Activation of vascular smooth muscle of rat aorta by noradrenaline and depolarization: Two different mechanisms

Peiper, U.; Griebel, L.; Wende, W.

doi:10.1007/bf00588736

Cited by 117 publications

(58 citation statements)

References 37 publications

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“…Calcium antagonists such as verapamil were also reported to block voltage-operated calcium channels much more effectively than receptor operated calcium channels (14,15). However, in rat uterus, we could not detect essential differences between the effect of e-CgTX on the contractile response to ACh and that to high KCI, although we observed that the enhancing effect of w-CgTX on the con tractile responses to high KCI (in various concentrations) tended to be much greater than that on the response to ACh (Figs.…”

Section: Resultsmentioning

confidence: 99%

Effects of Synthetic ω-Conotoxin on the Contractile Responses of Segments of Rat Ileum, Stomach Fundus and Uterus and Guinea Pig Taenia Coli

Ichida

Oka

Masada

et al. 1988

Japanese Journal of Pharmacology

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Abstract-The effect of synthetic w-conotoxin (w-CgTX) on the contractile re sponses of segments of rat ileum, stomach fundus and uterus and guinea pig taenia coli were investigated. w-CgTX (10-9-5 X 10-6 M) did not inhibit the contractile responses of al! smooth muscle segments to high KCI and/or ACh. However, unexpectedly, w-CgTX (3x10-7-10-5 M) alone caused dose-dependent con traction of segments of the stomach fundus and uterus. These contractile responses to w-CgTX alone depended upon the presence and/or the influx of extracellular Cat+; and they were inhibited by calcium antagonists such as diltiazem, nitrendipine and verapamil, with the exception that the segments of stomach fundus was not inhibited by verapamil. With the segments of uterus, but not those of other tissues, w-CgTX (10-7-5X10-6 M) significantly enhanced the contractile responses to various concentrations of ACh and high KCI. With rat ileum and guinea pig taenia coli segments, w-CgTX (10-9-5x10-6 M) did not induce a contractile response or have an enhancing effect. These findings suggest that w-CgTX may have a calcium agonist-like effect on smooth muscles such as the stomach fundus and uterus of rats.

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Section: Resultsmentioning

confidence: 99%

Effects of Synthetic ω-Conotoxin on the Contractile Responses of Segments of Rat Ileum, Stomach Fundus and Uterus and Guinea Pig Taenia Coli

Ichida

Oka

Masada

et al. 1988

Japanese Journal of Pharmacology

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“…The inhibitory action of papaverine on contractions evoked by different stimulants is nonspecific in vascular smooth muscle (20)(21)(22).…”

Section: Discussionmentioning

confidence: 98%

“…Propantheline bromide exerted a relaxing action on Ball responses at high concentrations, consistent with the observation of Fredericks et al (19) who found that this drug is an effective relaxant of the Ball response on rabbit detrusor. The relative effectiveness against con tractile responses of vascular smooth muscle to different stimulants excludes papaverine, a PDE inhibitor, from the group of specific Ca antagonists such as D-600, verapamil and nifedipine (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Smooth muscle relaxing drugs and guinea pig ileum.

et al. 1981

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Abstract-The effects of various smooth muscle relaxing drugs on con tractile responses to acetylcholine (ACh), Ba2+ and Ca", and on the tissue cyclic AMP levels were examined in the guinea pig ileum. Papaverine and theophylline caused a decrease both in the maximum height and the slope of dose-response curves induced by the three stimulants, and an increase in the cyclic AMP levels.Diltiazem and D-600 produced a decrease in the maximum and the slope of ACh and Ba2+ dose-response curves, shifted the Ca" dose-response curves to higher concentrations, in a parallel manner, but failed to change the cyclic AMP levels. Etomidoline and benactyzine shifted the curves for the three stimulants in parallel to the right, but at higher concentrations depressed the maximum of ACh and Ba2+ responses with a further parallel shift. These drugs exerted little influence on the basal level of tissue cyclic AMP, but etomidoline signifi cantly depressed the Bat+-induced increase in cyclic AMP level. The smooth muscle relaxing drugs used could be classified in three types, thereby suggesting that there are at least three different mechanisms involved in smooth muscle relaxing action.

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“…In the present experiments, the contractile response of the pulmonary vessel was completely inhibited by papaverine, but not verapamil (Tables 2 and 3). Peiper et al (15) indicated the mechanisms by which the contraction of the vascular smooth muscle was induced.…”

Section: Papaverinementioning

confidence: 99%

The Effects of Tetrodotoxin, Papaverine and Verapamil on the Increase in the Rate of Spontaneous Afferent Discharges Induced by Local Anesthetics from the Pulmonary Mechanoreceptors of the Bullfrog

Kontani

Koshiura

1985

Japanese Journal of Pharmacology

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Abstract-Procaine(1 X 10-5-1 X 10-4 M), dibucaine (1 X 10-5-1 X 10-4 M) and tetracaine (1 X 10-6-1 X 10-5 M) caused an increase followed by a decrease in the rate of spontaneous afferent (A) discharges (D) accompanied with a decrease in the flow rate of perfusion solution from the pulmonary vein in the isolated lung of the bullfrog, but these local anesthetics only decreased the rate of A.D. synchronized with lung inflation. The stimulatory effects of these drugs on the rate of spon taneous A.D. were studied.In the presence of TTX (1 X 10-7 M), the increase in the rate of spontaneous A.D. by local anesthetics was inhibited, but the decrease in the flow rate of perfusion solution by these drugs was not inhibited. Papaverine (1 X10-5 M), which inhibited the decrease in the flow rate of perfusion solution by these local anesthetics, inhibited the increase in the rate of spontaneous A.D. by dibucaine, but not those by procaine and tetracaine.The inhibitory effects on the increase in the rate of spontaneous A.D. by these local anesthetics could be seen with verapamil in a concentration(1 X10-4 M) which significantly inhibited the rate of spontaneous A.D., like TTX (1 X10-7 M). Verapamil could not reverse the decrease in the flow rate of perfusion solution by these local anesthetics.From these results, the increase in the rate of spontaneous A.D. by procaine and tetracaine is due to not only the contractile effects of the drugs on the pulmonary vessel but also the direct stimulatory effects on the receptors which generate spontaneous A.D., and the increase in the rate of spontaneous A.D. by dibucaine may result from the contraction of the pulmonary vessel, and the stimulatory effect of dibucaine on the receptors would be weaker than that of procaine and tetracaine, since dibucaine could cause the increase in the rate of spontaneous A.D. only when dibucaine decreased the flow rate of perfusion solution.

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Activation of vascular smooth muscle of rat aorta by noradrenaline and depolarization: Two different mechanisms

Cited by 117 publications

References 37 publications

Effects of Synthetic ω-Conotoxin on the Contractile Responses of Segments of Rat Ileum, Stomach Fundus and Uterus and Guinea Pig Taenia Coli

Effects of Synthetic ω-Conotoxin on the Contractile Responses of Segments of Rat Ileum, Stomach Fundus and Uterus and Guinea Pig Taenia Coli

Smooth muscle relaxing drugs and guinea pig ileum.

The Effects of Tetrodotoxin, Papaverine and Verapamil on the Increase in the Rate of Spontaneous Afferent Discharges Induced by Local Anesthetics from the Pulmonary Mechanoreceptors of the Bullfrog

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