Active maternal phenotype is established before breeding and leads offspring to align growth trajectory outcomes and reflex ontogeny

Muniz, Gisélia Santana; Beserra, Renata; Silva, Giselle de Paula da; Fragoso, Jéssica; Lira, Allan de Oliveira; Nascimento, Elizabeth do; Castro, Raul Manhães de; Leandro, Carol Góis

doi:10.1016/j.physbeh.2014.02.027

Cited by 11 publications

(12 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rats, a previous study has shown that dams run for <20 min day −1 with a distance travelled not >1 km day −1 during pregnancy and lactation even if they were very active before pregnancy (Santana Muniz et al . ). It was interesting to note that the level of voluntary physical activity was reduced even for dams submitted to a low‐protein diet.…”

Section: Discussionmentioning

confidence: 97%

“…The protocol to classify rats according to their physical activity was described previously (Santana Muniz et al . ).…”

Section: Methodsmentioning

confidence: 97%

“…; Santana Muniz et al . ). In humans, voluntary physical activity is more associated with physical fitness‐related health, reduced stress and body weight gain, and has a strong reward component (Mota et al .…”

Section: Introductionmentioning

confidence: 97%

“…; Santana Muniz et al . ). In our previous study, we provided a comprehensive description of the pattern of maternal voluntary physical activity (30 days before mating), the consequences during pregnancy and lactation for mothers and the effects on earlier time points of neural ontogenesis of offspring (Santana Muniz et al .…”

Section: Introductionmentioning

confidence: 97%

“…In our previous study, we provided a comprehensive description of the pattern of maternal voluntary physical activity (30 days before mating), the consequences during pregnancy and lactation for mothers and the effects on earlier time points of neural ontogenesis of offspring (Santana Muniz et al . ). Although regular maternal physical activity has been shown to promote neuroplasticity in progeny, there is a paucity of studies evaluating its impact in the long term on the development of physical features, reflex ontogeny and locomotor activity of offspring.…”

Section: Introductionmentioning

confidence: 97%

See 4 more Smart Citations

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Fragoso

Lira

Chagas

et al. 2017

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

What is the central question of this study? In the present study, a reproducible model of maternal voluntary physical activity was developed to evaluate the adaptive response of physical activity by attenuating the effects of maternal undernutrition on physical features, reflex ontogeny and growth trajectory of offspring during development. What is the main finding and its importance? Maternal physical activity may induce neuronal maturation of sensorimotor connections impacting on the patterns of locomotor activity in malnourished offspring. Thus, physical activity should be considered as a therapeutic means of countering the effects of maternal undernutrition, by providing a useful strategy for enhancing the neuronal activity of children born to mothers who experience a restricted diet during pregnancy. This study evaluated the effects of maternal voluntary physical activity during pregnancy and lactation on somatic growth (SG), reflex ontogeny (RO) and locomotor activity (LA) of rats whose mothers were protein restricted. Virgin female Wistar rats were divided into the following six groups: control, normal protein (C-NP, n = 4); control, low protein (C-LP, n = 4); inactive, normal protein (I-NP, n = 8); inactive, low protein (I-LP, n = 7); very active, normal protein (VA-NP, n = 8); and very active, low protein (VA-LP, n = 6). Voluntary physical activity was recorded daily in dams. The LP groups were fed an 8% casein diet, whereas control groups were fed a 17% casein diet during pregnancy and lactation. Offspring were evaluated in terms of SG (body weight and length, latero-lateral skull axis and anteroposterior head axis) and RO (palmar grasp, righting, free-fall righting, negative geotaxis, cliff avoidance, auditory startle response and vibrissa placing). The LA was evaluated at 23, 45 and 60 days old in the open field. Voluntary physical activity was reduced during pregnancy and lactation independent of the maternal diet. Pups from LP dams showed delayed SG, reflex maturation and patterns of LA when compared with control pups. The C-LP and I-LP pups showed a delayed SG, RO and LA. Pups from VA-LP mothers showed no delay in SG and RO and presented a faster development of patterns of LA. Maternal voluntary physical activity attenuated the effects of LP diet on indicators of neurodevelopment and patterns of LA of offspring.

show abstract

Section: Discussionmentioning

confidence: 97%

“…The protocol to classify rats according to their physical activity was described previously (Santana Muniz et al . ).…”

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Fragoso

Lira

Chagas

et al. 2017

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

Neonatal kaempferol exposure attenuates gait and strength deficits and prevents altered muscle phenotype in a rat model of cerebral palsy

Visco

Castro

Silva

et al. 2022

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

Cerebral palsy (CP) is characterized by brain damage at a critical period of development of the central nervous system, and, as a result, motor, behavioural and learning deficits are observed in those affected. Flavonoids such as kaempferol have demonstrated potential anti-inflammatory and neuroprotective properties for neurological disorders. This study aimed to assess the effects of neonatal treatment with kaempferol on the body development, grip strength, gait performance and morphological and biochemical phenotype of skeletal muscle in rats subjected to a model of CP. The groups were formed by randomly allocating male Wistar rats after birth to four groups as follows: C = control treated with vehicle, K = control treated with kaempferol, CP = CP treated with vehicle and CPK = CP treated with kaempferol. The model of CP involved perinatal anoxia and sensorimotor restriction of the hind paws during infancy, from the second to the 28th day of postnatal life. Treatment with kaempferol (1 mg/kg) was performed intraperitoneally during the neonatal period. Body weight and length, muscle strength, gait kinetics and Abbreviations: CP, cerebral palsy; LH, left hind paw; PA, perinatal anoxia; p-AKT, phospho-protein kinase B/AKT; p-S6, phospho-ribosomal protein S6; P, postnatal day; RH, right hind paw.

show abstract

Previous adaptation triggers distinct molecular pathways and modulates early and long-term neuroprotective effects of pregnancy swimming preventing neonatal hypoxia-ischemia damage in rats

et al. 2020

View full text Add to dashboard Cite

Active maternal phenotype is established before breeding and leads offspring to align growth trajectory outcomes and reflex ontogeny

Cited by 11 publications

References 44 publications

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Neonatal kaempferol exposure attenuates gait and strength deficits and prevents altered muscle phenotype in a rat model of cerebral palsy

Previous adaptation triggers distinct molecular pathways and modulates early and long-term neuroprotective effects of pregnancy swimming preventing neonatal hypoxia-ischemia damage in rats

Contact Info

Product

Resources

About