Investigations on antimycobacterial activity of some Ethiopian medicinal plants

Asres, Kaleab; Bučar, Franz; Edelsbrunner, S.; Kartnig, Theodor; Höger, G.; Thiel, Walter

doi:10.1002/ptr.724

Cited by 66 publications

(54 citation statements)

References 19 publications

(19 reference statements)

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“…Another hydrolysable tannins, punicalagin present in some Ethiopian medicinal plants was active against Mycobacterium tuberculosis strains (Asres et al, 2001). Tannins from Vaccinium vitis-idaea could be used for treatment of periodontal diseases since they have antimicrobial activity against Porphyromonas gingivalis and Prevotella intermedia (Ho et al, 2001).…”

Section: Plants Containing Tanninsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

370

214

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Livestock and aquaculture production is under political and social pressure, especially in the European Union (EU), to decrease pollution and environmental damage arising due to animal agriculture. The EU has banned the use of antibiotics and other chemicals, which have been shown to be effective in promoting growth and reducing environment pollutants because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. As a result of this, scientists have intensified efforts in exploiting plants, plant extracts or natural plant compounds as potential natural alternatives for enhancing the livestock productivity. This paper discusses work on the effects of various phytochemicals and plant secondary metabolites in ruminant and fish species. The focus is on (i) plants such as Ananas comosus (pine apple), Momordica charantia (bitter gourd) and Azadirachta indica (neem) containing anthelmintic compounds and for their use for controlling internal parasites; (ii) plants containing polyphenols and their applications for protecting proteins from degradation in the rumen, increasing efficiency of microbial protein synthesis in rumen and decreasing methane emission; for using as antioxidants, antibacterial and antihelmintic agents; and for changing meat colour and for increasing n-3 fatty acids and conjugated linoleic acid in meat; (iii) saponin-rich plants such as quillaja, yucca and Sapindus saponaria for increasing the efficiency of rumen fermentation, decreasing methane emission and enhancing growth; for producing desired nutritional attributes such as lowering of cholesterol in monogastric animals; for increasing growth of fish (common carp and Nile tilapia) and for changing male to female ratio in tilapia; and for use as molluscicidal agents; (iv) Moringa oleifera leaves as a source of plant growth factor(s), antioxidants, beta-carotene, vitamin C, and various glucosinolates and their degraded products for possible use as antibacterial, antioxidant, anticarcinogenic and antipest agents; (v) Jatropha curcas toxic variety with high levels of various phytochemicals such as trypsin inhibitor, lectin, phytate and phorbol esters in seeds limiting the use of seed meal in fish and livestock diets; and the use of phorbol esters as bio-pesticidal agent; and (vi) lesser-known legumes such as Entada phaseoloides seeds containing high levels of trypsin inhibitor and saponins, Sesbania aculeate seeds rich in non-starch polysaccharides and Mucuna pruriens var. utilis seeds rich in L-3,4-dihydroxyphenylalanine and their potential as fish feed; Cassia fistula seeds as a source of antioxidants; and the use of Canavalia ensiformis, C. gladiata and C. virosa seeds containing high levels of trypsin inhinitor, lectins and canavanine. The paper also presents some challenges and future areas of work in this field.

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Section: Plants Containing Tanninsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

370

214

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“…Several recent reviews emphasize the potential of plant species and natural products as sources of antimycobacterial extracts and chemicals. [12][13][14][15] The structural diversity of plant-derived antimycobacterial compounds is highlighted by the fact that the classes to which these compounds belong include alkaloids, terpenoids, coumarins/chromones, peptides and phenolics.The Ebenaceae is a medium sized family comprising about 500 species but only two genera, Euclea and Diospyros, are Received February 6, 2008; accepted April 15, 2008; published online April 18, 2008 Naphthoquinones and other compounds with antimycobacterial activity against Mycobacterium tuberculosis have previously been isolated from Euclea species. In this study, several constituents of Euclea natalensis and E. undulata, as well as organic extracts of the leaves, were assessed for efficacy against the zoonotic pathogen, Mycobacterium bovis.…”

mentioning

confidence: 99%

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confidence: 99%

Purified Compounds and Extracts from Euclea Species with Antimycobacterial Activity against Mycobacterium bovis and Fast-Growing Mycobacteria

McGaw

Lall

Hlokwe

et al. 2008

Biological & Pharmaceutical Bulletin

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Tuberculosis (TB) in humans, caused by Mycobacterium tuberculosis, is a chronic infectious disease, with approximately one-third of the world's population estimated by the WHO to be infected. 1) In 2003, 1.7 million people died of TB and of these, 99% of cases were reported in developing countries.1) Other organisms belonging to the M. tuberculosis complex include M. bovis, M. africanum and M. microti.Bovine TB (causal organism Mycobacterium bovis) is an important zoonotic disease that can spread to humans by inhalation of infectious droplet nuclei and by ingestion of milk which has not been pasteurized or boiled.2) People regularly exposed to either livestock infected with bovine TB or infected products, such as poorly heat-treated meat and unpasteurised milk, should be considered at risk of contracting zoonotic infections. 3,4) This risk increases considerably in HIV-infected individuals.5) The occurrence of M. bovis disease by reactivation or primary infection in HIV-infected patients, and the transmission from patients with infectious pulmonary M. bovis disease to immune-competent individuals is a health concern.2)In developed countries, the prevalence of bovine TB has been significantly reduced by control (test and slaughter) programmes, but complete eradication of the disease is made difficult by reservoirs in wildlife. In the developing world, the combination of the HIV epidemic, poor living conditions and a high burden of tuberculosis in animals is a significant obstacle to control of M. bovis in several African countries.2)The zoonotic effects of M. bovis, especially with regard to immunocompromised individuals, have not been comprehensively studied and it is anticipated that this may be an increasingly serious problem, particularly in sub-Saharan Africa. Underdiagnosis of M. bovis infection is potentially widespread, as many laboratories do not use the specialized diagnostic techniques required to distinguish between the genetically similar M. bovis and M. tuberculosis.3,6) M. bovis is believed to account for up to 10% of cases of human TB worldwide.7) In developing countries with no active bovine TB control programmes, a serious threat to human health is posed.8) More than 94% of the world's population occurs in countries with no strategies in place to control M. bovis infections.9) In terms of public health, as well as economics, bovine TB control or eradication programmes should be a major target of affected countries. 10)With the rising incidence of drug resistance to existing TB drugs, as demonstrated by the occurrence of multi-drug resistant (MDR) strains of M. tuberculosis and the recent outbreak in South Africa of extreme drug resistant TB (XDR-TB), 11) the search for new anti-TB drug leads is achieving new urgency. Although MDR strains of M. bovis have been identified, case reports show that anti-TB drugs routinely used to treat M. tuberculosis-infected patients are effective when properly administered.2) It is, however, likely that resistance to currently used drugs will develop if the incide...

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“…Tuberculosis (TB) is still a serious illness and a serious public health problem with medical, sociological and economic consequences that has a fatal end in more than 50% of untreated cases [24] and the importance of rapid availability of M. tuberculosis drug resistance results is universally acknowledged due to the problem of resistance [25], henceforth finding healing properties in plants is an ancient idea that is coming up again [26]. In the current study, the focus was to assess the anti-mycobacterial activity of T. ivorensis, C. procera, F. macrophylla, A. occidentale, Ficus spp.…”

Section: Discussionmentioning

confidence: 99%

Comparative Anti-mycobacterial Activity on Lowenstein-Jensen Slants of Selected Medicinal Plants Used in the Congolese Pharmacopeia

Bongo¹

2017

JDMP

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Abstract:Tuberculosis is an infectious disease that kills approximately three million people annually worldwide. The emergence of multidrug resistant, extensively drug resistant and lengthy therapy reduces the patient compliance and therefore comprises control strategies. In this study, the leaves of Terminalia ivorensis, Carapa procera, Fagara macrophylla, Anacardium occidentale, Ficus spp. and Drepanoalpha® (a polyherbal medicine to relieve sickle cell anaemia) were extracted with petroleum ether, ethyl acetate and methanol in order to screen potential bioactive compounds in different extracts and to assess their anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium tuberculosis spp. on Lowenstein-Jensen medium using a qualitative approach. The activity was determined as to whether there was growth or not. It was shown that only the methanolic extract displayed a good activity on both strains than the petroleum ether and ethyl acetate extracts. The presence of phytochemicals in plants such as alkaloids, flavonoids, tannins, saponins, anthocyanins and quinones known to be of medicinal importance pointed out a possible source for anti-mycobacterial agents to address the problem of multidrug resistance. The in vitro findings of this study provide a partial support for the use of these plants in the control of various infectious diseases as lead to drug discovery and should be reiterated and recommended for a clinical trial using an animal model.

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Investigations on antimycobacterial activity of some Ethiopian medicinal plants

Cited by 66 publications

References 19 publications

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Purified Compounds and Extracts from Euclea Species with Antimycobacterial Activity against Mycobacterium bovis and Fast-Growing Mycobacteria

Comparative Anti-mycobacterial Activity on Lowenstein-Jensen Slants of Selected Medicinal Plants Used in the Congolese Pharmacopeia

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