam et al, 1997;Jonkers, 1999).…”

Section: Discussionmentioning

confidence: 99%

In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis

Mahady

Pendland

Stoia

et al. 2003

Phytotherapy Research

114

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Methanol extracts of the rhizomes of Sanguinaria canadensis, and the roots and rhizomes of Hydrastis canadensis, two plants used traditionally for the treatment of gastrointestinal ailments, were screened for in vitro antibacterial activity against 15 strains of Helicobacter pylori. The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5-50.0 microg/ml. Three isoquinoline alkaloids were identified in the active fraction. Sanguinarine and chelerythrine, two benzophenanthridine alkaloids, inhibited the growth of the bacterium, with an MIC50 of 50.0 and 100.0 microg/ml, respectively. Protopine, a protopine alkaloid, also inhibited the growth of the bacterium, with a MIC50 of 100 microg/ml. The crude methanol extract of H. canadensis rhizomes was very active, with an MIC50 of 12.5 microg/ml. Two isoquinoline alkaloids, berberine and beta-hydrastine, were identified as the active constituents, and having an MIC50 of 12.5 and 100.0 microg/ml, respectively.

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Activity of East African Medicinal Plants against <i>Helicobacter pylori</i>

Cited by 35 publications

References 1 publication

In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

Bioactivity of Hydnora africana on selected bacterial pathogens: Preliminary phytochemical screening

In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis

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