Active ingredients fatty acids as antibacterial agent from the brown algae Padina pavonica and Hormophysa triquetra

Shoubaky, Gihan A. El; El, Essam Abd; Salem, Rahman; Madkour, Fedekar F.

doi:10.12980/jclm.2.2014jclm-2014-0025

Cited by 8 publications

(4 citation statements)

References 53 publications

(58 reference statements)

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“…A list of fatty acids and their derivatives comprising dodecanoic acid, tetradecanoic acid, nhexadecanoic acid, hexadecanamide, z-9-octadecenamide and octadecanamide were also detected in this work. They have also been associated with inhibitory actions on microorganisms following their detection from biological extracts that showed microbial inhibitions (El Shoubaky et al, 2014;Karimi et al, 2015;Ma et al, 2014). The above research works also gave credence to this work as the compounds they detected in their work as being responsible for the bacterial inhibition noted were also detected in this work.…”

Section: Discussionsupporting

confidence: 75%

Antibiotic Activity of a Newly Discovered Aspergillus Species Isolated from Sewage Dump Site

M. O.,

C. O.,

C. U.

et al. 2024

African Journal of Biology and Medical Research

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Infectious agents causing diseases are becoming resistant to drugs produced to manage them. This has continued to spur scientific investigations for newer and better antibiotics to aid and/or replace existing ones. Soil samples were collected from sewage dump sites with the sole aim of isolating and screening fungi species for antibacterial substances using the cultural method. A newly discovered fungi species of Aspergillus was used to produce crude antibiotic, fractionated by column chromatography and tested on clinical isolates – Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Candida albicans and Pseudomonas aeruginosa. The result of zones of inhibition was 45 mm, 47 mm, 48 mm, 49 mm and 47 mm in order of listing of organisms. Gas chromatography mass spectrometry analysis of the fractionated extract revealed the following compounds as being responsible for the observed inhibition – methylene chloride, heptanoic acid, octanoic acid, methyl hydrogen phthalate, 2,4-di-tert-butylphenol, dodecanoic acid, z-10-tetradecen-1-ol acetate, tetradecanoic acid, 2-tetradecyloxy-ethanol, n-hexadecanoic acid, hexadecanamide, octadecenamide and octadecanamide. A cocktail of organic compounds – fatty acids and amides that displayed strong antimicrobial ability, if well tapped, hold a future in the development of new antibiotics.

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Section: Discussionsupporting

confidence: 75%

Antibiotic Activity of a Newly Discovered Aspergillus Species Isolated from Sewage Dump Site

M. O.,

C. O.,

C. U.

et al. 2024

African Journal of Biology and Medical Research

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“…The major fatty acids were margaric, palmitic, and oleic acids accounting for 39.55, 29.84, and 6.49% of the fatty acid composition, respectively. El Shoubaky and El Rahman Salem [ 36 ] identified palmitic acid (28.10%) and oleic acid (19.80%) as major fatty acids in the fatty acid composition of P. pavonica .…”

Section: Resultsmentioning

confidence: 99%

Seasonal Changes in Chemical Profile and Antioxidant Activity of Padina pavonica Extracts and Their Application in the Development of Bioactive Chitosan/PLA Bilayer Film

Čagalj

Zemljič

Glaser

et al. 2022

Foods

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Seaweeds are a potentially sustainable source of natural antioxidants that can be used in the food industry and possibly for the development of new sustainable packaging materials with the ability to extend the shelf-life of foods and reduce oxidation. With this in mind, the seasonal variations in the chemical composition and antioxidant activity of brown seaweed (Padina pavonica) extracts were investigated. The highest total phenolic content (TPC) and antioxidant activity (measured by ferric reducing/antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, and oxygen radical absorbance capacity (ORAC)) were found for P. pavonica June extract. The TPC of 26.69 ± 1.86 mg gallic acid equivalent/g, FRAP of 352.82 ± 15.41 µmole Trolox equivalent (TE)/L, DPPH of 52.51 ± 2.81% inhibition, and ORAC of 76.45 ± 1.47 µmole TE/L were detected. Therefore, this extract was chosen for the development of bioactive PLA bilayer film, along with chitosan. Primary or quaternary chitosan was used as the first layer on polylactic acid (PLA) films. A suspension of chitosan particles with entrapped P. pavonica extract was used as the second layer. X-ray photoelectron spectroscopy confirmed the presence of layers on the material surface. The highest recorded antioxidant activity of the newly developed films was 63.82% inhibition. The developed functional films exhibited antifogging and antioxidant properties, showing the potential for application in the food industry.

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“…On the other hand, n-hexadecanoic acid had been linked to antibiosis before now (El-Shoubaky et al, 2014;Kairmi et al, 2015). Not only have that Again oleic acid has also been linked to antibiosis in the past against E. coli, Salmonella typhimurium, P. aeruginosa and Bacillus cereus using cocktail fatty acids according to the works of Sultan et al (2009) and Rasha (2019).…”

Section: Discussionmentioning

confidence: 99%

The Production of Medically Important Bioactive Compounds by a Newly Discovered Fungi Species (Purpureocillium Species) - PP537396

M. O.,

C. O.,

C. U.

et al. 2024

African Journal of Biology and Medical Research

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The clog in the wheel of progress in management of infectious diseases has necessitated a continuous search for suitable bioactive agents for desired relief. Thus this work was to specifically screen previously isolated, newly discovered fungi species for bioactive agents. The fungi species – Purpureocillium sp was used to produce a crude antibiotic substance, extracted with acetone and tested on clinical isolates – Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Candida albicans. The result of zones of inhibition was 20mm, 15mm, 16mm, 0mm and 20mm in order of listing of the organisms. The result of GC-MS test pin-points these compounds – t-9-octadecenoic acid, oleic acid, hexadecanoic acid methyl ester, z-9-octadecenamide, hexadecanoic acid and methylene chloride as been responsible for observed inhibition. The fungus was also used to produce a crude amylase and tested it on clinical organisms as above with no antibiotic activity. The enzyme activity of the crude enzyme was 70U/L. The antibiotic product holds a promise for a desired drug for mixed microbial infection just like the enzyme which can be coupled to a nano silver particle for drug delivery.

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Active ingredients fatty acids as antibacterial agent from the brown algae Padina pavonica and Hormophysa triquetra

Cited by 8 publications

References 53 publications

Antibiotic Activity of a Newly Discovered Aspergillus Species Isolated from Sewage Dump Site

Antibiotic Activity of a Newly Discovered Aspergillus Species Isolated from Sewage Dump Site

Seasonal Changes in Chemical Profile and Antioxidant Activity of Padina pavonica Extracts and Their Application in the Development of Bioactive Chitosan/PLA Bilayer Film

The Production of Medically Important Bioactive Compounds by a Newly Discovered Fungi Species (Purpureocillium Species) - PP537396

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