Activities of Daily Living and Depressive Symptoms in Patients with Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer’s Disease

Stögmann, Elisabeth; Moser, Doris; Klug, Stefanie; Gleiß, Andreas; Auff, Eduard; Dal‐Bianco, Peter; Pußwald, Gisela; Lehrner, Johann

doi:10.3233/jad-150785

Cited by 51 publications

(84 citation statements)

References 25 publications

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“…Similar to previous findings [33], we identified a high prevalence of depressive symptoms in SCI. However, in our sample current depressive symptoms were not more prevalent in SCI than in MCI, and were thus not a characteristic specific for SCI patients.…”

Section: Discussionsupporting

confidence: 80%

“…However, in our sample current depressive symptoms were not more prevalent in SCI than in MCI, and were thus not a characteristic specific for SCI patients. The prevalence of current depressive symptoms in our study (SCI: 13.3%; MCI: 15%) was lower than what was reported in a similar although smaller memory clinic sample by Elfgren et al [11] (SCI: 33%; MCI 27%) and in a similar memory clinic study assessing depressive symptoms by questionnaire [33] (SCI: 45.5%; MCI: 42-50%). It was also lower than the median value of 44.3% depressive symptoms in MCI patients in hospital-based studies [34].…”

Section: Discussioncontrasting

confidence: 54%

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High Prevalence of Stress and Low Prevalence of Alzheimer Disease CSF Biomarkers in a Clinical Sample with Subjective Cognitive Impairment

Eckerström¹,

Berg²,

Nordlund³

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Subjective cognitive impairment (SCI) is a trigger for seeking health care in a possible preclinical phase of Alzheimer's disease (AD), although the characteristics of SCI need clarification. We investigated the prevalence of psychosocial stress, depressive symptoms and CSF AD biomarkers in SCI and MCI (mild cognitive impairment). Methods: Memory clinic patients (SCI: n = 90; age: 59.8 ± 7.6 years; MCI: n = 160; age: 63.7 ± 7.0 years) included in the Gothenburg MCI study were examined at baseline. Variables were analyzed using logistic regression with SCI as dependent variable. Results: Stress was more prevalent in SCI (51.1%) than MCI (23.1%); p < 0.0005. SCI patients had more previous depressive symptoms (p = 0.006), but showed no difference compared to MCI patients considering current depressive symptoms. A positive CSF AD profile was present in 14.4% of SCI patients and 35.0% of MCI patients (p = 0.001). Stress (p = 0.002), previous stress/depressive symptoms (p = 0.006) and a negative CSF AD profile (p = 0.036) predicted allocation to the SCI group. Conclusion: Psychosocial stress is more prevalent in SCI than previously acknowledged. The high prevalence and long-term occurrence of stress/depressive symptoms in SCI in combination with a low prevalence of altered CSF AD biomarkers strengthens the notion that AD is not the most likely etiology of SCI.

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Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 54%

High Prevalence of Stress and Low Prevalence of Alzheimer Disease CSF Biomarkers in a Clinical Sample with Subjective Cognitive Impairment

Eckerström¹,

Berg²,

Nordlund³

et al. 2016

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…This confirmed the efficacy of this system, which was designed to alleviate disturbed attention and concentration, and suggests that cognitive impairment was alleviated through increasing attention and concentration. The N-ADL score after the intervention, on the other hand, was shown to be significantly associated with the change in MMSE score, supporting the previous findings [13,14] that cognitive impairment is associated with impaired ADL in dementia. During this intervention program, the subjects were not spoken to, so that their concentration was focused on the task at hand.…”

Section: Discussionsupporting

confidence: 79%

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial

Okamura¹,

Otani²,

Shimoyama³

et al. 2018

Dement Geriatr Cogn Disord

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Background/Aims: We investigated the efficacy of a combined exercise and cognitive training system that we devised for improvement of attention and concentration, cognition, and activities of daily living in older adults with dementia. Methods: A total of 100 dementia patients were randomly assigned to an intervention group or a control group. The intervention group was subjected to a combined exercise and cognitive training for 6 consecutive weeks. Evaluations were performed using the Trail Making Test-Part A, the Mini-Mental State Examination, and an N-type activities of daily living evaluation scale for the elderly. Results: A comparison of the changes in scores on the evaluation scales between the intervention group and the control group showed significant interactions for all scores. Conclusions: The combined system is effective in increasing attention and concentration and improving cognitive function and activities of daily living in dementia patients.

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“…Furthermore, there were no measures of insight or informant concerns included in this study, which could add further information about other factors that might mediate the relationship between SCD and objective cognitive performance. As many previous studies have shown, the influence of depressive symptomatology on subjective, metacognitive monitoring and self-reflective measures cannot be discounted [3, 25, 30]. It is possible that early signs of both depressive symptoms and greater SCD in cognitively-normal older adults may well be indicative of overall ‘illness’ due to a milieu of disease-related effects [31], and thus represent greater risk of progression to dementia.…”

Section: Discussionmentioning

confidence: 99%

Assessing Error Awareness as a Mediator of the Relationship between Subjective Concerns and Cognitive Performance in Older Adults

et al. 2016

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ObjectivesSubjective concerns of cognitive decline (SCD) often manifest in older adults who exhibit objectively normal cognitive functioning. This subjective-objective discrepancy is counter-intuitive when mounting evidence suggests that subjective concerns relate to future clinical progression to Alzheimer’s disease, and so possess the potential to be a sensitive early behavioural marker of disease. In the current study, we aimed to determine whether individual variability in conscious awareness of errors in daily life might mediate this subjective-objective relationship.Methods67 cognitively-normal older adults underwent cognitive, SCD and mood tests, and an error awareness task.ResultsPoorer error awareness was not found to mediate a relationship between SCD and objective performance. Furthermore, non-clinical levels of depressive symptomatology were a primary driving factor of SCD and error awareness, and significantly mediated a relationship between the two.DiscussionWe were unable to show that poorer error awareness mediates SCD and cognitive performance in older adults. Our study does suggest, however, that underlying depressive symptoms influence both poorer error awareness and greater SCD severity. Error awareness is thus not recommended as a proxy for SCD, as reduced levels of error awareness do not seem to be reflected by greater SCD.

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Activities of Daily Living and Depressive Symptoms in Patients with Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer’s Disease

Cited by 51 publications

References 25 publications

High Prevalence of Stress and Low Prevalence of Alzheimer Disease CSF Biomarkers in a Clinical Sample with Subjective Cognitive Impairment

High Prevalence of Stress and Low Prevalence of Alzheimer Disease CSF Biomarkers in a Clinical Sample with Subjective Cognitive Impairment

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial

Assessing Error Awareness as a Mediator of the Relationship between Subjective Concerns and Cognitive Performance in Older Adults

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