Activation of Notch signaling in human tongue carcinoma

Abstract

Expressions of Notch receptors and ligands in tongue carcinoma and adjacent non-neoplastic tongue tissues suggest that Notch signaling may control cell differentiation and proliferation of carcinoma cells. The disorder of Notch signaling may be a mechanism of the tongue carcinoma development.

The pathological significance of Notch1 in oral squamous cell carcinoma

“…In previous studies, the overexpression of Notch1 and its ligands has been observed in OSCC specimens. 34,35 However, a recent study demonstrated opposite results to this study. The study of Sakamoto et al 24 showed similar Notch1 expression to that observed in our study in normal tissues, whereas their results for dysplastic and cancerous tissues were different, and Notch1 was downregulated in the neoplastic lesions.Although the antibodies against Notch1 and staining method used in our study were different from those used by Sakamoto et al, 24 our immunohistochemical staining results showed clear and specific membranous staining.…”

Expression of EGFR, VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma

“…Of particular interest is NOTCH1, the second most commonly mutated gene in HNSCC after p53 [22,23]. NOTCH1 is over-expressed in HNSCC relative to normal tissue [21,[24][25][26][27]. Evidence for the role of NOTCH1 in angiogenesis is preliminary, and to our knowledge no studies have made direct comparison between NOTCH1 and VEGF or EGFR.…”

Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma

“…7,26 It has recently been demonstrated that Notch1 mutations are frequently found in HNSCC, suggesting a potential role for this pathway in the biology of CSCs and in the etiology of head and neck cancer. 13 Zhang et al 27 reported high expression levels of Notch receptors and ligands in tongue cancer and suggested that Notch signaling may control the differentiation and proliferation of tongue carcinoma cells. Zeng et al 10 reported that HNSCC may utilize the Notch signaling pathway to promote tumor angiogenesis in vivo, and that the level of Jagged1 expression is associated with the development of 9 reported that Notch1 expression is associated with cisplatin resistance in HNSCC.…”