ACTIVIDAD ANTIOXIDANTE DE ALCALOIDES DE Erythrina americana Miller

Estrada, Emmanuel Ibarra; Sánchez, Maribel Pacheco; Mateos, Rosario García; Chávez, Rubén San Miguel; Valverde, Gustavo Ramírez; Hernández, Ramón Marcos Soto

doi:10.35196/rfm.2011.4.241

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Qualitative phytochemical analyses of both methanolic extracts from P. incanum showed similar results to two previously reported methanolic extracts from Parthenium hysterophorus leaves [28,30]. Fractionation by column chromatography and their subsequent comparison of the fractions obtained by TLC allows us to obtain some specific regions and the compound of the plant under study [16]. Regarding this, column chromatography techniques have been widely used as purification techniques for successful fractionation and isolation of desired bioactive compounds from complex extract material; this is due to their simplicity, convenience, specificity, economy, and availability to be used in multiple mobile phases with different polarity.…”

Section: Discussionsupporting

confidence: 81%

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Trypanocidal Activity of Compounds Isolated From Parthenium incanum Kunth

Hernández-Marín,

Castro-Rios,

Chavez-Montes

et al. 2023

Preprint

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Parthenium incanum (Mariola) is used in Mexico to treat stomach and liver disorders. Reports have shown that the genus Parthenium contains biologically active metabolites. This work aimed to isolate and identify biologically active compounds with trypanocidal activity. The extracts were obtained through static maceration and extraction with successive reflux using different solvents. After that, they were fractionated with column chromatography, and the obtained fractions were compared by TLC; similar fractions were pooled and concentrated. A bioguided assay was performed with S. aureus ATCC 25923, using agar diffusion techniques and bioautography to determine preliminary biological activity. Active fractions were obtained and purified from a preparative TLC plate. The obtained compounds were identified as parthenin and coronopolin by TLC, FT-IR, and HPLC-MS. Finally, they were evaluated against the Ninoa strain of Trypanosoma cruzi, obtaining an IC50 of up to 45±2.5 ppm. It was concluded that P. incanum contains compounds with trypanocidal activity.

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Section: Discussionsupporting

confidence: 81%

“…Similarities between fractions were evaluated by thin layer chromatography (TLC), using aluminum foils with silica gel 60 F254 (Merck, Darmstadt, Germany). Similar fractions were combined [16].…”

Section: Chromatographic Separationmentioning

confidence: 99%

Trypanocidal Activity of Compounds Isolated From Parthenium incanum Kunth

Hernández-Marín,

Castro-Rios,

Chavez-Montes

et al. 2023

Preprint

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“…Other compounds, such as helindicine and lycopsamine, both alkaloids, containing a laconic ring in their structuret, [31] erisodine, hydroxyerisodine, melosmine, and O-Methyl-moschatoline, with the presence of the oxaporphine nucleus, have an expressive capacity to capture the DPPH radical. [32] Capturing the activity of reactive oxygen species (ROS) in alkaloid groups may be related to the exceptional redox property conferred to nitrogen, [16,17,20] present in the structures of these secondary metabolites. Treatment of AD through antioxidant therapies can prevent or at least attenuate organic deterioration due to excessive oxidative stress.…”

Section: Constituents Identified In Commercial P Boldus Samplesmentioning

confidence: 99%

Chemical and Biological Evaluation of the Aqueous Extract of Peumus boldus Molina (Monimiaceae) Leaves

Silva¹,

Lopes²,

Maia³

et al. 2021

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Background: Traditional medicine has inspired the scientific community to discover natural compounds with the ability to inhibit the enzyme acetylcholinesterase (AChE) and with significant antioxidant capacity. These themes are associated with therapeutic processes to decrease the symptoms of Alzheimer's disease (AD). Acetylcholine (Ach) is an important neurotransmitter in the central nervous system responsible for transmitting the nervous impulse and increasing intestinal motility and dilation of sphincters in the gastrointestinal tract. As the species Peumus boldus Molina is widely known and used in folk medicine to treat gastrointestinal discomfort, its constituents could have an affinity for AChE and could be used to treat AD. Materials and Methods: This study evaluated the chemical, inhibitory activity of AChE (using the Elmann method and in silico), antioxidant capacity (DPPH, ABTS, FRAP, and oxidation inhibition of the β-carotene/linoleic acid system), and quantification of total leaf phenols from a commercial sample of P. boldus. Results: The mass spectral analysis allowed identification of the alkaloids isoboldine, boldine, clocaurine, laurotetanine, N-methylurotetanine, reticuline, and N-methylcoclaurine. In the in silico prediction test, the alkaloid N-metillaurotetanine was the best acetylcholinesterase enzyme inhibitor, with energy of -10.1 kcal mol -1 . Conclusion: These results are of scientific relevance for the discovery of new drugs to treat dementia associated with Alzheimer's disease and stimulate the continuity of chemical and biological studies (anticholinesterase and antioxidant action) of prepurified fractions and substances isolated from P. boldus leaves.

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The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies

Rambo

Biegelmeyer

Toson

et al. 2019

Phytotherapy Research

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Erythrina L. genus (Fabaceae) comprises about 115 species, and it has been extensively studied, mainly because of its alkaloids, which have pharmacological properties. References demonstrated that Erythrina spp. have a potential to act in the central nervous system, presenting anxiolytic and anticonvulsant properties already established. Phytochemical investigations confirmed the presence of tetracyclic alkaloids as the major compounds. However, other alkaloid classes have also been reported, including dimeric and trimeric substances, coupled through direct polymerization or two erythrinine units via an acetyl glucose. The present review covers the relevant literature from 1990 until 2017 and outlines the current data on chemical composition and preclinical and clinical studies on Erythrina species. Additionally, the quite striking analogy in the biosynthetic route of erythrin, morphinans, and Amaryllidaceae family alkaloids was also discussed.

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ACTIVIDAD ANTIOXIDANTE DE ALCALOIDES DE Erythrina americana Miller

Cited by 4 publications

References 9 publications

Trypanocidal Activity of Compounds Isolated From Parthenium incanum Kunth

Trypanocidal Activity of Compounds Isolated From Parthenium incanum Kunth

Chemical and Biological Evaluation of the Aqueous Extract of Peumus boldus Molina (Monimiaceae) Leaves

The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies

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