Creating a Pro-Regenerative Tissue Microenvironment: Local Control is the Key

Lumelsky, Nadya

doi:10.3389/fbioe.2021.712685

Cited by 8 publications

(11 citation statements)

References 54 publications

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“…The choice of scaffold materials and design impacts the therapeutic potential and the number and invasiveness of associated clinical procedures [12]. As scaffolds may change their physical and chemical properties and transfer mechanical forces in vivo in response to various internal and external stimuli, they may contribute both to regeneration and to the development of a reaction to a foreign body and fibrosis [11]. This necessitates the complete understanding of cell-scaffold interactions.…”

Section: Extracellular Matrixmentioning

confidence: 99%

“…It is noteworthy that the successful penetration of cells and their presence in the scaffold is regulated by biomaterials' surface features and cell-matrix interactions of cells with biomaterial [28,29]. Thus, the scaffold constructions designed by tissue engineering can ensure a suitable microenvironment for resident SCs' homing and the controlled release of biological signals, including matrix-associated growth factors (fibroblast growth factor (FGF), TGF-β, bone morpho-genetic protein (BMP)) [30,31], which aid with model physiological processes, including tissue morphogenesis and regeneration [11].…”

Section: Extracellular Matrixmentioning

confidence: 99%

“…Additionally, external tensile, compressive and shear forces have a massive effect on the phenotype of cells, the properties of the ECM, and the general functions of the niche. In turn, cells in tissues affect their microenvironment by internal mechanical forces-adhesion interactions of their cytoskeleton with the ECM and adjacent cells via the niche [11]. Thus, the interaction and optimization of every niche component involved in ERM is especially important for understanding how the required cell response should be made safe and efficient for therapy [12].…”

Section: Introductionmentioning

confidence: 99%

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Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Иванов

Кузнецова

Попова

et al. 2021

IJMS

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An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration.

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Section: Extracellular Matrixmentioning

confidence: 99%

Section: Extracellular Matrixmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Иванов

Кузнецова

Попова

et al. 2021

IJMS

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“…In the long term, efforts aim to promote the well-being of patients in need of transplants or to restore damaged and/or diseased organs and tissues (Petrosyan et al, 2022). To achieve this, it is essential to amalgamate knowledge from cellular therapy, tissue engineering, and organ regeneration with available technologies such as nanotechnology and 3D bio-printing (Galliot et al, 2017;Lumelsky, 2021). Consequently, innovative techniques and promising biomaterials for use in human regeneration gain prominence, such as the use of genomic editing tools in conjunction with stem cell studies (Häneke, 2022), as well as genetic editing techniques like CRISPR-Cas (De Sio, Imperador, 2023), and the development of lithium-doped bioactive ceramics (Easterling, Engbrecht, Crespi, 2019) or the utilization of marine collagen for bone regeneration (Farmani et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Advances in Biotechnology for Cellular and Tissue Regeneration: Challenges and Perspectives in Human Disease Treatment

Pavan,

Giacinti,

Alvarenga

et al. 2024

RECIMA21

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Biotechnology constitutes a realm of inquiry that extends its benefits across diverse domains of knowledge, ranging from agricultural sciences to clinical applications. This field leverages technology to address challenges frequently entailing living organisms. Of current significance is the endeavor to elucidate the process of animal regeneration, particularly within the human species, given its burgeoning potential as an ally in the treatment and cure of various maladies. Recognizing the societal importance of this subject, the present article seeks to expound upon contemporary biotechnological advancements facilitating the exploration of cellular and tissue regeneration for the treatment of human diseases. To this end, a comprehensive review of articles delineating the current landscape was conducted, involving a comparative analysis of regenerative activity across species, with a specific focus on humans. Evidentially, the use of biomaterials in tissue regeneration assumes paramount importance, albeit not without the formidable challenge posed by the inflammatory process. Stem cells, conversely, present themselves as promising entities in the realm of regeneration. However, their interaction within the host organism necessitates further scrutiny to attain a more nuanced understanding. Despite strides made in the field of regenerative medicine, the lack of comprehensive comprehension regarding the properties of biomaterials and their responses within the human body constrains their clinical applicability. Nevertheless, an auspicious future is envisioned, marked by advancements in biomaterials and a heightened understanding of interactions within the human body, thereby fostering the development of more efficacious treatments for a myriad of diseases.

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“…The effects of tissue regeneration rest with mesenchymal stem cells and their microenvironment, just as plants’ growth depends on their healthy seeds and fertile soil ( Figure 1 ) [ 26 , 27 , 28 ]. Dental stem cells are a large class of commonly used seed cells with the ability of cell proliferation and multi-differentiation, such as dental pulp stem cells (DPSCs), stem cells from the apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), which have the potential to differentiating dental pulp [ 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Creating a Microenvironment to Give Wings to Dental Pulp Regeneration—Bioactive Scaffolds

Jiang

et al. 2023

Pharmaceutics

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Dental pulp and periapical diseases make patients suffer from acute pain and economic loss. Although root canal therapies, as demonstrated through evidence-based medicine, can relieve symptoms and are commonly employed by dentists, it is still difficult to fully restore a dental pulp’s nutrition, sensory, and immune-regulation functions. In recent years, researchers have made significant progress in tissue engineering to regenerate dental pulp in a desired microenvironment. With breakthroughs in regenerative medicine and material science, bioactive scaffolds play a pivotal role in creating a suitable microenvironment for cell survival, proliferation, and differentiation, following dental restoration and regeneration. This article focuses on current challenges and novel perspectives about bioactive scaffolds in creating a microenvironment to promote dental pulp regeneration. We hope our readers will gain a deeper understanding and new inspiration of dental pulp regeneration through our summary.

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Creating a Pro-Regenerative Tissue Microenvironment: Local Control is the Key

Cited by 8 publications

References 54 publications

Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Advances in Biotechnology for Cellular and Tissue Regeneration: Challenges and Perspectives in Human Disease Treatment

Creating a Microenvironment to Give Wings to Dental Pulp Regeneration—Bioactive Scaffolds

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