Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata

Park, Soo Young; Hong, Yun–Chul; Moon, Ji Young; Lee, Nam Ho; Kim, Se Jae; Kang, Ji Hoon; Lee, Young Ki; Park, Deok Bae; Yoo, Eun Sook; Kang, Hee Kyoung

doi:10.1016/j.canlet.2003.09.034

Cited by 15 publications

(7 citation statements)

References 28 publications

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“…Eurya emarginata (Thumb) Makino (Theaceae) is distributed in coastal areas from southern China, along southern Korea and extending to central and southern Japan (Chung & Epperson 2000). The leaves of E. emarginata exhibit anticancer activities (Park et al 2004(Park et al , 2005a. Moreover, eutigoside C (Figure 1), a new compound isolated from E. emarginata, is reported to be responsible for the anti-inflammatory activity of the leaves (Park et al 2005b).…”

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confidence: 99%

Eutigoside C inhibits the production of inflammatory mediators (NO, PGE2, IL-6) by down-regulating NF-κB and MAP kinase activity in LPS-stimulated RAW 264.7 cells

Lee¹,

Oh²,

Yoon³

et al. 2008

Journal of Pharmacy and Pharmacology

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Eutigoside C, a compound isolated from the leaves of Eurya emarginata, is thought to be an active anti-inflammatory compound which operates through an unknown mechanism. In the present study we investigated the molecular mechanisms of eutigoside C activity in lipopolysacchardide (LPS)-stimulated murine macrophage RAW 264.7 cells. Treatment with eutigoside C inhibited LPSstimulated production of nitric oxide (NO), prostaglandin E 2 (PGE 2 ) and interleukin-6 (IL-6). To further elucidate the mechanism of this inhibitory effect of eutigoside C, we studied LPS-induced nuclear factor (NF)-kB activation and mitogen-activated protein (MAP) kinase phosphorylation. Eutigoside C suppressed NF-kB DNA binding activity, interfering with nuclear translocation of NF-kB. Eutigoside C suppressed the phosphorylation of three MAP kinases (ERK1/2, JNK and p38). These results suggest that eutigoside C inhibits the production of inflammatory mediators (NO, PGE 2 and interleukin-6) by suppressing the activation and translocation of NF-kB and the phosphorylation of MAP kinases (ERK1/2, JNK and p38) in LPS-stimulated murine macrophage RAW 264.7 cells.

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confidence: 99%

Eutigoside C inhibits the production of inflammatory mediators (NO, PGE2, IL-6) by down-regulating NF-κB and MAP kinase activity in LPS-stimulated RAW 264.7 cells

Lee¹,

Oh²,

Yoon³

et al. 2008

Journal of Pharmacy and Pharmacology

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“…On the other hand, this treatment presents downregulation of Bcl-2 and upregulation of Bax mRNA expression, which suggest a differential activity through Bax/Bcl-2 pathways by BNDC. In normal cells, Bcl-XL preferentially associates with Bak, while Bcl-2 associate with Bax to trigger apoptosis, being a differential action in Bax/Blc-2 pathway a good strategy to develop new anticancer drugs against cancer cells with Bcl-XL overexpression (Willis et al, 2005;Park et al, 2004;Liu et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Discovery of cytotoxic and pro-apoptotic compounds against leukemia cells: Tert-butyl-4-[(3-nitrophenoxy) methyl]-2,2-dimethyloxazolidine-3-carboxylate

et al. 2011

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Section: Introductionmentioning

confidence: 99%

“…Eurya japonica (EJ) is an ornamental plant distributed in coastal areas, particularly in southern Korea, southern China and south central Japan ( 14 , 15 ). The leaves of Eurya emarginata have been used to treat ulcers or as a diuretic in certain regions of Asia ( 14 ). Recent studies have suggested that EJ has a variety of biological functions, including anti-cytotoxic, anti-apoptotic, anti-angiogenic and anti-cancer effects ( 14 , 16-19 ).…”

Section: Introductionmentioning

confidence: 99%

“…The leaves of Eurya emarginata have been used to treat ulcers or as a diuretic in certain regions of Asia ( 14 ). Recent studies have suggested that EJ has a variety of biological functions, including anti-cytotoxic, anti-apoptotic, anti-angiogenic and anti-cancer effects ( 14 , 16-19 ). Furthermore, chrysoeriol, eutigoside B and eutigoside C isolated from EJ leaves were revealed to exert anti-oxidative and anti-inflammatory effects ( 19-21 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Eurya japonica extracts on human corneal epithelial cells and experimental dry eye

Jin

et al. 2020

Exp Ther Med

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Eurya japonica (EJ) leaves have been indicated to exert anti-oxidative and anti-inflammatory effects. Dry eye disease (DED) is a chronic inflammatory disease and oxidative stress is closely associated with DED. The aim of the present study was to analyze the therapeutic efficacy of EJ in DED using human corneal epithelial (HCE) cells and a mouse model of experimental dry eye (EDE). EJ extracts (0.001, 0.01 and 0.1%) were used to treat HCE cells. Cell viability and mitochondrial function were detected using a EZ-Cytox cell viability assay kit and mitochondrial membrane potential assays. Dichlorofluorescein diacetate (DCF-DA) assay was used to measure cellular reactive oxygen species (ROS) levels. Subsequently, eye drops consisting of BSS or 0.001%, 0.01 and 0.1% EJ extracts were applied for treatment of EDE. At 7 days, conjunctival ROS production was measured using a DCF-DA assay. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, 10 kDa interferon gamma-induced protein 10 (IP-10) and monokine induced by interferon-γ (MIG) levels in the conjunctiva were analyzed using a multiplex immunobead assay. Tear film and ocular surface parameters were measured. Treatment with EJ extracts in HCE cells effectively improved cell viability, ROS levels and mitochondrial function. Mice treated with 0.01 and 0.1% EJ extracts indicated a significant decrease in ROS, TNF-α, IL-1β, IP-10 and MIG levels compared with the EDE or BSS groups. Furthermore, a significant improvement in all clinical parameters was observed in the 0.01 and 0.1% EJ extract groups. EJ extracts could decrease cytotoxicity and ROS production in HCE cells. Additionally, topical EJ extracts reduced oxidative damage and inflammation and improved clinical signs of EDE, suggesting that EJ extracts may be used as an adjunctive therapy for DED.

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Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata

Cited by 15 publications

References 28 publications

Eutigoside C inhibits the production of inflammatory mediators (NO, PGE2, IL-6) by down-regulating NF-κB and MAP kinase activity in LPS-stimulated RAW 264.7 cells

Eutigoside C inhibits the production of inflammatory mediators (NO, PGE2, IL-6) by down-regulating NF-κB and MAP kinase activity in LPS-stimulated RAW 264.7 cells

Discovery of cytotoxic and pro-apoptotic compounds against leukemia cells: Tert-butyl-4-[(3-nitrophenoxy) methyl]-2,2-dimethyloxazolidine-3-carboxylate

Effects of Eurya japonica extracts on human corneal epithelial cells and experimental dry eye

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