ACTIVIDADE ANTIMICROBIANA E EFEITO COMBIANDO SOBRE DROGAS ANTIFÚNGICAS Y ANTIBACTERIANAS DO FRUTO DE Morinda citrifolia L.

Abstract

RESUMOO aparecimento de micro-organismos resistentes e a toxicidade associada aos fármacos antimicrobianos aumentam a necessidade de pesquisas por novos princípios ativos. Morinda citrifolia L., uma planta frutífera utilizada popularmente como antibacteriano e com diversos outros usos farmacológicos. Possui diversos metabólitos primários e secundários, principalmente flavonóides, triterpenóides e alcalóides. O presente trabalho visou testar o potencial antimicrobiano e modulador dos extratos do seu fruto. Os extratos do fruto foram testados quanto ao seu efeito antimicrobiano e em combinação com antibacterianos e antifúngicos contra microrganismos patógenos pelo método de microdiluição em caldo. Observou-se que as associações entre antibióticos e extratos mostraram resultados com relevância clínica diante dos testes com bactérias Pseudomonas aeruginosa e Escherichia coli.Palavras-chave: efeito modulador, extratos, metabolitos secundários, multirresistente. ABSTRACTThe rising of the drug resistant microrganisms and the toxicity related with the antimicrobial drugs enhances the necessity about the search of new bioactive compounds. Morinda citrifolia L. is a fruit tree traditionally used as antibacterial and with several other pharmacological properties. This plant presents several phytocompounds as flavonoids, alkaloids and triterpenes. The objective of this work was assay the antimicrobial and modulatory potential of the fruit extract. The extract was assayed alone and associated with antibiotics and antifungals against pathogenic microrganisms using the microdilution assay. The results demonstrated that the association between extract and antimicrobial drugs resulted in a potentiation of the drug activity clinically relevant against Pseudomonas aeruginosa and Escherichia coli.

Antifungal activity of Gallesia integrifolia fruit essential oil

“… 13 Thus, the search for new antimicrobial molecules are of interest for public health as well as for the maintenance and broadening of food product and an alternative to reduce microbial resistance. 14 , 15 , 16 , 17 …”

“…These chemical compounds can be toxic and their residues can have carcinogenic and teratogenic side effects 13 . Thus, the search for new antimicrobial molecules are of interest for public health as well as for the maintenance and broadening of food product and an alternative to reduce microbial resistance 14, 15, 16, 17…”

Botanical fungicides in the control of soybean leaf diseases / Fungicidas botânicos no controle de doenças foliares na soja

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Cytotoxic, antimicrobial and healing activity of the Jatropha gossypiifolia L extract.

“…According to data from the World Health Organization, 25% of the world's deaths are due to infectious diseases. 2 Wound care is part of the Nursing care attributions, with a large number of studies published in this area, demonstrating the important role and responsibility of nurses in this process and in the search for new ways of care, attentive to the innovations of care in this area, to improve the quality of care. 3 In this way, the use of therapies, other than conventional therapies, such as the use of herbal medicines, extracts or, even medicinal plants in natura, for wound healing, has been increased, in recent years, by the search for active principles isolated from plants, that have an effective role in the healing process.…”