Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Pinto, Marcus Viní­cius de Mello; Silva, Carlos Henrique Machado Bittencourt; Sampaio, Aline Ronis; Baron, Miriam Viviane; Sancho, Alexandre Gomes; Fortuny, Esteban; Silva, Lizia Fabiola Almeida; Picariello, Felice; Carvalho, Rogério Mendonça de

doi:10.4236/jbm.2020.810010

Cited by 3 publications

(3 citation statements)

References 43 publications

(40 reference statements)

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“…It is obvious that vitamin D plays an important role in the therapeutic management of patients suffering from COVID-19; however other approaches such as photo-biomodulation therapy are currently being investigated. For example, PDT with Phtalomethyl D stimulates the healing/repair and immunomodulation processes during viral infection [28].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in Côte d’Ivoire

Boyvin¹,

Yayé²,

Bahi³

et al. 2022

AiM

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In 2019, the coronavirus pandemic broke out as a serious public health issue worldwide. In Côte d'Ivoire, the number of cases of COVID-19 has increased rapidly. The Severe Acute Respiratory Syndrome virus (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) receptors in the respiratory tracts and enters the respiratory and alveolar cells of infected patients. Deficiency of fat-soluble vitamin D 3 is associated with respiratory distress syndrome and pulmonary fibrosis by activation of the renin-angiotensin system. In Côte d'Ivoire, very little research is being done on SARS-CoV-2 and vitamin D. The objective of this study was to assess the vitamin D status of people infected and suffering from COVID-19 in order to contribute to their medical treatment. The study involved 100 adults infected with SARS-CoV-2 (24 women and 76 men). After confirmation of the patient's SARS-CoV-2 status by RT-PCR, the 25 (OH) vitamin D assay was performed on the Cobas 6000 device and compared to control subjects, the non-COVID-19 positive. A significant decrease in 25-hydroxy vitamin D 3 concentrations (44 ± 1.29 nmole/L) was observed in patients infected with SARS-CoV-2, compared to control (78 ± 0.68 nmole/L) (p < 0.0001). The 25-hydroxy vitamin D 3 deficiency requires vitamin D supplementation in the management of hospitalized patients infected with SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in Côte d’Ivoire

Boyvin¹,

Yayé²,

Bahi³

et al. 2022

AiM

View full text Add to dashboard Cite

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“…This can also be seen in the association of PDT with Phthalocyanines, a phototherapeutic agent that makes incorporation by target cells easier. The use of phototherapeutic agent Phthalomethyl D shows promising effects if used with the aim of leading to immunological improvement, cure, and repair against viral induction [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the relationship between the action of the laser and the activation of monocytic cells may explain the process of resolving systemic inflammation with more efficient wound closure. Thus, its contribution to the anti-inflammatory response during viral infection may be an approach to SARS-CoV-2 [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review

Matos

Buchaim

Pomini

et al. 2021

Life

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COVID-19 is a viral disease characterized as a pandemic by the World Health Organization in March 2020. Since then, researchers from all over the world have been looking for ways to fight this disease. Many cases of complications arise from insufficient immune responses due to low immunity, with intense release of pro-inflammatory cytokines that can damage the structure of organs such as the lung. Thus, the hypothesis arises that photobiomodulation therapy (PBMT) with the use of a low-level laser (LLLT) may be an ally approach to patients with COVID-19 since it is effective for increasing immunity, helping tissue repair, and reducing pro-inflammatory cytokines. This systematic review was performed with the use of PubMed/MEDLINE, Web of Science, Scopus and Google Scholar databases with the following keywords: “low-level laser therapy OR photobiomodulation therapy AND COVID-19”. The inclusion criteria were complete articles published from January 2020 to January 2021 in English. The exclusion criteria were other languages, editorials, reviews, brief communications, letters to the editor, comments, conference abstracts, and articles that did not provide the full text. The bibliographic search found 18 articles in the Pubmed/MEDLINE database, 118 articles on the Web of Science, 23 articles on Scopus, and 853 articles on Google Scholar. Ten articles were included for qualitative synthesis, of which four commentary articles discussed the pathogenesis and the effect of PBMT in COVID-19. Two in vitro and lab experiments showed the effect of PBMT on prevention of thrombosis and positive results in wound healing during viral infection, using the intravascular irradiation (ILIB) associated with Phthalomethyl D. Two case reports showed PBMT improved the respiratory indexes, radiological findings, and inflammatory markers in severe COVID-19 patients. One case series reported the clinical improvement after PBMT on 14 acute COVID-19 patients, rehabilitation on 24 patients, and as a preventive treatment on 70 people. One clinical trial of 30 patients with severe COVID-19 who require invasive mechanical ventilation, showed PBMT-static magnetic field was not statistically different from placebo for the length of stay in the Intensive Care Unit, but improved diaphragm muscle function and ventilation and decreased the inflammatory markers. This review suggests that PBMT may have a positive role in treatment of COVID-19. Still, the necessity for more clinical trials remains in this field and there is not sufficient research evidence regarding the effects of PBMT and COVID-19 disease, and there is a large gap.

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Photobiomodulation Therapy in Mitigating the Risk of SARS CoV-2 Infection by Enhancing Biodiversity of Oral Microbiome-A Conceptual Hypothesis Based on Scoping Review

Hosmani

Alqarni

Yavagal³

et al. 2023

sci adv mater

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Since March 2020, scientists across the globe are looking for ways to combat COVID-19, a viral disease of recent times which was declared Pandemic by WHO. Mounting an incompetent immune reverberation and the surge in pro-inflammatory cytokines are the main cause for complications. Hence, it is hypothesized that photobiomodulation therapy (PBMT) using low-level light therapy (LLLT) might be a successful therapeutic treatment for COVID-19 victims since it has been shown to be successful in enhancing immunity, aiding in tissue healing, and reducing pro-inflammatory cytokines. The goal of this scoping review is to investigate the potential use of PBMT as a promising neo-strategy for an alternative therapy for the treatment of patients with COVID-19 in light of the significance of underlying pathways in the mitigation, therapeutic interventions, and recovery of chronic diseases like COVID-19. The findings of the review revealed that PBMT using a low-level laser has been proven to be effective in treating COVID-19’s initial stages and prevent the progression to severe form of the disease. This approach needs to be confirmed by clinical trials and larger studies that include a wider population. Because of its proven effectiveness in reducing inflammation, thrombosis and accelerate wound healing, PBMT may be a promising approach to reduce the severity of COVID-19, especially in the lungs. Based on the findings of the review, we propose a novel hypothesis of utilizing PBMT to enhance the biodiversity of oral microbiome which will help in extenuating the imperilment of SARS CoV-2 infection.

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Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Cited by 3 publications

References 43 publications

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in Côte d’Ivoire

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in Côte d’Ivoire

Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review

Photobiomodulation Therapy in Mitigating the Risk of SARS CoV-2 Infection by Enhancing Biodiversity of Oral Microbiome-A Conceptual Hypothesis Based on Scoping Review

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Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Cited by 3 publications

References 43 publications

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in C&#244;te d’Ivoire

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in C&#244;te d’Ivoire

Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review

Photobiomodulation Therapy in Mitigating the Risk of SARS CoV-2 Infection by Enhancing Biodiversity of Oral Microbiome-A Conceptual Hypothesis Based on Scoping Review

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SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in Côte d’Ivoire

SARS-CoV-2 Infection Is Associated with Vitamin D Deficiency in Côte d’Ivoire