Activity and degeneration in secretory neurones of the hypothalamus and posterior pituitary of the rat

Sloper, J. C.; King, Barbara C.

doi:10.1002/path.1700860122

Cited by 24 publications

(2 citation statements)

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“…Experimentally induced osmoregulatory activity produces a variety of morphological changes in the SON neurons. The volumes of cells, nuclei, and nucleoli increase, the granules stainable with chrome alum hematoxylin phloxine and paraldehyde fuchsin are initially depleted, the Nissl substance is redistributed, and vacuolization of the cells and degenerative changes may occur after prolonged stress (Hillarp, 1949;Ortmann, 1950Ortmann, , 1951Laqueur, 1952;Leveque, 1953;Eichner, 1953;KovAcs et al, 1954;Bachrach, 1957;De Groot, 1957;Stutinsky, 1957;Eichner, 1958, 1960;Campanacci, 1960;Raiha, 1960;Sloper and King, 1963). An antagonism between the renal effects of adrenocortical and neurohypophyseal hormones has been suggested (Silvette and Britton, 1938; for references see Kennedy, 1960).…”

Section: Introductionmentioning

confidence: 99%

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Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Eneström

Hamberger

1968

The Journal of Cell Biology

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The study was undertaken to investigate the possible correlation of total volume of mitochondria per cell with the rate of succinate oxidation in isolated nerve cell bodies, after various functional stresses in the experimental animals. Significant cytological effects were found in the nerve cells of the supraoptic nucleus in rats which had been thirsting for 4-12 days or had been given 2% sodium chloride solution as a substitute for drinking water for a few weeks. Quantitation of mitochondria was done from electron micrographs. The cell volumes were calculated from sections of Epon-embedded tissue under phase-contrast microscopy. Succinate oxidation was measured on groups of 10 nerve cells with the microdiver technique. As a result of either thirst or sodium chloride load, the volume of mitochondria per nerve cell more than doubled. 'The rate of succinate oxidation was not changed after the rats had been thirsting but was enhanced by over 100% after they had drunk sodium chloride. A linear relationship was found for the amount of mitochondria versus respiration in the supraoptic neurons for all experimental groups except the thirsting animals. The mitochondria in the supraoptic neurons from thirsting animals were of the same size or smaller than those in controls, whereas in animals given sodium chloride solution the mitochondria were considerably enlarged. The observed effects were specific for the supraoptic nucleus.

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Section: Introductionmentioning

confidence: 99%

“…There is a depletion of stored octapeptide hormones, mostly vasopressin, from the posterior pituitary lobe after dehydration or salt load has occurred (see Lederis, 1962;Sloper and King, 1963). The ADH activity of the SON was decreased in dogs thirsting for 8-14 days (Hild and Zetler, 1953).…”

Section: Introductionmentioning

confidence: 99%