Activation of nuclear factor kappa B and induction of migration inhibitory factor in tumors by surgical stress of laparotomy versus carbon dioxide pneumoperitoneum: an animal experiment

Abstract

After CO(2) pneumoperitoneum, tumors have less TNFalpha and MIF expression and less NFkappaB activity than after laparotomy. This may be associated with less tumor growth, supporting minimal invasive techniques in gastrointestinal oncologic surgery.

A Prospective Case-Control Study of the Local and Systemic Cytokine Response After Laparoscopic Versus Open Colonic Surgery

“…In addition, local peritoneal cytokines also have a specific role to play in postoperative ileus [22][23][24][25][26], the formation of peritoneal adhesions [27][28][29][30][31][32], and tumor promotion [33][34][35][36][37]. Only two studies identified in the meta-analysis above measured levels of local peritoneal humoral factors, and their results were conflicting.…”

Syndecan‐1 modulates β‐integrin‐dependent and interleukin‐6‐dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation

“…Furthermore, the downstream effector of IL-6, NF-jB [45], is activated by the engagement of a 5 b 1 -integrin [57]. IL-6 is considered to be an inducer of this critical regulator of cancer cell invasiveness [58][59][60], and activated NF-jB synergizes with IL-6 gene transcription in a positive feedback loop [45]. Sdc-1 depletion apparently leads to deregulation of this process in MDA-MB-231 cells, consistent with a role for syndecan glycosaminoglycan chainmediated binding of cytokines and their receptors in a coreceptor function for proinflammatory signaling [2,7].…”

Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model

“…Recently, using the same model, we have reported for the first time, to our knowledge, that the surgical impact of laparotomy and CO 2 pneumoperitoneum could enhance the activity of nuclear factor kappa B (NFjB) and the mRNA expression of migration inhibitory factor (MIF) and TNFa in human gastric cancer [25]. Also, this previous study shows the possibility that the tumor growth could be affected not only by the extent of surgical stress but also by the location and the size of tumor.…”