Activity of antibacterial, antiviral, anti-inflammatory in compounds andrographolide salt

Li, Wen; Xia, Nan; Chen, Xianghong; Li, Yingxiu; Yi, Hong; Liu, Yajie; Wang, ZiZhen

doi:10.1016/j.ejphar.2014.06.053

Cited by 54 publications

(29 citation statements)

References 22 publications

(20 reference statements)

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“…AGP, the major active ingredient of the herbal medicine A. paniculata, has been shown to exert various biological activities, including antitumor (Yang et al, 2014), anti-inflammatory (Ku and Lin, 2013), antiviral (Wen et al, 2014), and hepatoprotective effects (Lee et al, 2014). In this study, we showed that AGP significantly inhibited RANKL-induced osteoclast differentiation from RAW 264.7 murine macrophage cells and decreased the number of osteoclasts and the mRNA expression of TRAP.…”

Section: Discussionmentioning

confidence: 49%

“…Several studies have demonstrated that AGP exhibits various biological activities, including antitumor (Yang et al, 2014), anti-inflammatory (Ku and Lin, 2013), antiviral (Wen et al, 2014), and hepatoprotective effects (Lee et al, 2014). It has been demonstrated that AGP can attenuate inflammation by inhibiting NF-kappaB activation through covalent modification of the reduced cys62 residue of p50 (Xia et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway

Ren

Yuan

2015

Genet. Mol. Res.

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ABSTRACT. This study aims to investigate the effects of andrographolide (AGP) on osteoclast formation in RAW 264.7 murine macrophage cells. The effects of AGP on cell viability were determined in RAW 264.7 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The effects of AGP on osteoclast formation were tested by osteoclast staining with tartrate-resistant acid phosphatase (TRAP). The effects of AGP on receptor activator of nuclear factor-kappaB (NFkappaB) ligand (RANKL)-induced, NF-kappaB-dependent transcription in RAW 264.7 cells were assessed using luciferase reporter assays. The results demonstrated that the viability of osteoclast precursor RAW 264.7 cells was not affected by AGP treatment at a concentration of 0.4 to 10 μM. Additionally, the number of TRAP-positive osteoclasts was significantly reduced by the same concentrations of AGP treatment. AGP also inhibited RANKL-induced NF-kappaB activation in a dose-dependent 15955-15961 (2015) fashion as evidenced by luciferase reporter assays. In summary, this study demonstrates that AGP inhibits osteoclastogenesis in RAW 264.7 murine macrophage cells through downregulation of the NF-kappaB signaling pathway.

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway

Ren

Yuan

2015

Genet. Mol. Res.

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“…It has also been proved to have many pharmacological actions, such as anti-inflammatory, anti-infection, anticancer, antihyperglycemia, anti-angiogenesis, immunostimulation, hepatoprotection, antifertility and anti-HIV effects (Du et al, 2012;Tu et al, 2014;Wen et al, 2014). The potential use of ADG has attracted wide attention in recent years.…”

Section: Introductionmentioning

confidence: 98%

Dry state microcrystals stabilized by an HPMC film to improve the bioavailability of andrographolide

Liu

et al. 2015

International Journal of Pharmaceutics

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“…Andrographolide treatment decreases hepatic neutrophil/macrophage infiltration, down regulates local inflammation, and reduces liver damage in thioacetamide-induced mouse hepatic fibrosis 6 . The anti-inflammatory effect of andrographolide is induced by inhibiting the NF-κB signaling pathway 7–9 . Mass spectrometry result and molecular docking analysis revealed that andrographolide binds to the NF-κB p50 subunit at Cys62 position 10 .…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway

Nie

Chen

Wang

et al. 2017

Sci Rep

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Andrographolide derivatives or analogs exhibit potent anti-inflammatory effects in several disease models through NF-κB activity. In this study, we synthesized different andrographolide derivatives and investigated their effects on the toll-like receptor (TLR)-induced production of pro-inflammatory cytokines. Among these compounds, 3b, 5a, and 5b inhibited both TNF-α/NF-κB and TLR4/NF-κB signaling pathways. Treatment with compounds 3b, 5a, and 5b and their structural analogs, 3a and 6b, suppressed the expression of pro-inflammatory cytokines upon the activation of TLR3 and TLR4 ligands. Compounds 3b and 5a, but not 3a, 5b, or 6b, inhibited the nuclear translocation of the NF-κB p65 subunit. Treatment with compounds 3b, 5a, 3a, 5b, and 6b attenuated the phosphorylation of p65 and IκBα. Compounds 6b suppressed the expression of the NF-κB p65 subunit. However, these compounds, except for 5b, did not affect the TLR9-induced NF-κB-independent production of the pro-inflammatory cytokines, TNF-α, and IFN-β. Compound 3b potentially protected mice from LPS-induced acute pulmonary inflammation through the inhibition of p65 phosphorylation and the decrease of serum pro-inflammatory cytokines and chemokine. Our study revealed a functional structure–activity relationship between andrographolide derivatives and innate immunity. We identified compound 3b as a potent immune suppressive agent with the potential to protect acute pulmonary infection.

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Activity of antibacterial, antiviral, anti-inflammatory in compounds andrographolide salt

Cited by 54 publications

References 22 publications

Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway

Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway

Dry state microcrystals stabilized by an HPMC film to improve the bioavailability of andrographolide

Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway

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