Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin

Freeman, Arthur; Bunney, Benjamin S.

doi:10.1016/0006-8993(87)90988-7

Cited by 155 publications

(103 citation statements)

References 28 publications

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“…The mean firing rate and bursting parameters of VTA dopamine cells recorded in head restrained rat during quiet waking are consistent with those reported previously in freely moving rats during this state (Freeman and Bunney, 1987;Hyland et al, 2002;Kiyatkin and Rebec, 1998;Miller et al, 1983). These values contrast with those reported in a recent study which showed that acute stressful restraint increased dopamine neuron firing rate and bursting activity (Anstrom and Woodward, 2005).…”

Section: Discussionsupporting

confidence: 90%

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Dahan

Astier

Vautrelle

et al. 2006

Neuropsychopharmacol

255

173

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Dopamine is involved in motivation, memory, and reward processing. However, it is not clear whether the activity of dopamine neurons is related or not to vigilance states. Using unit recordings in unanesthetized head restrained rats we measured the firing pattern of dopamine neurons of the ventral tegmental area across the sleep-wake cycle. We found these cells were activated during paradoxical sleep (PS) via a clear switch to a prominent bursting pattern, which is known to induce large synaptic dopamine release. This activation during PS was similar to the activity measured during the consumption of palatable food. Thus, as it does during waking in response to novelty and reward, dopamine could modulate brain plasticity and thus participate in memory consolidation during PS. By challenging the traditional view that dopamine is the only aminergic group not involved in sleep physiology, this study provides an alternative perspective that may be crucial for understanding the physiological function of PS and dream mentation.

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Section: Discussionsupporting

confidence: 90%

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Dahan

Astier

Vautrelle

et al. 2006

Neuropsychopharmacol

255

173

View full text Add to dashboard Cite

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“…However, in terms of absolute magnitude, the increase was relatively week (~12 imp/s). This response pattern well agrees with preferential excitations of presumed DA neurons induced by arousing somato-sensory stimuli in awake animals, as shown both in the SNc (Freeman et al, 1985;Freeman and Bunney, 1987;Steinfels et al, 1983;Strecker et al, 1985;Schultz, 1986;Trulson, 1985) and VTA (Guarraci and Kapp, 1999;Freeman and Bunney, 1987;Kiyatkin, 1988;Horvitz et al, 1997;Schultz, 1986). These data are also consistent with large body of neurochemical data (DA metabolism, [DA] evaluated by microdialysis or electrochemistry) suggesting increased DA release, especially in cortical projections, associated with arousing and aversive stimulation (Abercrombie et al, 1989;Deutch et al, 1985;Fadda et al, 1978;Feenstra et al, 2000Feenstra et al, , 2001Kiyatkin, 1995;Le Moal and Simon, 1991;Thierry et al, 1976).…”

Section: Sensory Responses Of Ls and Ss Vta Neuronssupporting

confidence: 82%

Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons

Brown

Kiyatkin

2008

Brain Research

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Intravenous (iv) cocaine mimics salient somato-sensory stimuli in their ability to induce rapid physiological effects, which appear to involve its action on peripherally located neural elements and fast neural transmission via somato-sensory pathways. To further clarify this mechanism, single-unit recording with fine glass electrodes was used in awake rats to examine responses of ventral tegmental area (VTA) neurons, both presumed dopamine (DA) and non-DA, to iv cocaine and tail-press, a typical somato-sensory stimulus. To exclude the contribution of DA mechanisms to the observed neuronal responses to sensory stimuli and cocaine, recordings were conducted during full DA receptor blockade (SCH23390+eticloptide).Iv cocaine (0.25 mg/kg delivered over 10 s) induces significant excitations of ~63% of long-spike (presumed DA) and ~70% of short-spike (presumed non-DA) VTA neurons. In both subgroups, neuronal excitations occurred with short latencies (4-8 s), peaked at 10-20 s (30-40% increase over baseline) and disappeared at 30-40 s after the injection onset. Most long-(67%) and short-spike (89%) VTA neurons also showed phasic responses to tail-press (5-s). All responsive long-spike cells were excited by tail-press; excitations were very rapid (peak at 1 s) and strong (100% rate increase over baseline) but brief (2-3 s). In contrast, both excitations (60%) and inhibitions (29%) were seen in short-spike cells. These responses were also rapid and transient, but excitations of short-spike units were more prolonged and sustained (10-15 s) than in long-spike cells.These data suggest that in awake animals iv cocaine, like somato-sensory stimuli, rapidly and transiently excites VTA neurons of different subtypes. Therefore, along with direct action on specific brain substrates, central effects of cocaine may occur via indirect mechanism, involving peripheral neural elements, visceral sensory nerves and rapid neural transmission. Via this mechanism, cocaine, like somato-sensory stimuli, can rapidly activate DA neurons and induce phasic DA release, creating the conditions for DA accumulation by a later occurring and prolonged direct inhibiting action on DA uptake. By providing a rapid neural signal and triggering transient neural activation, such a peripherally driven action might play a crucial role in the sensory effects of COC, thus contributing to learning and development of drug-taking behavior.

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“…Electrophysiological studies have shown that most of the nigrostriatal neurons have a slow firing rate (from 0 to 6 spikes/sec). In addition, some neurons fire with a burst activity and the maximal spike frequency within the bursts reaches 20 Hz (Grace and Bunney 1984;Freeman and Bunney 1987). In the present exploratory study we choose to apply high frequency stimulations because they were shown to be the most effective to induce striatal DA overflow in vivo and to enhance DA extracellular concentration up to 10 M (Gonon and Buda 1985).…”

Section: Discussionmentioning

confidence: 99%

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Ginovart

Hassoun

Cavorsin

et al. 2002

Neuropsychopharmacology

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Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin

Cited by 155 publications

References 28 publications

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

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