Activity-based cost analysis of opioid-related nausea and vomiting among inpatients

Eberhart, Leopold; Koch, T.; Kranke, Peter; Rüsch, Dirk; Torossian, Alexander; Nardi-Hiebl, Stefan

doi:10.5055/jom.2014.0238

Cited by 13 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our model, we estimate that the cost of treating an episode of nausea would range between €5 and €12 in the EU5 and between €9 and €20 for an episode of vomiting. These costs are lower than those estimated by Eberhart et al in Germany [ 58 ]. The authors estimated the cost of an episode of nausea and/or vomiting that occurred during or after administration of opioid drug, based on the data from 462 inpatients in 16 German hospitals.…”

Section: Discussioncontrasting

confidence: 53%

“…The authors estimated the cost of an episode of nausea and/or vomiting that occurred during or after administration of opioid drug, based on the data from 462 inpatients in 16 German hospitals. The costs for an episode of nausea and/or vomiting was estimated as €31±22 when including both the workforce time (€18±14) and materials (€14±13) [ 58 ]. The higher costs in Eberhart et al, compared with our estimates, are partly due to inclusion in Eberhart et al of the costs of material, such as IV lines or gastric tubes, that had to be replaced because of nausea and/or vomiting.…”

Section: Discussionmentioning

confidence: 99%

“…No additional costs were included for the saline needed for preparing the metoclopramide solution, as it is assumed that saline is taken from the 100 mL bag used for preparing the morphine solution. Nursing time associated with the treatment of IV-morphine induced nausea and vomiting was derived from Eberhart et al [ 58 ], a German study (149 subjects) that measured the time spent by nurses to treat episodes of nausea and/or vomiting in a general ward. Time for management of nausea and vomiting was 16.9 and 33.4 minutes, respectively.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Administration of intravenous morphine for acute pain in the emergency department inflicts an economic burden in Europe

Casamayor¹,

DiDonato²,

Hennebert³

et al. 2018

DIC

View full text Add to dashboard Cite

BackgroundAcute pain is among the leading causes of referral to the emergency department (ED) in industrialized countries. Its management mainly depends on intensity. Moderate-to-severe pain is treated with intravenous (IV) administered opioids, of which morphine is the most commonly used in the ED. We have estimated the burden of IV administration of morphine in the five key European countries (EU5) using a micro-costing approach.ScopeA structured literature review was conducted to identify clinical guidelines for acute pain management in EU5 and clinical studies conducted in the ED setting. The data identified in this literature review constituted the source for all model input parameters, which were clustered as analgesic (morphine), material used for IV morphine administration, nurse workforce time and management of morphine-related adverse events and IV-related complications.FindingsThe cost per patient of IV morphine administration in the ED ranges between €18.31 in Spain and €28.38 in Germany. If costs associated with the management of morphine-related adverse events and IV-related complications are also considered, the total costs amount to €121.13–€132.43. The main driver of those total costs is the management of IV-related complications (phlebitis, extravasation and IV prescription errors; 73% of all costs) followed by workforce time (14%).ConclusionsIV morphine provides effective pain relief in the ED, but the costs associated with the IV administration inflict an economic burden on the respective national health services in EU5. An equally rapid-onset and efficacious analgesic that does not require IV administration could reduce this burden.

show abstract

Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Administration of intravenous morphine for acute pain in the emergency department inflicts an economic burden in Europe

Casamayor¹,

DiDonato²,

Hennebert³

et al. 2018

DIC

View full text Add to dashboard Cite

show abstract

“…The need to minimize the troublesome side effects of opioids to optimize pain management and curtail-associated health care costs suggests a potentially important role for antiemetic co-prescribing. Prophylactic use of antiemetics may improve patient outcomes, including quality of life, and reduce the burden on caregivers, providers, and the health care system [16, 31, 32, 42]. …”

Section: Discussionmentioning

confidence: 99%

“…While there are ample data regarding the economic consequences of nausea and vomiting (NV) in the hospital setting [23, 32–35], corresponding data in the outpatient setting are limited. A previous study that examined the costs of gastrointestinal events in outpatients treated with immediate-release (IR) opioids for noncancer pain found that NV was associated with increased all-cause health care utilization and costs over a 3-month follow-up period [31].…”

Section: Introductionmentioning

confidence: 99%

Health Care Utilization and Costs Associated with Nausea and Vomiting in Patients Receiving Oral Immediate-Release Opioids for Outpatient Acute Pain Management

Marrett

Kwong

Frech³

et al. 2016

Pain Ther

View full text Add to dashboard Cite

IntroductionNausea and vomiting (NV) are common side effects of opioid use and limiting factors in pain management. This study sought to quantify the frequency of antiemetic prescribing and the impact of NV on health care resource utilization and costs in outpatients prescribed opioids for acute pain. The perspective was that of a commercial health plan.MethodsMedical and pharmacy claims from IMS PharMetrics Plus were used to identify patients initiating opioid therapy with a prescription for an oxycodone-, hydrocodone- or codeine-containing immediate-release product for acute use (≤15-day supply) between October 1, 2013 and September 30, 2014. Patients with a medical claim for NV (International Classification of Diseases, Ninth Revision, Clinical Modification codes 787.0x), with or without an antiemetic prescription fill, were compared with patients with no NV claim or antiemetic prescription fill to assess differences in all-cause health care utilization and costs over 1 month. Propensity score matching (PSM) was used to adjust for between-group differences in baseline patient characteristics.ResultsThe co-prescribing of opioids with antiemetic agents was 10.2%. After PSM (n = 45,790 per group), patients with NV claims had significantly more hospitalizations (11.5% vs 4.2%), emergency department visits (65.0% vs 12.1%), and physician office visits (85.2% vs 64.5%) compared with patients with no NV claims (all P < 0.0001). Mean total health care costs were higher among patients with a NV claim versus those without evidence of the side effect ($6290 vs $2309; P < 0.0001). Among patients with a recent hospitalization, patients with NV claims had higher rates of 30-day rehospitalization than those with no NV claims (24.4% vs 3.0%; P < 0.0001).ConclusionsAmong outpatients prescribed opioids for management of acute pain, co-prescribing with antiemetics was low, and the economic burden associated with NV was high. Efforts to prevent NV in patients receiving opioid therapy may improve patient outcomes and provide cost savings to the health care system.FundingDaiichi Sankyo, Inc.Electronic supplementary materialThe online version of this article (doi:10.1007/s40122-016-0057-y) contains supplementary material, which is available to authorized users.

show abstract

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Weibel

Jelting

Pace

et al. 2017

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Activity-based cost analysis of opioid-related nausea and vomiting among inpatients

Cited by 13 publications

References 13 publications

Administration of intravenous morphine for acute pain in the emergency department inflicts an economic burden in Europe

Administration of intravenous morphine for acute pain in the emergency department inflicts an economic burden in Europe

Health Care Utilization and Costs Associated with Nausea and Vomiting in Patients Receiving Oral Immediate-Release Opioids for Outpatient Acute Pain Management

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Contact Info

Product

Resources

About