Active microparticle manipulation: Recent advances

Cheng, Kunxue; Jie, Guo; Fu, Yusheng; Guo, Jinhong

doi:10.1016/j.sna.2021.112616

Cited by 28 publications

(8 citation statements)

References 164 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A microrobot can be assembled by integrating a microalgal cell ( C. reinhardtii ) and a magnetic microbead by electrostatic interactions. The directional motion is dependent on self‐swimming and magnetophoresis (motion of a particle in a nonuniform magnetic field [ 246 ] ), until magnetophoresis becomes dominant as the microrobot approaches the magnet. [ 247 ] Drug‐loaded polyelectrolyte multilayer (PEM) MPs can be attached to E. coli bacteria by tuning the viscoelastic properties of the bacteria–surface interface ( Figure A).…”

Section: Synthetic Collective Taxesmentioning

confidence: 99%

Collective Behaviors of Active Matter Learning from Natural Taxes Across Scales

Pumera

et al. 2022

Advanced Materials

View full text Add to dashboard Cite

Figure 1. Cognate collective taxis behaviors realized by organisms and robots across scales. A) Collective migration of particle robots and cells. Loosely coupled particles present collective phototaxis (left). Reproduced with permission. [11] Copyright 2019, Springer Nature. Cells perform collective migration in 3D environments (right). Reproduced with permission. [4] Copyright 2018, Springer Nature. B) Self-assembly of robots and bacteria. A swarm of 1024 kilobots form a star-like pattern (left). Reproduced with permission. [14] Copyright 2014, AAAS. A swarm of E. coli cells form a right-handed colony (right). Scale bar: 5 mm. Reproduced with permission. [15] Copyright 2011, The Proceedings of the National Academy of Sciences. C) Collective taxes of macroscopic organisms (e.g., fishes, birds, and ants) and robots. D) Collective taxes of microorganisms (e.g., sperms, [19] cells, and bacteria [20] ) and microrobots. [21] E) Connection constructed by ants and NPs. Weaver ants establish a bridge to connect leaves (left). Reproduced with permission. [7] Copyright 2002, Springer Nature. Magnetic NPs with gold functionalization connect two broken electrodes in a targeted position (right). Reproduced with permission. [16] Copyright 2019, American Chemical Society. F) Avoidance of predators. A bait ball of fishes is formed during the hunting of a sea lion (left). Reproduced with permission. [22] Copyright 2019, Science and Information Organization. The biomimetic predator-prey behavior in a binary system of active micromotors (right). Reproduced with permission. [17] Copyright 2019, American Chemical Society.

show abstract

Section: Synthetic Collective Taxesmentioning

confidence: 99%

Collective Behaviors of Active Matter Learning from Natural Taxes Across Scales

Pumera

et al. 2022

Advanced Materials

View full text Add to dashboard Cite

show abstract

“…Microparticle manipulation has an important role in advancing various facets of biomedical research including sensing, targeted drug delivery, cell analysis, microsurgery, imaging, and diagnostics. − However, effective particle manipulation and trapping in confined spaces and under fluidic flow conditions present a formidable challenge. For instance, in the circulatory systems, high-velocity blood flow rates limit the margination and effective delivery of microparticle-based drug carriers to the target disease area .…”

Section: Introductionmentioning

confidence: 99%

Acoustic Trapping and Manipulation of Hollow Microparticles under Fluid Flow Using a Single-Lens Focused Ultrasound Transducer

Wrede,

Aghakhani,

Bozuyuk

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Microparticle manipulation and trapping play pivotal roles in biotechnology. To achieve effective manipulation within fluidic flow conditions and confined spaces, it is necessary to consider the physical properties of microparticles and the types of trapping forces applied. While acoustic waves have shown potential for manipulating microparticles, the existing setups involve complex actuation mechanisms and unstable microbubbles. Consequently, the need persists for an easily deployable acoustic actuation setup with stable microparticles. Here, we propose the use of hollow borosilicate microparticles possessing a rigid thin shell, which can be efficiently trapped and manipulated using a single-lens focused ultrasound (FUS) transducer under physiologically relevant flow conditions. These hollow microparticles offer stability and advantageous acoustic properties. They can be scaled up and mass-produced, making them suitable for systemic delivery. Our research demonstrates the successful trapping dynamics of FUS within circular tubings of varying diameters, validating the effectiveness of the method under realistic flow rates and ultrasound amplitudes. We also showcase the ability to remove hollow microparticles by steering the FUS transducer against the flow. Furthermore, we present potential biomedical applications, such as active cell tagging and navigation in bifurcated channels as well as ultrasound imaging in mouse cadaver liver tissue.

show abstract

“…2 Among all active methods for manipulating particles/ cells, DEP is one of the most efficient methods, which can precisely separate particles/cells based on their size differences or differences in their electrical properties. [11][12][13] DEP is the motion of a polarized dielectric particle suspended in a medium due to the interaction between the particle and a non-uniform electric field. 14 The particles are attracted to the high electric field regions if the polarizability of the particles is more than that of the medium, called positive DEP (pDEP).…”

Section: Introductionmentioning

confidence: 99%