In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

Ndip, Roland N.; Tarkang, Alertia E. Malange; Mbullah, Susan M.; Luma, Henry Namme; Malongue, Agnès; Ndip, Lucy; Nyongbela, Kennedy D.; Wirmum, C.; Efange, Simon M. N.

doi:10.1016/j.jep.2007.08.037

Cited by 102 publications

(76 citation statements)

References 24 publications

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“…Therefore, methanol extract of E. hirta possessed a broad spectrum of antimicrobial activity against studied bacterial strains. However, its inhibitory effect on H. pylori effects was weak (Ndip et al, 2007). Interestingly, E. hirta was not found to be very effective for anti-fungal activity by others (Abu-Sayeed et al, 2005;Singh et al, 2011).…”

Section: Effects Of E Hirta On Anti-infectionmentioning

confidence: 96%

Potential Applications of Euphorbia hirta in Pharmacology

Shih¹,

Cherng²

2012

Drug Discovery Research in Pharmacognosy

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Section: Effects Of E Hirta On Anti-infectionmentioning

confidence: 96%

Potential Applications of Euphorbia hirta in Pharmacology

Shih¹,

Cherng²

2012

Drug Discovery Research in Pharmacognosy

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“…The method described by Ndip et al (2008) to prepare extracts was employed with modifications. The plant was harvested, air dried for 2 weeks and ground to fine powder using a blender (ATO MSE mix, 702732, England).…”

Section: Preparation Of Plant Extractsmentioning

confidence: 99%

“…To determine the MBC, 0.2 mL of the contents of the MIC was serially diluted tenfold in 0.9% physiological saline (Ndip et al, 2007). A loop full was taken from each tube and inoculated onto BHI agar plates.…”

Section: Determination Of Minimum Bactericidal Concentration (Mbc)mentioning

confidence: 99%

“…Helicobacter pylorus is a Gram-negative, microaerophilic bacterium that causes duodenal ulceration, chronic gastritis and gastric cancer. (Ndip et al, 2008). An increasing number of infected individuals are found to harbour antibiotic-resistant strains (Ndip et al, 2008;Tanih et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…(Ndip et al, 2008). An increasing number of infected individuals are found to harbour antibiotic-resistant strains (Ndip et al, 2008;Tanih et al, 2010). The emerging resistance to antibiotics, especially metronidazole and amoxicillin limits their use in the treatment of infections (Smith et al, 2001;Tanih et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Bioactivity of Hydnora africana on selected bacterial pathogens: Preliminary phytochemical screening

Nethathe¹,

Ndip²

2011

Afr. J. Microbiol. Res.

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Medicinal plants contain a variety of chemical substances with important therapeutic properties that can be utilized in the treatment of human diseases. Hydonora africana is used in folklore remedies for the treatment of diarrhoea, dysentery, kidney and bladder complaints among other ailments; hence we assessed the in vitro antimicrobial activity of this plant against three bacterial species (Helicobacter pylori ATCC 43526, Helicobacter pylori PE 252C, Staphylococcus aureus NCTC 6571 and Aeromonas hydrophila ATCC 35654). The agar well diffusion method was used to determine the susceptibility of bacterial strains to crude extracts of the plant. The minimum inhibitory concentration (MIC 50 ) and minimum bactericidal concentration (MBC) of the active crude extracts were determined by the microdilution test. Ciprofloxacin (0.0125 mg/mL) was used as positive control. The presence of phytochemicals was also assessed using standard methods. Results were analyzed statistically by the one-way ANOVA test. Hydnora africana demonstrated antimicrobial activity against all the organisms with a mean zone diameter of inhibition ranging from 0 to 22 mm. The MIC 50 of the extracts ranged from 0.078 to 2.5 mg/mL and MBC ranged from 0.78 to 25 mg/mL. Phytochemical assay revealed the presence of alkaloids, tannins, flavonoids, saponins and steroids in the extracts. It is concluded that H. africana may contain compounds with therapeutic activity.

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Herbal medicine as an auspicious therapeutic approach for the eradication ofHelicobacter pyloriinfection: A concise review

Ghasemian

Fattahi

Mostafavi

et al. 2019

Journal Cellular Physiology

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Helicobacter pylori (H. pylori) causes gastric mucosa inflammation and gastric cancer mostly via several virulence factors. Induction of proinflammatory pathways plays a crucial role in chronic inflammation, gastric carcinoma, and H. pylori pathogenesis. Herbal medicines (HMs) are nontoxic, inexpensive, and mostly anti‐inflammatory reminding meticulous emphasis on the elimination of H. pylori and gastric cancer. Several HM has exerted paramount anti‐H. pylori traits. In addition, they exert anti‐inflammatory effects through several cellular circuits such as inhibition of 5′‐adenosine monophosphate‐activated protein kinase, nuclear factor‐κB, and activator protein‐1 pathway activation leading to the inhibition of proinflammatory cytokines (interleukin 1α [IL‐1α], IL‐1β, IL‐6, IL‐8, IL‐12, interferon γ, and tumor necrosis factor‐α) expression. Furthermore, they inhibit nitrous oxide release and COX‐2 and iNOS activity. The apoptosis induction in Th1 and Th17‐polarized lymphocytes and M2‐macrophagic polarization and STAT6 activation has also been exhibited. Thus, their exact consumable amount has not been revealed, and clinical trials are needed to achieve optimal concentration and their pharmacokinetics. In the aspect of bioavailability, solubility, absorption, and metabolism of herbal compounds, nanocarriers such as poly lactideco‐glycolide‐based loading and related formulations are helpful. Noticeably, combined therapies accompanied by probiotics can also be examined for better clearance of gastric mucosa. In addition, downregulation of inflammatory microRNAs (miRNAs) by HMs and upregulation of those anti‐inflammatory miRNAs is proposed to protect the gastric mucosa. Thus there is anticipation that in near future HM‐based formulations and proper delivery systems are possibly applicable against gastric cancer or other ailments because of H. pylori.

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In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

Cited by 102 publications

References 24 publications

Potential Applications of Euphorbia hirta in Pharmacology

Potential Applications of Euphorbia hirta in Pharmacology

Bioactivity of Hydnora africana on selected bacterial pathogens: Preliminary phytochemical screening

Herbal medicine as an auspicious therapeutic approach for the eradication ofHelicobacter pyloriinfection: A concise review

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