Pathological Aspects of the Concept of Neurosecretion with Special Reference to the Pathogenesis of Diabetes Insipidus

Sloper, J. C.; Karim, M.Asad; Richards, M. A.

doi:10.1007/978-3-642-87609-7_15

Cited by 4 publications

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“…However, satisfactory pathological studies on the hypothalamo-neurohypophysial system of such patients and quantitative bioassays of oxytocin and vasopressin in this syndrome are lacking [Sloper, 1969]. In a recent review article, Sloper et al [1967] have given the criteria of pathological and physiological aspects of diabetes insipidus in dogs, but without any quantitative information on oxytocin and vasopressin. In this connection, only Sokol and V a l t in [1965] have described the hypothalamo-neurohypophysial system in hereditary hypothalamic diabetes insipidus in rats (Brattleboro strain); in addition, V a l t in et al [1965] estimated the neurohypophysial hormones and found a lack of vasopressin.…”

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confidence: 99%

Neurohypophysial Hormones in the Pars Nervosa of the Mouse with Hereditary Nephrogenic Diabetes Insipidus

Naik¹,

Kobayashi²

1971

Neuroendocrinology

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Vasopressor and oxytocic activities were detectable in the pars nervosa of mice with hereditary diabetes insipidus (DI Os/+ strain). This finding shows that the diabetes insipidus of DI mice is due to a primary defect of the kidney and not to vasopressin deficiency. Both activities of the DI mice were significantly higher than in normal mice (VII +/+) when the activities were expressed in terms of the individual. However, when the activity was expressed per mg of dry weight of the pars nervosa, the difference in oxytocic activity of the two groups seemed to be no longer significant, although vasopressor activity was still greater in the DI mice.

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confidence: 99%