Actividad fotodinámica de ftalocianina de aluminio (iii) y zinc (ii) en promastigotes de Leishmania

Escobar, Patricia; Hernández, Indira Paola; Rueda, Cesar M.; Martı́nez, Fernando; Páez, Edgar

doi:10.7705/biomedica.v26i1.1499

Cited by 28 publications

(12 citation statements)

References 36 publications

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“…As the functionality differs, its reactivity also differs in in vitro studies ( Sobotta et al, 2018 ). PDT primarily depend on the cell which is used for the examination, types of the Pcs, cell uptake, intensity of light, Pc’s incubation time, or localization in the target cell ( Paquette et al, 1988 ; Rosenthal and Ben-Hur, 1995 ; Escobar et al, 2012 ). The above-mentioned features are possessed by Al(III) phthalocyanine complexes and hence improve the results of PDT activity.…”

Section: Resultsmentioning

confidence: 99%

Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

Nemakal

Managa

et al. 2021

Front. Chem.

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N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.

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Section: Resultsmentioning

confidence: 99%

Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

Nemakal

Managa

et al. 2021

Front. Chem.

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“…Vitamin D is photosensitive with direct photochemical degradation by mechanisms involving photosensitizers that generate ROS or by indirect effects of light that lead to lipid oxidation, facilitating the action of PDT [28]. Pcs are strong candidates for use in PDT due to their efficient incorporation into target cells, high triplet yields, and optimal tissue penetration by light owing to their high absorption coefficients at the range of 650 to 680 nm [10] [29] [30]. Pcs include zinc-phthalocyanine (ZnPc), tetrasulfonated aluminum phthalocyanine (AlPcS4), and chloroaluminum phthalocyanine (AlPcCl), which are used to evaluate oxidative stress in cell lines after photodynamic antimicrobial chemotherapy or the antimicrobial activity of the compounds [11] [26] [30].…”

Section: Discussionmentioning

confidence: 99%

“…Pcs are strong candidates for use in PDT due to their efficient incorporation into target cells, high triplet yields, and optimal tissue penetration by light owing to their high absorption coefficients at the range of 650 to 680 nm [10] [29] [30]. Pcs include zinc-phthalocyanine (ZnPc), tetrasulfonated aluminum phthalocyanine (AlPcS4), and chloroaluminum phthalocyanine (AlPcCl), which are used to evaluate oxidative stress in cell lines after photodynamic antimicrobial chemotherapy or the antimicrobial activity of the compounds [11] [26] [30]. Previous results suggest that porphyrins are effective in the treatment of leishmaniasis by PDT [31].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Pinto¹,

Silva²,

Sampaio³

et al. 2020

JBM

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Background: Photodynamic therapy (PDT) is the generation of cytotoxic agents through the dynamic interaction between a photosensitizer excited by light at a specific wavelength. When associated with phthalocyanines, they are efficient in incorporating target cells and exhibiting high rates of triplet generation. This study aimed to characterize PDT associated with the phototherapeutic agent Phthalomethyl D, developed by the authors, in the process of repair, healing and immune improvement for possible application against SARS-CoV-2. Methods: Sixty-nine mice were used, divided into 2 groups: GI, treated with ILIB laser, without a phototherapeutic agent, and subjected to surgery for viral induction; GII, same as GI plus association of Phthalomethyl D. They were divided into subgroups and reevaluated at 7, 14, and 21 days, and then divided into 3 subgroups of 6 animals each, subjected to treatment at 24 h, 48 h, 72 h, 5 and 7 days. Results: Both groups had a high rate of partial incision closure and acute inflammatory control. Microscopically, there was a greater amount of amorphous fundamental substance, fibrocytes, fibroblasts, and giant cells and reduction in the number of keratinocytes, in the amount of keratin, and epidermal thickness in GII than in GI. Conclusions: PDT with Phthalomethyl D stimulates the processes of healing/repair and immunomodulation during viral infection, initially favoring the inflammatory response and, after

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“…L. (L.) infantum promastigotes were more photosensitive to exogenous PpIX than L. (V.) panamensis promastigotes, demonstrating once again the interspecies intrinsic variation in drug sensitivity showed by some antileishmanial drugs, such as miltefosine, to which L. donovani (the main species involved in Old World leishmaniasis) was more sensitive than other Leishmania species. Leishmania parasites have been photosensitive to different exogenous photosensitizers like Al and Zn phthalocyanines, carboporphyrins, and benzophenoxazine (10,16,25,26).…”

Section: Discussionmentioning

confidence: 99%

Acumulación celular y el efecto de anti-Leishmania de protoporfirina IX exógena y endógena después del tratamiento fotodinámico

Mateus¹,

Valdivieso²,

Hernández³

et al. 2014

biomedica

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participated in the design and development of the in vitro assays, cell culture, confocal microscopy, drug screening and statistical analysis. Fernando Martínez and Edgar Páez participated in compound characterization and spectrophotometric tests of the stability of PpIX solutions. Patricia Escobar directed the research, designed the protocols and led the statistical analysis and results interpretation. All authors contributed in the analysis and writing of the article.

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Actividad fotodinámica de ftalocianina de aluminio (iii) y zinc (ii) en promastigotes de Leishmania

Cited by 28 publications

References 36 publications

Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Acumulación celular y el efecto de anti-Leishmania de protoporfirina IX exógena y endógena después del tratamiento fotodinámico

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