Activation of β‐Chemokines and CCR5 in Persons Infected with Human Immunodeficiency Virus Type 1 and Tuberculosis

Mayanja‐Kizza, Harriet; Wajja, Anne; Wu, Mianda; Peters, Pierre; Nalugwa, Gladys; Mubiru, Francis; Aung, Htin; Vanham, Guido; Hirsch, Christina S.; Whalen, Christopher D.; Ellner, Jerrold J.; Toossi, Zahra

doi:10.1086/320724

Cited by 28 publications

(16 citation statements)

References 14 publications

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Section: New Rounds Of Hiv-1 Infection During Tbmentioning

confidence: 99%

“…Of interest, the induction of HIV-1 inhibitory b chemokines macrophage inflammatory protein (MIP)-1a and RANTES by MTB was limited in HIV-1-infected patients who were coinfected with TB, compared with those not coinfected with TB [8]. On the other hand, the expression of CCR5 mRNA was higher in patients coinfected with HIV-1/TB than in patients with TB but not HIV-1, and higher amounts of CCR5 were found on the CD4 T cells in PBMCs of patients coinfected with HIV-1/TB [8]. The increase in HIV-1 activity in the pleural compartment of patients coinfected with HIV-1/TB was found in association with the enhanced expression of CCR5 mRNA by pleural mononuclear cells and low levels of the HIV-1-inhibiting b chemokines RANTES and MIP-1a in situ [32].…”

Section: New Rounds Of Hiv-1 Infection During Tbmentioning

confidence: 99%

“…Of interest, in a recent prospective study of patients with HIV-1/TB coinfection, TB was found to exert its most significant effect on lowering survival rates in subjects with more preserved immunological status (i.e., CD4 cell counts 1200 cells/mL) [10]. Of note, at least 50% of TB cases in HIV-1-infected subjects occur in those with CD4 cell counts 1200 cells/mL [8]. Therefore, the possible impact of TB on HIV-1 disease is substantial.…”

mentioning

confidence: 99%

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Virological and Immunological Impact of Tuberculosis on Human Immunodeficiency Virus Type 1 Disease

Toossi¹

2003

J INFECT DIS

Self Cite

142

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Unlike other opportunistic infections associated with human immunodeficiency virus (HIV) type 1, tuberculosis (TB) occurs throughout the course of HIV-1 infection, and, as a chronic infection, its impact on viral activity is sustained. In dually infected subjects, HIV-1 load and heterogeneity are increased both locally and systemically during active TB. Studies over the past decade have indicated that Mycobacterium tuberculosis (MTB) infection supports HIV-1 replication and dissemination through the dysregulation of host cytokines, chemokines, and their receptors. Furthermore, concentrations of HIV-1 inhibitory chemokines are limited during TB and at sites of MTB infection. Cumulatively, these data indicate that TB provides a milieu of continuous cellular activation and irregularities in cytokine and chemokine circuits that are permissive of viral replication and expansion in situ. I address new research that has identified the basis for the augmentation of HIV-1 replication during TB and discuss potential immunotherapies to contain viral expansion during TB.

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Section: New Rounds Of Hiv-1 Infection During Tbmentioning

confidence: 99%

Section: New Rounds Of Hiv-1 Infection During Tbmentioning

confidence: 99%

mentioning

confidence: 99%

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Virological and Immunological Impact of Tuberculosis on Human Immunodeficiency Virus Type 1 Disease

Toossi¹

2003

J INFECT DIS

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142

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“…In pregnant women with HIVPlasmodium falciparum co-infection, an increased expression of CCR5 on macrophages has been found [7]. Mayanja-Kizza et al [8] also reported an up-regulation of CCR5 on peripheral blood mononuclear cells of HIV-positive patients co-infected with Mycobacterium tuberculosis. On the contrary, a downregulation of CCR5 expression on T cells has been shown in HIV-HGV co-infected individuals, who seem to have a slower progression towards AIDS [9].…”

Section: Discussionmentioning

confidence: 92%

CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects

Nigro

Rizzo

Vancheri

et al. 2007

Med Microbiol Immunol

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CC chemokine receptor 5 (CCR5) and CC chemokine receptor 3 (CCR3) are membrane-bound proteins involved in HIV-1 entry into susceptible cells. All T lymphocyte subsets display CCR5 and CCR3 on their membrane surface. T helper 1 cells are known to express CCR5 but not CCR3, and most of T cells expressing CCR3 are T helper 2. This study aimed to assess the expression of CCR5 and CCR3 on peripheral blood CD3+ T lymphocytes of HIV-Leishmania co-infected individuals. A total of 36 subjects were enrolled; nine had HIV-Leishmania co-infection; nine were HIV-infected without Leishmania, nine had visceral leishmaniasis without HIV co-infection and nine were healthy blood donors. HIV-Leishmania co-infected subjects showed a significantly higher rate of CCR5+CD3+ T lymphocytes in comparison with the other studied groups. The higher rate of CD3+ T-cells expressing CCR5 found in HIV-Leishmania co-infected subjects may be related to the role of Leishmania as an enhancer of the progression to AIDS.

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“…Oft handelt es sich bei Patienten in frühen Stadien (> 500 CD4+ T-Lymphozyten/ìl) der Erkrankung um Reaktivierungen latenter MTB-Infektionen, wäh-rend Patienten mit fortgeschrittener Immundefizienz häufig Anzeichen einer progressiven postprimären Tuberkulose aufweisen [58]. Bei diesen Patienten ist die Formation von Granulomen durch den Verlust von CD4+ T-Lymphozyten gering [59] und es treten häufig miliare Streuungen durch hämatogene und lymphatische Aussaat der Bakterien auf [60].…”

Section: Tb: Einfluss Auf Die Hiv-infektionunclassified

HIV und Lunge

Lange

Schaaf²,

Dalhoff³

2004

Pneumologie

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HIV-infection is characterized by a progressive immunodeficiency that predisposes affected persons to opportunistic infections and neoplasias. Pulmonary co-infections play a key role in HIV-infection as the airways are constantly exposed to aerosolized microorganisms during ventilation. In addition to the spectrum of microorganisms that are responsible for the development of community acquired pneumonia in immunocompetent hosts, persons with HIV-infection are vulnerable to infections with organisms that profit from the progressive cellular immune defects. Examples are infections with Pneumocystis jirovecii, non-tuberculous mycobacteria and viral pathogens. In contrast, tuberculosis can occur in all stages of HIV-infection. Following the HIV-pandemic, the incidence of tuberculosis has increased again in many areas of the world. The advent of antiretroviral therapies (ART) in recent years had resulted in a dramatic decrease of HIV-related morbidity and mortality in industrialized countries. As a result of the reconstitution of the immune-system under ARTs the incidence of pulmonary co-infections has also declined substantially in persons living with HIV in countries where these therapies are available.

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Activation of β‐Chemokines and CCR5 in Persons Infected with Human Immunodeficiency Virus Type 1 and Tuberculosis

Cited by 28 publications

References 14 publications

Virological and Immunological Impact of Tuberculosis on Human Immunodeficiency Virus Type 1 Disease

Virological and Immunological Impact of Tuberculosis on Human Immunodeficiency Virus Type 1 Disease

CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects

HIV und Lunge

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