Active adenosine transporter-mediated adenosine entrance into HL-60 cells leads to the induction of apoptosis through down-regulation of c-Myc

Hong, S H; Jeong, Seong‐Yun; Ahn, Sang‐Gun; Hwang, In-Sung; Kim, In-Kyung

doi:10.1038/emm.1997.28

Cited by 10 publications

(1 citation statement)

References 32 publications

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“…The alteration of c-myc was shown to be involved in the apoptosis of HL-60 cells (Kimura et al, 1995) and U-937 cells (Bergan et al, 1996) and the expression of c-myc was diminished during adenosine-induced apoptosis in HL-60 cells (Hong et al, 1997). Possible relationships with the c-myc expression with DZA-induced apoptosis in both human leukemia HL-60 and U-937 cells were explored.…”

Section: C-myc and Puf Are Down-regulated During Dzainduced Apoptosismentioning

confidence: 99%

Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

Kim

Jeong²,

Lee³

et al. 2000

Exp Mol Med

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Section: C-myc and Puf Are Down-regulated During Dzainduced Apoptosismentioning

confidence: 99%

Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

Kim

Jeong²,

Lee³

et al. 2000

Exp Mol Med

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Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata

Park

Hong²,

Moon³

et al. 2004

Cancer Letters

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Heat shock proteins and their role in early mammalian development

Walsh

Mj²,

Smith³

1997

Exp Mol Med

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A b s t r a c tElevated body temperature can result from many agents in the natural environment, such as fever, hot weather and heavy exercise. In our modern living conditions additional sources of induced hyperthermia including hot baths, saunas, drugs, electromagnetic radiation and ultrasound have been introduced. Hyperthermia during pregnancy has been shown to cause a wide spectrun of effects in all species studied, including humans, the outcome depending on the dose of heat absorbed by the mother and embryo and the stage of enbryonic or fetal development when exposed. The dose of heat is the product of the elevation of temperature above normal and the duration of the elevation. In relatively uncontrolled natural environmental exposures, embryonic death and resorption or abortion are probably the most common outcome. In less severe exposures (smaller doses) major or minor developmental defects can result and the central nervous system appears to be a major target for its effects. Heat damage to embryos appears to be by apoptotic and other forms of cell death in organs at critical stages of development. Over many millennia all living orgaisms appear to have developed protective m e c h a n i s m s against excess heat, known collectively as the heat shock response. This response has been s t u d i e d intensively over the last 20 years and its mechanisms of protection are now becoming more clearly defined. Exposures to heat (and a number of other toxic agents) trigger the heat shock response which is characterized by abrupt suspension in the normal protein synthesis and the concurrent induction of heat shock genes (hsp) and the synthesis of a set of protein families known collectively as the heat shock proteins (HSP). The hsp are known to be involved in the response in embryos, each has at least two copies, one which appears to have functions in the normal embryonic development (cognate) and another which is induced at a certain dose of heat (induced) and which can offer some protection against damage for some time after the initiating dose.

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Active adenosine transporter-mediated adenosine entrance into HL-60 cells leads to the induction of apoptosis through down-regulation of c-Myc

Abstract: A b s t r a c tAlthough

Cited by 10 publications

References 32 publications

Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata

Heat shock proteins and their role in early mammalian development

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