Activity Against Mycobacterium tuberculosis of Alkaloid Constituents of Angostura Bark, Galipea officinalis

Houghton, Peter J.; Woldemariam, Tibebe Z.; Watanabe, Yasuo; Yates, M.D.

doi:10.1055/s-1999-13988

Cited by 133 publications

(62 citation statements)

References 6 publications

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“…As indicated above, there are a number of reports in the literature on in vitro inhibition of growth of mycobacteria by plants used in traditional medicine (Grange and Davey, 1990;Cantrell et al, 1998;Lall and Meyer, 1999). However, relatively few have attempted to isolate the active principle(s) from the bioactive fractions as done by Houghton et al (1999) or Cantrell et al (1999). In contrast to a wide range of tannins showing antimicrobial activity (Scalbert, 1991), compounds that display inhibitory activity against M. tuberculosis belong mainly to the classes of natural products such as terpenoids (sesqui-, di-and triterpenes) and alkaloids but seldom to phenolics.…”

Section: Antimycobacterial Activity Of Ethiopian Plantsmentioning

confidence: 99%

Investigations on antimycobacterial activity of some Ethiopian medicinal plants

Asres

Bučar

Edelsbrunner

et al. 2001

Phytotherapy Research

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Fifteen crude extracts prepared from seven Ethiopian medicinal plants used to treat various infectious diseases were assessed for their ability to inhibit the growth of Mycobacterium tuberculosis. A preliminary screening of the crude extracts against M. tuberculosis typus humanus (ATCC 27294) was done by dilution assay using Löwenstein-Jensen medium. None of the tested extracts except the acetone fraction obtained from the stem bark of Combretum molle (R. Br. ex G. Don.) Engl & Diels (Combretaceae) showed significant inhibitory action against this strain. The acetone fraction of the stem bark of C. molle caused complete inhibition at concentrations higher than 1 mg/mL. Phytochemical analysis of the bioactive fraction led to the isolation of a major tannin and two oleanane-type pentacyclic triterpene glycosides. The tannin was identified as the ellagitannin, punicalagin, whilst the saponins were characterized as arjunglucoside (also called 4-epi-sericoside) and sericoside. All the pure compounds were further tested against the ATCC strain. Punicalagin was found to inhibit totally growth of the ATCC and also of a patient strain, which was fully sensitive to the standard antituberculosis drugs, at concentrations higher than 600 microg/mL and 1.2 mg/mL, respectively. On the other hand, the saponins failed to show any action on the ATCC strain. It appears that our findings are the first report of tannins exhibiting antimycobacterial activity.

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Section: Antimycobacterial Activity Of Ethiopian Plantsmentioning

confidence: 99%

Investigations on antimycobacterial activity of some Ethiopian medicinal plants

Asres

Bučar

Edelsbrunner

et al. 2001

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…97) The ethanolic extract from the bark of G. officinalis, called angostura, possesses activity against Mycobacterium tuberculosis. 98) Recently, the antimalarial and cytotoxic activities of angusturiene, galipeine, cuspareine and galipinine have also been reported (Fig. 5).…”

Section: Mitsuhiro Arisawa Was Born In 1971 Inmentioning

confidence: 96%

Development of Environmentally Benign Organometallic Catalysis for Drug Discovery and Its Application

Arisawa

2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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We have developed a novel organometallic catalysis and applied it to drug discovery. Two new catalysts were found, ruthenium hydride with a nitrogen-containing heterocyclic carbene (A) and an organopalladium catalyst supported on a sulfur-terminated semiconductor, gallium arsenide (001) (B). Both catalysts are environmentally benign, because A can yield indole derivatives with good atom economy, and B can catalyze the Mizoroki-Heck reaction more than 10 times with only trace amounts of leached palladium (ppb level). We also describe our synthetic study of nitrogen-containing heterocycles using ring-closing metathesis (RCM), such as chiral bicyclic lactams, azacycloundecenes, axially chiral macrolactams, 1,2-dihydroquinolines and indoles, including the development of silyl-enol ether ene metathesis, selective isomerization of terminal olefin, enamide metathesis and cycloisomerization and its application to the syntheis of 4 natural products, (؊)-coniceine, (S)-pyrrolam A, angustureine, and fistulosin.

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“…used topically to cure ulcerations of cutaneous leishmaniasis by the native Chimane Indians [3]. These 2-substituted quinolines seem to be specific of the Galipea genus [4][5][6][7]. In 1994, it has been demonstrated that these compounds also exhibit antileishmanial properties after oral administration in an in vivo mouse model of VL [8].…”

Section: Introductionmentioning

confidence: 99%

“…In 1994, it has been demonstrated that these compounds also exhibit antileishmanial properties after oral administration in an in vivo mouse model of VL [8]. In addition to their antileishmanial activity, 2-substituted quinolines isolated from Galipea genus also exhibit antitrypanosomal [9,10] antiretroviral [9][10][11][12], nematocidal [13], trichomonacidal [14], antibacterial [7], molluscicidal [6] and antiplasmodial activities [10,8]. Recently, we synthesized the most active of these compounds, compound 1, as well as two of its derivatives, compounds 2 and 3 ( Fig.…”

Section: Introductionmentioning

confidence: 99%