Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model

Amin, Anwar Tawfik; Shiraishi, Norio; Ninomiya, Shigeo; Tajima, Masaaki; Ito, Masafumi; Kitano, Seigo

doi:10.1007/s00464-009-0793-8

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…disease and incision-wounding modeled in our study. Interestingly, a recent animal study reported that expression of survivin in residual tumor tissues, taken as a surrogate marker of chemoresistance, began increasing within 6 h of surgery, peaked at post-operative day 2, and decreased to baseline levels by post-operative day 7 [ 29 ]. This suggested chemoresistance pattern during the immediate post-operative period is consistent with our finding of impaired cisplatin activity perioperatively vs. 7 days later.…”

Section: Discussionmentioning

confidence: 99%

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

et al. 2018

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BackgroundPrimary cytoreductive surgery followed by adjuvant chemotherapy is the standard treatment for advanced epithelial ovarian cancer. The average interval between surgery and chemotherapy initiation is approximately 4-weeks at most centers; however, since surgery may accelerate residual tumor growth, a shorter interval may be more beneficial.MethodsThe murine ID8 cell model of ovarian cancer was used to examine the efficacy of cisplatin treatment administered perioperatively or 7 days after surgical wounding. Luciferase-expressing cells ID8 cells were injected intraperitoneally (i.p.) into female C57/Bl6 mice. Fourteen days post-injection, animals received an abdominal incision or anesthesia alone and received i.p. cisplatin either on the surgical day or 7 days later, or received no chemotherapy. Additional animals received cisplatin 28 days after wounding for comparison.ResultsAbdominal tumor mass increased 2.5-fold in wounded vs. unwounded animals as determined by bioluminescent in vivo tumor imaging. Cisplatin administered on the day of wounding decreased tumor burden by 50%, as compared to 90% in unwounded animals. Cisplatin on day 7 or day 28 decreased tumor burden by 80 and 37% respectively.ConclusionsSurgical wounding increases ovarian tumor mass and decreases perioperative cisplatin efficacy in this animal model. Administration of cisplatin 1 week after surgery was more effective than cisplatin administered perioperatively or 4 weeks after surgery.Electronic supplementary materialThe online version of this article (10.1186/s13048-018-0428-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

et al. 2018

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“…A previous study used BALB/c mice to conduct the laparotomy and revealed an increase in the PI3K/ AKT-dependent tumor growth (Coffey, Wang, Bouchier-Hayes, Cotter, & Redmond, 2006). Meanwhile, increased expressions of EGFR and HER2 were reported to be involved in the enhanced tumor growth and chemoresistance induced by surgical stress from a laparotomy (Amin et al, 2010). In the current study, our results provided direct evidence to support that laparotomy promotes tumor progression in CT26 cells with the differentiation of tumor volumes in the laparotomy group and the control group.…”

Section: Discussionmentioning

confidence: 99%

Surgical trauma‐induced CCL18 promotes recruitment of regulatory T cells and colon cancer progression

Sun

et al. 2018

Journal Cellular Physiology

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“…In addition to the above five newly identified genes, we analyzed histamine receptor H1 (HRH1) since a previous study reported that this gene was overexpressed in gastric cancer cells, and the expression of this gene satisfied the above criteria (21). Moreover, three candidate marker genes [keratin 20 (CK20), epidermal growth factor receptor (EGFR) and carcinoembryonic antigen (CEA)], which have been reported to be promising markers for the detection of cancer cells, were further analyzed (11,13,22,23).…”

Section: Identification Of Up-or Down-regulated Genes In the Gastricmentioning

confidence: 99%

Identification of novel molecular markers for detection of gastric cancer cells in the peripheral blood circulation using genome-wide microarray analysis

Matsumura

Zembutsu

Yamaguchi

et al. 2011

Experimental and Therapeutic Medicine

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Abstract.Although metastasis or relapse is a leading cause of death for patients with gastric cancer, the hematogenous spread of cancer cells remains undetected at the time of initial therapy. The development of novel diagnostic molecular marker(s) to detect circulating gastric cancer cells is an issue of great clinical importance. We obtained peripheral blood samples from 10 patients with gastric cancer who underwent laparotomy and 4 healthy volunteers. Microarray analysis consisting of 30,000 genes or ESTs was carried out using eight gastric cancer tissues and normal gastric mucosae. We selected 53 genes up-regulated in gastric cancer compared to normal gastric mucosae from our microarray data set, and, among these, identified five candidate marker genes (TSPAN8, EPCAM, MMP12, MMP7 and REG3A) which were not expressed in peripheral blood mononuclear cells (PBMCs) from 4 healthy volunteers. We further carried out semi-quantitative nested reverse transcription-polymerase chain reaction (RT-PCR) for HRH1, EGFR, CK20 and CEA in addition to the five newly identified genes using PBMCs of patients with gastric cancer, and found that expression of one or more genes out of the nine was detected in 80% of the patients with gastric cancer. Moreover, the numbers of genes expressed in PBMCs were ≤2 and ≥2 in all vascular invasion-negative cases and in 5 of 6 positive cases, respectively, showing significant differences between the two groups (P=0.041). Nested RT-PCR analysis for the set of nine marker genes using PBMCs may provide the potential for detection of circulating gastric cancer cells prior to metastasis formation in other organs.

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Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model

Cited by 8 publications

References 33 publications

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

Surgical trauma‐induced CCL18 promotes recruitment of regulatory T cells and colon cancer progression

Identification of novel molecular markers for detection of gastric cancer cells in the peripheral blood circulation using genome-wide microarray analysis

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