Activity of Aqueous Extracts of Lion's Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) on the Neural Cell Line NG108-15

A comprehensive review of the therapeutic effects of Hericium erinaceus in neurodegenerative disease

“…Also, ethanol extract of H. erinaceus promoted the neurite outgrowth of PC12 cells, enhanced NGF mRNA expression, and the secretion of NGF from 1321N1 human astrocytoma cells (Wong et al, 2007). In a astrocytoma cells (Mori et al, 2008), it was determined that while a methanol extract of H. erinaceus stimulated an increase in NGF as evidenced in the assay of RNA associated with NGF production.…”

Neurite outgrowth stimulatory effects of myco­synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells

“…39,40 A previous study showed that the aqueous extracts prepared from the fruiting bodies and mycelium of H. erinaceus stimulate neurite outgrowth from cultured cells of the neural hybrid clone NG108-15. 6 The aqueous extract of H. erinaceus fresh basidiocarps was able to promote neurite outgrowth and nerve regeneration, and accelerate motor functional recovery of rodents in vivo after crash injury. 7 The uniqueness of PC-12 cell line is that it responds to NGF, and NGF mimics extract of H. erinaceus and AuNPs …”

“…Previous studies have reported antimicrobial effects, antitumor activities, antioxidant properties, stimulation of neurite outgrowth, and nerve regeneration. [4][5][6][7][8] Neurobiologists and neuroscientists are exploring the field of nerve regeneration, which has become one of the biggest and most funded areas in medical research. Many neurodegenerative diseases such as Alzheimer's disease, dementia, Parkinson's disease, and age-related macular degeneration occur in the central nervous system (CNS).…”

Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration

“…(8) Extract of fruitbodies exerted neurotrophic action and improved myelination process in mature myelinating fibers of nerve cells in vitro (9) and also promoted normal development of cultivated cerebellar cells and demonstrated a regulatory effect on the process of myelin genesis in vitro. (10) Our studies have shown that aqueous extract of H. erinaceus could stimulate neurite outgrowth of the cultured cells of the neural hybrid clone NG108-15 (11) and enhance functional recovery following injury to rodent peroneal nerve. (12) These findings indicate that H. erinaceus may have a potential in stimulation of neurons to regrow in the treatment of senility, Alzheimer's disease, repairing neurological trauma from strokes, improve muscle or motor response pathways and cognitive function.…”