Active biomaterials for mechanobiology

Özkale, Berna; Sakar, Mahmut Selman; Mooney, David J.

doi:10.1016/j.biomaterials.2020.120497

Cited by 68 publications

(55 citation statements)

References 178 publications

(159 reference statements)

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“…Mechanomedicine has been defined as the art of mechanobiology-based medicine ( Wang, 2017 ). Thus, it may be applied to pathological conditions for which mechanobiology is either paramount for organ and tissue functions (e.g., cardiovascular, reproductive and respiratory systems), or maybe used to study and possibly target diseased tissues and cells, as it is the case in cancer ( Ma et al, 2016 ; Özkale et al, 2021 ). Cancer mechanomedicine is illustrated for instance by research on modifying tumor vasculature to improve drug efficacy.…”

Section: A Bright Future For 3d Cell Culture In Mechanomedicinementioning

confidence: 99%

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

Chhetri

Rispoli

Lelièvre

2021

Front. Mol. Biosci.

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The discovery that the stiffness of the tumor microenvironment (TME) changes during cancer progression motivated the development of cell culture involving extracellular mechanostimuli, with the intent of identifying mechanotransduction mechanisms that influence cell phenotypes. Collagen I is a main extracellular matrix (ECM) component used to study mechanotransduction in three-dimensional (3D) cell culture. There are also models with interstitial fluid stress that have been mostly focusing on the migration of invasive cells. We argue that a major step for the culture of tumors is to integrate increased ECM stiffness and fluid movement characteristic of the TME. Mechanotransduction is based on the principles of tensegrity and dynamic reciprocity, which requires measuring not only biochemical changes, but also physical changes in cytoplasmic and nuclear compartments. Most techniques available for cellular rheology were developed for a 2D, flat cell culture world, hence hampering studies requiring proper cellular architecture that, itself, depends on 3D tissue organization. New and adapted measuring techniques for 3D cell culture will be worthwhile to study the apparent increase in physical plasticity of cancer cells with disease progression. Finally, evidence of the physical heterogeneity of the TME, in terms of ECM composition and stiffness and of fluid flow, calls for the investigation of its impact on the cellular heterogeneity proposed to control tumor phenotypes. Reproducing, measuring and controlling TME heterogeneity should stimulate collaborative efforts between biologists and engineers. Studying cancers in well-tuned 3D cell culture platforms is paramount to bring mechanomedicine into the realm of oncology.

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Section: A Bright Future For 3d Cell Culture In Mechanomedicinementioning

confidence: 99%

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

Chhetri

Rispoli

Lelièvre

2021

Front. Mol. Biosci.

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“…This research area will further optimize the biomechanical parameters of tissue-engineered implants and better understand cell- and drug-based therapeutic effects on mechanical behaviour at the tissue-level. In regard to tissue engineering, current biomaterial-related hot topics are “smarter” materials that are both degradable and able to control, steer or modulate biological responses and processes [ 72 , 73 ]. The role of extracellular matrix in instructing biochemical cascades in cells has become rather evident [ 74 , 75 ].…”

Section: Introductionmentioning

confidence: 99%

The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?

et al. 2021

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Orthopaedic and trauma research is a gateway to better health and mobility, reflecting the ever-increasing and complex burden of musculoskeletal diseases and injuries in Germany, Europe and worldwide. Basic science in orthopaedics and traumatology addresses the complete organism down to the molecule among an entire life of musculoskeletal mobility. Reflecting the complex and intertwined underlying mechanisms, cooperative research in this field has discovered important mechanisms on the molecular, cellular and organ levels, which subsequently led to innovative diagnostic and therapeutic strategies that reduced individual suffering as well as the burden on the society. However, research efforts are considerably threatened by economical pressures on clinicians and scientists, growing obstacles for urgently needed translational animal research, and insufficient funding. Although sophisticated science is feasible and realized in ever more individual research groups, a main goal of the multidisciplinary members of the Basic Science Section of the German Society for Orthopaedics and Trauma Surgery is to generate overarching structures and networks to answer to the growing clinical needs. The future of basic science in orthopaedics and traumatology can only be managed by an even more intensified exchange between basic scientists and clinicians while fuelling enthusiasm of talented junior scientists and clinicians. Prioritized future projects will master a broad range of opportunities from artificial intelligence, gene- and nano-technologies to large-scale, multi-centre clinical studies. Like Prometheus in the ancient Greek myth, transferring the elucidating knowledge from basic science to the real (clinical) world will reduce the individual suffering from orthopaedic diseases and trauma as well as their socio-economic impact.

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“…Such biomaterials can be programmed to exert dynamic mechanical forces on cells and tissues in a controllable manner, thereby mimicking the native tissue microenvironment. These biomaterials thus have a capacity to pattern physiological processes, including tissue morphogenesis and regeneration ( Özkale et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Creating a Pro-Regenerative Tissue Microenvironment: Local Control is the Key

Lumelsky

2021

Front. Bioeng. Biotechnol.

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Active biomaterials for mechanobiology

Cited by 68 publications

References 178 publications

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?

Creating a Pro-Regenerative Tissue Microenvironment: Local Control is the Key

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