Active MR‐temperature feedback control of dynamic interstitial ultrasound therapy in brain: <i>In vivo</i> experiments and modeling in native and coagulated tissues

N’Djin, W. Apoutou; Burtnyk, Mathieu; Lipsman, Nir; Bronskill, Michael; Kucharczyk, Walter; Schwartz, Michael L.; Chopra, Rajiv

doi:10.1118/1.4892923

Cited by 16 publications

(16 citation statements)

References 96 publications

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“…HIFU ablation requires sequential coagulation of small overlapping volumes with multiple, individual, short-time, high-power sonications that cumulatively can cause treatment to last several hours. 23 Treatment may be limited due to patient motion and near-field heating. 23 Interstitial HIFU technology can provide the means to tailor more conformal heating patterns and allow for precise margins regardless of tumor shape, location, and proximity to blood vessels.…”

Section: Interstitial Hifumentioning

confidence: 99%

“…23 Treatment may be limited due to patient motion and near-field heating. 23 Interstitial HIFU technology can provide the means to tailor more conformal heating patterns and allow for precise margins regardless of tumor shape, location, and proximity to blood vessels. 3 Furthermore, it allows for the possibility of concurrent biopsy, as well as treatment during the same procedure.…”

Section: Interstitial Hifumentioning

confidence: 99%

“…1 In 2014, N’Djin et al conducted a study showing feasibility of spatial heating pattern prediction by using a linear ultrasound transducer in a porcine model. 23 Our lab currently utilizes Acoustic MedSystem, Inc.’s TheraVision Ultrasound Ablation System and ACOUSTx applicators, which contain multiple, cylindrical, MRI-compatible transducers that afford multidirectionality for precise shaping of the ablative field and allow for treatment of large tumors. This is achieved by independently activating the transducers along the length of the applicator.…”

Section: Interstitial Hifumentioning

confidence: 99%

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Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation

MacDonell

Patel

Rubino

et al. 2018

Neurosurgical Focus

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Currently, treatment of brain tumors is limited to resection, chemotherapy, and radiotherapy. Thermal ablation has been recently explored. High-intensity focused ultrasound (HIFU) is being explored as an alternative. Specifically, the authors propose delivering HIFU internally to the tumor with an MRI-guided robotic assistant (MRgRA). The advantage of the authors’ interstitial device over external MRI-guided HIFU (MRgHIFU) is that it allows for conformal, precise ablation and concurrent tissue sampling. The authors describe their workflow for MRgRA HIFU delivery.

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Section: Interstitial Hifumentioning

confidence: 99%

Section: Interstitial Hifumentioning

confidence: 99%

Section: Interstitial Hifumentioning

confidence: 99%

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Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation

MacDonell

Patel

Rubino

et al. 2018

Neurosurgical Focus

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“…Controlled ablation of brain tissue was also demonstrated using multi-faced interstitial applicators in ex vivo experiments [11]. In a recent study aimed at showing initial feasibility, a 6-mm OD rotating endoluminal applicator was interstitially placed within an in vivo porcine brain to perform ablations [43] and evaluate general performance under MR thermometry feedback control, demonstrating a high degree of conformal delivery.…”

Section: Interstitial Cbusmentioning

confidence: 99%

“…MR-guided CBUS consists of MR thermometry with proton resonance shift imaging [36, 111], real-time temperature-based feedback control [43], and post ablation damage assessment through contrast enhanced imaging [10, 37, 43, 111]. In particular, MR temperature imaging (MRTI] which has been a valuable tool in clinical translation of HIFU ablation technology [5, 112] has also found applications in CBUS therapy monitoring.…”

Section: Image Guidancementioning

confidence: 99%

Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

Salgaonkar

Diederich

2015

International Journal of Hyperthermia

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Catheter-based ultrasound (CBUS) is being applied to deliver minimally invasive thermal therapy to solid cancer tumors, benign tissue growth, vascular disease, and tissue remodeling. Compared to other energy modalities used in catheter-based surgical interventions, unique features of ultrasound result in conformable and precise energy delivery with high selectivity, fast treatment times, and larger treatment volumes. Here, a concise review of CBUS technology being currently utilized in animal and clinical studies or being developed for future applications is presented. CBUS devices have been categorized into interstitial, endoluminal and endovascular/cardiac applications. Basic applicator designs, site specific evaluations and possible treatment applications have been discussed in brief. Particular emphasis has been given on ablation studies that incorporate image-guidance for applicator placement, therapy monitoring, feedback control, and post-procedure assessment. Examples of devices included here span the entire spectrum of development cycle from preliminary simulation based design studies to implementation in clinical investigations. The use of CBUS under image guidance has the potential for significantly improving precision and applicability of thermal therapy delivery.

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Detection of Ablation Boundaries Using Different MR Sequences in a Swine Liver Model

Hensen

Drenkmann²,

Frericks

et al. 2022

Cardiovasc Intervent Radiol

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Purpose To determine the magnetic resonance (MR) sequences best suited for the assessment of ablation zones after radiofrequency ablation (RFA). Methods Three percutaneous MR-guided RFA of the liver were performed on three swine. Four pre-contrast and two hepatobiliary post-contrast sequences were obtained after ablation. Tissue samples were extracted and stained for nicotinamide adenine dinucleotide diaphorase hydride (NADH) and with hematoxylin and eosin. Post-ablation MR images and NADH slides were segmented to determine the total ablation zone, their Dice similarity coefficient (DSC), and the contrast-to-noise ratio (CNR) of the visible ablation boundary to normal liver tissue. Results Two distinct layers were combined to determine the ablation zone: an inner layer of coagulation necrosis and an outer layer defined as the peripheral transition zone. Corresponding zones could be found in the MR images as well. Compared to histology, the total area of the MR ablation zone was significantly smaller on the pre-contrast T1 images (p < 0.01) and significantly larger with T2 turbo spin-echo (p = 0.025). No significant difference in size of the ablation zone depiction could be found between histology, post-contrast T1 volumetric interpolated breath-hold examination (VIBE), and post-contrast T1 3D Turboflash (TFL) as well as T2 SPACE images. All sequences but the pre-contrast T1 VIBE sequence showed a DSC above 80% and a high CNR. Conclusions Post-contrast T1 3DTFL performs best when assessing ablation zones after RFA. Since the sequence requires a long acquisition time, T1 VIBE post-contrast offers the best compromise between acquisition time and estimation accuracy.

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Active MR‐temperature feedback control of dynamic interstitial ultrasound therapy in brain: In vivo experiments and modeling in native and coagulated tissues

Abstract: These results support the feasibility of active MRT feedback control of dynamic interstitial ultrasound therapy ofin vivo brain tissues and confirm the feasibility of using simulations to predict spatial heating patterns in the brain.

Cited by 16 publications

References 96 publications

Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation

Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation

Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

Detection of Ablation Boundaries Using Different MR Sequences in a Swine Liver Model

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