Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas

Kai, Keita; Kusano, Koji; Sakai, Masashi; Tabuchi, Masanobu; Yunotani, Seiji; Miyazaki, Kohji; Tokunaga, Osamu

doi:10.1007/s00428-008-0722-6

Cited by 10 publications

(14 citation statements)

References 27 publications

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“…The collagen fibers are swollen eosinophilic and intertwining, while the elastic fibers appear as homogenous, branched or unbranched fibrillar or globular structures, with a distinct linear arrangement [14], and may show a perivascular, pseudo-amyloid arrangement [21]. They react strongly with elastic stains, such as Weigert's, Verhoeff's or Gömöri's methods, and present a central dense core and irregular edges [14].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, they are not myofibroblasts, as is shown by negativity for myogenic markers, such as actins, desmin, calponin, or caldesmon [23][24][25][26][27][28], as well as their ultrastructural features [23]. Tryptase positive mast cells [26] and CD105 positive blood vessels [21] have been implicated in the pathogenesis of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of elastofibroma is debatable, but most evidence suggests a reactive lesion caused by a local mechanical stimulus that induces reactive abnormal elastogenesis by stromal cells [1,21,29] followed by degeneration, appearing first as segmentation of the hyperplastic fibers and then as breaking up of the fibers into globes that are gradually resorbed [22]. Elastotic degeneration of collagen fibers and degeneration of existing elastic fibers do not seem probable [29].…”

Section: Discussionmentioning

confidence: 99%

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Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Tosios

Economou

Vasilopoulos

et al. 2009

Head and Neck Pathol

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Three cases of abnormalities of elastic fibers, two of them on the floor of the mouth and one on the lingual alveolar mucosa, close to the floor of the mouth, in a patient with history of homolateral squamous cell carcinoma of the floor of the mouth, are presented. Comparison with elastofibromatous changes and elastofibromas are made and their possible pathogenesis is discussed. It is suggested that increased awareness may facilitate recognition of such lesions as they can be easily overlooked, especially when they do not present as discrete tumors or they are associated with other ''more significant'' pathologic processes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Tosios

Economou

Vasilopoulos

et al. 2009

Head and Neck Pathol

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“…Elastofibroma is the least common lesion. Table 3 summarizes the clinicopathological features of the previously described 13 cases of this type of lesion [ 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], as well as the present one. The age of the patients ranged from 45 to 88 years (mean, 68.5 years; SD 11.2 years; median, 70.5 years).…”

Section: ⧉ Discussionmentioning

confidence: 94%

Abdominal elastotic lesions. A clinicopathologic study of 23 cases

Val‐Bernal

Mayorga²,

García-Gutierrez³

2021

Rom J Morphol Embryol

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Abdominal elastotic deposits are uncommon lesions that often presents as polyps. They show three histological patterns: fibroelastosis, angioelastosis, and elastofibroma. We describe 23 cases including rare locations, such as mesentery, greater omentum, hernia sac, spleen, peripancreatic fat, and hypodermal fat. The age of the patients ranged from 49 to 93 years (mean, 76.8 years). Most lesions were discovered incidentally in the microscopic study. The most frequent locations were peritoneal subserosa (43.5%) and mesentery/mesocolon/greater omentum (39.1%). The most common pattern was fibroelastosis (69.6%) followed by angioelastosis (26.1%). We observed one case of omental elastofibroma. A review of the 14 abdominal elastofibromas described including our case revealed that the age of the patients ranged from 45 to 88 years (mean, 68.5 years). Female predominance is striking (M:F, 1:12). The most common site was the stomach (50%). The greater omentum (14.3%), small intestine (7.1%), and pancreas (7.1%) are very rare sites for this lesion. Only one case before ours has been published in the greater omentum. The size of the lesions ranged from 0.7 cm to 8 cm (mean 3.2 cm). In 36.4% of the cases located in the digestive tract, the mucosa did not show alterations. Ulcerations (36.4%) or polypoid excrescences (18.2%) were mostly observed. Six (42.9%) cases were asymptomatic and six (42.9%) cases simulated a neoplasm. Two cases were associated with elastofibromas in other locations. Differential diagnosis includes amyloidoma, elastofibrolipoma, mesenteric elastic vascular sclerosis in neuroendocrine tumors, diverticular disease elastosis, pseudoxanthoma elasticum, pulse granuloma, and digestive lesions in patients treated with D-Penicillamine.

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“… 48 , 49 Consistent with our study, it was reported that ED as well as gastrointestinal elastofibroma can develop from perivascular fibrotic lesions containing elastic fibers at various degree of maturation. 50 As far as altered morphology of the elastic fibers in elastofibroma is concerned, its origin is controversial. Some authors suggest that it might be due to genetic predisposition and, 51 in particular, to genomic abnormalities involving genes of elastic fibers metabolism.…”

Section: Discussionmentioning

confidence: 99%

Elastofibroma dorsi: a histochemical and immunohistochemical study

Vito

Scali

Ferraro³

et al. 2015

Eur J Histochem

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Elastofibroma dorsi (ED) is considered a member of a heterogeneous group of benign fibrous (fibroblastic or myofibroblastic) softtissue tumors, frequently localized in the periscapular region in middle aged or older individuals. However, the pathogenesis of ED is still unclear and many authors believe that ED results from a reactive hyperproliferation of fibroblastic tissue, while others suggest that it may be a consequence of a mechanical friction. In our study, we examined 11 cases of ED using histochemical and immunohistochemical methods, in order to extend the knowledge about extracellular matrix composition and histopathogenesis of ED. From the results it appeared that stroma and interspersed spindle cells of ED were positive for both periostin and tenascin-C. Mast cells tryptase-positive were also abundant throughout the lesion. The perivascular distribution of periostin and tenascin-C, associated with the CD34 positivity, suggest that endothelial-mesenchymal transition events can account for neovascularization and production of fibroelastic tissue characteristic of elastofibroma. Our data obtained in endothelial cells cultures demonstrated that elastin production is higher when the status of confluence of the cells is low. So, we can assume that such a phenomenon is a characteristic of mesenchymal/endothelial cells CD34 positive, in which elastin production results to be inversely proportional to the vascular differentiation of cellular elements. In the light of these considerations, we think that a cancerous nature of ED is unlikely. Overall, our study report, for the first time, a detailed description of extracellular matrix composition in ED, suggesting that a mechanical strain-dependent reactivation of periostin and tenascin-C expression, as well as of elastin deposition, could be responsible for development of ED.

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Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas

Cited by 10 publications

References 27 publications

Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Abdominal elastotic lesions. A clinicopathologic study of 23 cases

Elastofibroma dorsi: a histochemical and immunohistochemical study

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