Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation

MacDonell, Jacquelyn; Patel, Niravkumar; Rubino, Sebastian; Ghoshal, Goutam; Fischer, Gregory S.; Burdette, Everette C.; Hwang, Roy; Pilitsis, Julie G.

doi:10.3171/2017.11.focus17613

Cited by 53 publications

(46 citation statements)

References 28 publications

(33 reference statements)

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“…Mild hyperthermia or thermal ablation induced by focused ultrasound (FUS) has been widely explored clinically for the treatment of uterine fibroid, 1,2 prostate, 3,4 breast, [5][6][7] and liver 8,9 tumors as well as brain disorder. [10][11][12] In addition, millisecond-long pulses employed in pulsed High-Intensity Focused Ultrasound (p-HIFU) have been demonstrated to be capable of enhancing the delivery of drugs, antibodies, plasmids, or nanoparticles in tumoral tissues [13][14][15][16][17][18] through nonthermal 15,17 and thermal mechanisms. 18 Monitoring temperature during calibration and characterization of the techniques is crucial for ensuring the safety and efficacy of the treatment.…”

mentioning

confidence: 99%

Numerical modeling of ultrasound heating for the correction of viscous heating artifacts in soft tissue temperature measurements

Tiennot

Kamimura

Lee

et al. 2019

Applied Physics Letters

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Measuring temperature during focused ultrasound (FUS) procedures is critical for characterization, calibration, and monitoring to ultimately ensure safety and efficacy. Despite the low cost and the high spatial and temporal resolutions of temperature measurements using thermocouples, the viscous heating (VH) artifact at the thermocouple-tissue interface requires reading corrections for correct thermometric analysis. In this study, a simulation pipeline is proposed to correct the VH artifact arising from temperature measurements using thermocouples in FUS fields. The numerical model consists of simulating a primary source of heating due to ultrasound absorption and a secondary source of heating from viscous forces generated by the thermocouple in the FUS field. Our numerical validation found that up to 90% of the measured temperature rise was due to VH effects. Experimental temperature measurements were performed using thermocouples embedded in fresh chicken breast samples. Temperature corrections were demonstrated for single high-intensity FUS pulses at 3.1 MHz and for multiple pulses (3.1 MHz, 100 Hz, and 500 Hz pulse repetition frequency). The VH accumulated during sonications and produced a temperature increase of 3.1 C and 15.3 C for the single and multiple pulse sequences, respectively. The methodology presented here enables the decoupling of the temperature increase generated by absorption and VH. Thus, more reliable temperature measurements can be extracted from thermocouple measurements by correcting for VH.

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mentioning

confidence: 99%

Numerical modeling of ultrasound heating for the correction of viscous heating artifacts in soft tissue temperature measurements

Tiennot

Kamimura

Lee

et al. 2019

Applied Physics Letters

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“…This possibly obstructs penetration of ultrasonic energy especially in cases of superficial targets or more lateral targets. 97 98 99 …”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future

Jung

Chang

2018

J Korean Med Sci

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Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields. It can generate high-intensity energy at the focal zone in deep body areas without requiring incision of soft tissues. Although the effectiveness of the focused ultrasound technique had not been recognized because of the skull being a main barrier in the transmission of acoustic energy, the development of hemispheric distribution of ultrasound transducer phased arrays has solved this issue and enabled the performance of true transcranial procedures. Advanced imaging technologies such as magnetic resonance thermometry could enhance the safety of MRgFUS. The current clinical applications of MRgFUS in neurosurgery involve stereotactic ablative treatments for patients with essential tremor, Parkinson's disease, obsessive-compulsive disorder, major depressive disorder, or neuropathic pain. Other potential treatment candidates being examined in ongoing clinical trials include brain tumors, Alzheimer's disease, and epilepsy, based on MRgFUS abilities of thermal ablation and opening the blood-brain barrier. With the development of ultrasound technology to overcome the limitations, MRgFUS is gradually expanding the therapeutic field for intractable neurological disorders and serving as a trail for a promising future in noninvasive and safe neurosurgical care.

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“…Such as system can also ablate an epileptogenic zone, as proposed by Curry et al 93,94 Meanwhile, MacDonell et al have proposed a high-intensity focused ultrasound (HIFU) probe in conjunction with a robotic thermal ablation approach. 7 Real-time GPUaccelerated thermal monitoring for thermal ablation therapy of brain tumors has been proposed by Chen, 95 whihc is founded on an efficient computational algorithm, termed the nonlinear distorted Born iterative method (DIBM), for solving the electric volume integral equation.…”

Section: Needle-based Thermal Ablationmentioning

confidence: 99%

“…There is a growing emphasis on both minimally invasive and robotically assisted therapies in neurosurgery. An important class of minimally invasive neurosurgical therapies exploit needle-based delivery mechanisms, which include the positioning of electrodes in deep brain stimulation (DBS) 1 and stereoelectroencephalography (SEEG), 2 intracerebral drug delivery (IDD), 3 stereotactic brain biopsy (SBB), 4 stereotactic needle aspiration for hematoma, cysts and abscesses, 5 and brachytherapy 6 as well as thermal ablation 7,8 of brain tumors and seizure-generating regions. Meanwhile, surgical robotics have also emerged over the past two decades, thereby endowing surgeons with improved precision, stability and control, in a manner that potentiates minimally invasive approaches.…”

Section: Introductionmentioning

confidence: 99%

<p>Robotically Steered Needles: A Survey of Neurosurgical Applications and Technical Innovations</p>

Audette¹,

Bordas²,

Blatt³

2020

RSRR

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This paper surveys both the clinical applications and main technical innovations related to steered needles, with an emphasis on neurosurgery. Technical innovations generally center on curvilinear robots that can adopt a complex path that circumvents critical structures and eloquent brain tissue. These advances include several needle-steering approaches, which consist of tip-based, lengthwise, base motion-driven, and tissue-centered steering strategies. This paper also describes foundational mathematical models for steering, where potential fields, nonholonomic bicycle-like models, spring models, and stochastic approaches are cited. In addition, practical path planning systems are also addressed, where we cite uncertainty modeling in path planning, intraoperative soft tissue shift estimation through imaging scans acquired during the procedure, and simulation-based prediction. Neurosurgical scenarios tend to emphasize straight needles so far, and span deep-brain stimulation (DBS), stereoelectroencephalography (SEEG), intracerebral drug delivery (IDD), stereotactic brain biopsy (SBB), stereotactic needle aspiration for hematoma, cysts and abscesses, and brachytherapy as well as thermal ablation of brain tumors and seizure-generating regions. We emphasize therapeutic considerations and complications that have been documented in conjunction with these applications.

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Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation

Cited by 53 publications

References 28 publications

Numerical modeling of ultrasound heating for the correction of viscous heating artifacts in soft tissue temperature measurements

Numerical modeling of ultrasound heating for the correction of viscous heating artifacts in soft tissue temperature measurements

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future

<p>Robotically Steered Needles: A Survey of Neurosurgical Applications and Technical Innovations</p>

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