Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

Elshafie, Amir I.; Elkhalifa, Abdalla D.; Elbagir, Sahwa; Aledrissy, Mawahib; Elagib, Elnour Mohammed; Nur, Musa A. M.; Weitoft, Tomas; Rönnelid, Johan

doi:10.3899/jrheum.160303

Cited by 20 publications

(19 citation statements)

References 43 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recently published a paper characterizing a Sudanese cross-sectional RA cohort and comparing disease activity, treatment, and occurrence of IgM RF among Sudanese and Swedish RA patients [10]. Nothing has been published to date concerning the diagnostic and prognostic properties of anti-CCP2 and RF isotypes in Sudanese RA patients.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis

Elshafie

Elbagir

Aledrissy³

et al. 2019

Clin Rheumatol

Self Cite

View full text Add to dashboard Cite

Objective Anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2) and rheumatoid factor (RF) in rheumatoid arthritis (RA) has been extensively assessed in industrialized countries. We investigated the diagnostic and prognostic impact of anti-CCP2 and RF isotypes in a Sudanese cross-sectional RA cohort. Methods Consecutive RA patients (n = 281) diagnosed according to the 1987 ACR criteria were included 2008-2010. Anti-CCP2 and RF isotypes (IgA, IgM, and IgG) were measured by enzyme immunoassay in 262 patients, with reference intervals aligned to the same diagnostic specificity as for anti-CCP2 (97.6%) using national controls. Results IgA RF was the predominant RA-associated autoantibody (56%), followed by IgM RF and anti-CCP2 (both 52%) and IgG RF (49%). In receiver operator characteristic analysis, IgA RF also showed the largest area under the curve. Patients with IgG RF were younger and had 8 years lower median age of disease onset compared to antibody negative patients (p < 0.0001). IgG RF was the only marker associated with a high number of involved joints (p = 0.028), and together with anti-CCP2 were the strongest markers for finger deformities (p = 0.016 and p = 0.012), respectively. No statistical differences were found for disease duration, ESR and Hb levels, and occurrence of erosions/osteopenia for any of the investigated autoantibodies. Conclusion Whereas IgA RF showed the best diagnostic performance, IgG RF associated with low age of RA onset, high number of involved joints, and finger deformities. These findings indicate that RA-associated antibodies other than conventional IgM RF and anti-CCP2 might be informative in non-Caucasian RA populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis

Elshafie

Elbagir

Aledrissy³

et al. 2019

Clin Rheumatol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The more recent studies in this region show a very active illness with a structural damage combined by an important functional reverberation, a strong seropositivity to the rheumatoid factor and to the anti-CCP antibodies [27]. This severe phenotype of RA also seems to be the case in some East African regions [9]. Elshafie et al, in comparing some Sudanese and Swedish patients suffering from RA note that the Sudanese presented the more laborious inflammatory signs, the X-ray erosions and more severe articular deformations [9].…”

Section: Discussionmentioning

confidence: 96%

“…This severe phenotype of RA also seems to be the case in some East African regions [9]. Elshafie et al, in comparing some Sudanese and Swedish patients suffering from RA note that the Sudanese presented the more laborious inflammatory signs, the X-ray erosions and more severe articular deformations [9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

Niasse¹,

Kane²,

Ndiaye³

et al. 2017

OJIM

View full text Add to dashboard Cite

Introduction: We assess the severity of the rheumatoid arthritis in a Senegalese African black population. Patients and methods: It is a retrospective study achieved in the service of Internal Medicine of Aristide Le Dantec teaching hospital of Dakar between January 2005 and December 2016 in patients suffering from rheumatoid arthritis. We specified for every patient the predictive data of severity of the rheumatoid arthritis. Results: Four hundred and three patients have been gathered (39 men and 364 women), with the mean age of 45.8 years. An active tobacco addiction was noticed in 10 patients. The diagnostic delay was on average of 72 months. Characteristic articular deformations were noticed in 215 patients (53.3%). They were correlated to male (p = 0.038), to age (p = 0.001) and to the activity of the rheumatoid arthritis (p = 0.0445). Systemic manifestations have been observed in 213 cases (52.9%), particularly anemia (50.8%). They were correlated to the anti-CCP antibodies (p = 0.047). The ESR was increased at the first hour in 84.4% of cases (median: 43 mm; extreme: 1and 160). CRP was elevated in 63.71% of cases (median of 12 mg/l; extreme: 1 and 384). The rheumatoid factor was positive in 57.6% of the cases. The anti-CCP antibodies were present in 89.2% of the cases. Articular erosions were objectified in all cases. A DAS 28 superior to 5

show abstract

“…Certain factors were hypothesized to be involved in the induction and the development of RA; however, the most acceptable theory for the development of the disease is a multifactorial theory that involve the interaction of environmental and genetic background of patients and render them more susceptible to RA [6]. The disease severity is varied from one population to another; African populations, especially Sudanese had more severe form of the disease comparing to other countries [7].…”

Section: Introductionmentioning

confidence: 99%

Association of IL-17A -197G/A (rs2275913) Single Nucleotide Polymorphism and Rheumatoid Arthritis in Sudanese Patients

Osman

Noma

Ahmed³

et al. 2020

Preprint

View full text Add to dashboard Cite

Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. The aim of this study is to determine the association of IL-17A -197G/A polymorphism with RA in Sudanese Patients. A descriptive cross-sectional study was conducted between March and December, 2018. Clinical and demographic data of the study participants were collected and analysed. All statistical tests were considered as statistically significant when p < 0.05.Results: The study population included 266 participants, 166 (63.1%) were females [mean age 41.4 ± 15.5 years] and 97 (36.9%) were males [mean age 36.2 ± 16.0 years]. Of the 266 participants, 31% (85/266) were RA cases and 69% (181/266) were healthy controls. Prevalence of IL-17A genotypes among the study population was 52.6% (140/266) were AG heterozygote genotype, 38.4% (102/266) were AA homozygote genotype, and 9.0% (24/266) were GG homozygote genotype. Correlation of IL-17A genotypes was negatively statistically significant based on participants clinical status, and family history of RA, Pearson’s correlation [r = -0.392, P value 0.001] and [r = -0.226, P value 0.001], respectively, while positively statistically significant with gender, Pearson’s correlation [r = 0.140, P value 0.023]. Based on the duration of RA, no statistically significant correlation was observed, Pearson’s correlation [ r = -0.138, P value 0.207].

show abstract

Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

Cited by 20 publications

References 43 publications

Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis

Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis

Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

Association of IL-17A -197G/A (rs2275913) Single Nucleotide Polymorphism and Rheumatoid Arthritis in Sudanese Patients

Contact Info

Product

Resources

About