Activity of Compounds Isolated From Chilean Lichens Against Experimental Cutaneous Leishmaniasis

Fournet, Alain; Ferreira, Marı́a Elena; Arias, Antonieta Rojas de; Ortiz, Susana Torres de; Inchausti, Alba; Yalaff, Gloria; Quilhot, Wanda; Fernández, Ernesto; Hidalgo, María Eliana

doi:10.1016/s0742-8413(96)00127-2

Cited by 45 publications

(46 citation statements)

References 10 publications

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“…The leishmanicidal properties of usnic acid has also demonstrated some success by in vitro and in vivo experiments (Fournet et al 1997), with a reduction in the weight of lesions and in parasite loads. However, Copaiba oil and usnic acid seem to have no effect in formulations without pentamidine in lesions caused by L. amazonensis, whereas group ACU (Andiroba, Copaiba and usnic acid) did not show a reduction in the size of lesions or parasite loads.…”

Section: Discussionmentioning

confidence: 97%

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

et al. 2017

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Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day -1. After treatment tissue samples of lesions were evaluated by histology, transmission electron microscopy and biopsy cultivation. Compared with untreated group, topical treatment with hydrating emulsion with 10% PI and usnic acid (ACE5AU) showed significantly decrease in volume lesion (P= 0.028) on 20 th day after the end of the treatment with reduction of 27.37%. Topical treatment with anhydrous emulsion with 10% PI and usnic acid (ACPU) reduces parasite burden in Golden hamsters. This study demonstrated the potential of topical treatment to reduce the number of parasites that could be combined with others drugs and to have a faster and more effective treatment of cutaneous leishmaniasis.

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Section: Discussionmentioning

confidence: 97%

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

et al. 2017

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“…Cladonia, Ramalina, Usnea and others. The biological activities of usnic acid such as antiviral (Scirpa et al 1999), antifungal (Lauterwein et al 1995, Lawrey 1995, Cocchietto et al 2002, antiprotozoal (Fournet et al 1997), antiproliferative, antiherbivoral (Huneck 1999), analgesic (Vijayakumar et al 2000), hepatotoxic (Pramyothin et al 2004) have been reviewed by Ingolfsdottir (2002). Rankovic et al (2007) determined that usnic asid has the strongest antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of some terricolous lichens [Cladonia rangiformis Hoffm., Peltigera neckerii Hepp ex Müll. Arg., Peltigera rufescens (Weiss) Humb.] on soil bacteria in natural conditions

Akpinar¹,

Öztürk²,

Si̇ni̇rtas³

2009

PLANT SOIL ENVIRON

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This paper is aimed to investigate the effects of some terricolous lichens on soil bacteria's growth in natural conditions. It is focused on species of bacteria and also on numbers of colony of soil specimens that were taken from substrates of three different terricolous lichen species. Peltigera rufescens (Weiss) Humb., which has not secondary metabolites, did not show an inhibition effect on soil bacteria. However, Peltigera neckerii Hepp ex Müll. Arg., which has secondary metabolites, has a negative effect on soil bacteria's growth. Besides, it was observed that Cladonia rangiformis Hoffm., which has many kinds of secondary metabolites, has the highest inhibition effect among the studied species. For this reason, we think that in the next researches, it is convenient to investigate elaborately by soil analysis the effect of lichen's secondary metabolites that have an effect on soil mineralization, on soil bacteria's growth.

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“…Wu et al [27] stated that (K) usnic acid exhibited a strong effect against Trichomonas vaginalis in vitro. Intralesional administration of (+) usnic acid in mice infected with Leishmania promastigotes produced a significant reduction of cutaneous lesions and parasite loads [40] . Luz et al [40] also determined the antileishmanial activity of usnic acid on L. infantum chagasi promastigotes and suggested that usnic acid as a possible phytotherapic agent in the treatment of visceral leishmaniasis.…”

Section: Feed Conversion Ratio (Fcr Feed: Bw Gain)mentioning

confidence: 95%

Usnik Asitin Broylerlerdeki Anticoccidial Etkinliği

Güven¹,

Avcıoğlu²,

Aslan³

et al. 2016

Kafkas Univ Vet Fak Derg

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This experiment was conducted to investigate if usnic acid, a lichen metabolite, exerts therapeutic action against coccidiosis. A total of 160 one-day-old male Ross 308 broiler chicks were divided into 5 experimental groups (A-E), each replicated in 4 pens of 8 chicks. At 16 days of age Groups B-E were infected orally with a mixture of purified oocysts including 30 x 10 4 sporulated oocysts from field isolates of E. acervulina, E. brunetti, E. maxima, E. mitis, E. praecox and E. tenella, whereas Group A was remained uninfected. Seven days after the coccidiosis induction, infected birds were divided into 4 groups to receive orally with 20 mg usnic acid (Group C), 100 mg usnic acid (Group D) and 7 mg toltrazuril (Group E) per kg body weight. The birds in Group B were untreated and served as infected control. The experiment was terminated at 29 days of age. As a result of the study it was evaluated that infected birds had lower feed intake and body weight and worse feed conversion, higher intestinal lesion score, longer small intestine and cecum, and higher fecal oocyst count than healthy birds. The anticoccidial effect of usnic acid at 100 mg/kg application dose was comparable to toltrazuril as reflected by alleviations in performance and pathology findings. In conclusion, it is demonstrated that usnic acid possesses some anticoccidial effects, but not nearly as good as toltrazuril. Keywords: Lichen, Usnic acid, Toltrazuril, Broiler, Coccidiosis Usnik Asitin Broylerlerdeki Anticoccidial Etkinliği ÖzetBu çalışmada, bir liken metaboliti olan usnik asitin coccidiosise karşı terapötik etkinliğinin araştırılması amaçlanmıştır. Toplam 160 adet, 1 günlük yaştaki erkek Ross 308 civciv, her bir grup 4 tekerrürlü olacak şekilde 5 deneysel gruba (A-E) ayrılmıştır. Hayvanlar 16 günlük yaşa geldiğinde Grup B-E'dekiler E. acervulina, E. brunetti, E. maxima, E. mitis, E. praecox ve E. tenella'nın saha izolatlarından elde edilmiş inokulumdan 30 x 10 4 sporlanmış oocyst ile enfekte edilmiştir. Grup A'da yer alanlar civcivler ise enfekte edilmeden kontrol olarak bırakılmıştır. Hastalık oluşturulduktan 7 gün sonra, enfekte hayvanlara ağız yolu ile 20 mg/kg usnik asit (Grup C), 100 mg/kg usnik asit (Grup D) ve 7 mg/kg toltrazuril (Grup E) uygulanmış; B grubundaki enfekte hayvanlara tedavi uygulanmadan enfekte kontrol olarak bırakılmıştır. Broylerler 29 günlük olduğunda çalışma sona erdirilmiştir. Enfekte hayvanların sağlıklı hayvanlara kıyasla daha düşük yem tüketimi, vücut ağırlığı ve yemden yararlanma oranına; daha yüksek lezyon skoruna, daha uzun bağırsak uzunluğuna ve daha yüksek oocyst sayısına sahip olduğu tespit edilmiştir. Performans ve patolojik bulgulardaki değişimler göz önünde bulundurulduğunda 100 mg/kg dozda uygulanan usnik asitin toltrazuril ile karşılaştırılabilecek derecede anticoccidal etkinliğe sahip olduğu belirlenmiştir. Sonuç olarak; usnik asitin bazı anticoccidial etkinliklere sahip olduğu ancak bu etkilerin toltrazuril kadar güçlü olmadığı kanısına varılmıştır.

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Activity of Compounds Isolated From Chilean Lichens Against Experimental Cutaneous Leishmaniasis

Cited by 45 publications

References 10 publications

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

Effects of some terricolous lichens [Cladonia rangiformis Hoffm., Peltigera neckerii Hepp ex Müll. Arg., Peltigera rufescens (Weiss) Humb.] on soil bacteria in natural conditions

Usnik Asitin Broylerlerdeki Anticoccidial Etkinliği

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