Activity-induced manganese-dependent functional MRI of the rat visual cortex following intranasal manganese chloride administration

Fa, Zhiqiang; Zhang, Peng; Huang, Fanheng; Zhang, Run; Xu, Ran; Wen, Zhibo; Jiang, Xiao-dan

doi:10.1016/j.neulet.2010.06.063

Cited by 20 publications

(14 citation statements)

References 23 publications

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“…Solitary MMSC were detected in the brain parenchyma. These fi ndings agree with the results of MRI of rats with OBE that demonstrated impairment of the blood-brain barrier in these animals [8]. This suggests that MMSC concentrated in areas of neural stem cell accumulation can stimulate their proliferation thus inducing neurogenesis.…”

Section: Resultssupporting

confidence: 90%

Localization and Differentiation Pattern of Transplanted Human Multipotent Mesenchymal Stromal Cells in the Brain of Bulbectomized Mice

et al. 2014

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Replacement cell therapy with transplantation of stem cells is a promising approach for the therapy of various neurodegenerative diseases, e.g. Alzheimer's disease. However, the behavior of transplanted cells in the damaged tissue should be thoroughly studied before introduction of this method into clinical practice. We studied the pathways of migration of human multipotent mesenchymal stromal cells after their systemic transplantation into the brain of bulbectomized mice characterized by the development of Alzheimer-type neurodegenerative process. Immunohistochemical analysis with antibodies to human nuclear antigen (HNA) and immunofluorescent analysis of the results of transplantation of multipotent mesenchymal stromal cells carrying green fluorescent protein (GFP) gene showed that these cells can cross the blood-brain barrier and penetrate into some structures of recipient brain. Analysis of differentiation of transplanted human cells using antibodies to neurospecific enolase (NSE) or astroglial marker (GFAP) with parallel staining for human nuclear antigen revealed no neural differentiation of transplanted cells in the brains of bulbectomized animals. However, some of these cells differentiated into astrocytes, which brought us to an assumption on important role of astroglial abnormalities in the pathogenesis of Alzheimer's disease.

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Section: Resultssupporting

confidence: 90%

Localization and Differentiation Pattern of Transplanted Human Multipotent Mesenchymal Stromal Cells in the Brain of Bulbectomized Mice

et al. 2014

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“…To this end, brain manganese levels were measured using signal intensities from T 1 -weighted images. Normalization to adjacent tissue is a common part of this approach, either to a negative-control brain region [56], [57] or to nearby muscle [18], [27], [55], [58]. The tissue used for normalization must be carefully selected, as underlying group differences there may obscure or over-emphasize group differences in regions of experimental interest.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Key Tinnitus-Related Brain Regions Documented by a Unique Combination of Manganese-Enhanced MRI and Acoustic Startle Reflex Testing

et al. 2010

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Animal models continue to improve our understanding of tinnitus pathogenesis and aid in development of new treatments. However, there are no diagnostic biomarkers for tinnitus-related pathophysiology for use in awake, freely moving animals. To address this disparity, two complementary methods were combined to examine reliable tinnitus models (rats repeatedly administered salicylate or exposed to a single noise event): inhibition of acoustic startle and manganese-enhanced MRI. Salicylate-induced tinnitus resulted in wide spread supernormal manganese uptake compared to noise-induced tinnitus. Neither model demonstrated significant differences in the auditory cortex. Only in the dorsal cortex of the inferior colliculus (DCIC) did both models exhibit supernormal uptake. Therefore, abnormal membrane depolarization in the DCIC appears to be important in tinnitus-mediated activity. Our results provide the foundation for future studies correlating the severity and longevity of tinnitus with hearing loss and neuronal activity in specific brain regions and tools for evaluating treatment efficacy across paradigms.

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“…Mn 2+ has paramagnetic ion characteristics and magnetic resonance systems can therefore be used to detect neuronal changes after different types of stimulation [17,18]. For example, Mn 2+ -enhanced MRI (MEMRI) has been used to identify brains areas activated by noise exposure in mice, to differentiate between normal and ischemic heart regions in dogs [7], to image the rat visual cortex [6], and to detect alterations and study glaucoma in mouse models [2]. MEMRI has the potential to reveal structural alterations and neural activity patterns and provide functional information.…”

Section: Introductionmentioning

confidence: 99%

Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation

Cha

Lee

et al. 2016

Neuroscience Letters

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Activity-induced manganese-dependent functional MRI of the rat visual cortex following intranasal manganese chloride administration

Cited by 20 publications

References 23 publications

Localization and Differentiation Pattern of Transplanted Human Multipotent Mesenchymal Stromal Cells in the Brain of Bulbectomized Mice

Localization and Differentiation Pattern of Transplanted Human Multipotent Mesenchymal Stromal Cells in the Brain of Bulbectomized Mice

Evidence of Key Tinnitus-Related Brain Regions Documented by a Unique Combination of Manganese-Enhanced MRI and Acoustic Startle Reflex Testing

Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation

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