The pathological significance of Notch1 in oral squamous cell carcinoma

Yoshida, Ryoji; Nagata, Masashi; Nakayama, Hideki; Niimori-Kita, Kanako; Hassan, Wael Abdo; Tanaka, Takuji; Shinohara, Masanori; Ito, Takaaki

doi:10.1038/labinvest.2013.95

Cited by 96 publications

(87 citation statements)

References 49 publications

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“…The results showed that Notch signaling inhibition resulted in the decrease of OSCC cell proliferation. Correspondingly, previous studies demonstrated that DAPT treatment inhibited cell proliferation in various cancer cell types, including hepatocellular carcinoma, glioma, lung adenocarcinoma, and OSCC (55)(56)(57)(58). Several mechanisms have been examined, including apoptosis induction, cell cycle arrest, and cancer cell cytotoxicity.…”

Section: Discussionmentioning

confidence: 98%

Expression and influence of Notch signaling in oral squamous cell carcinoma

2016

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Section: Discussionmentioning

confidence: 98%

Expression and influence of Notch signaling in oral squamous cell carcinoma

2016

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“…This concept may need to be further validated with the studies targeting SCCs from other tissues, such as lung and cervical whose molecular pathogenesis remains poorly understood. However, the oncogenic role of Notch in HNSCC is likely, as the increased levels of Notch signaling components in OSCC/ESCC were reported 82, 84, 85, although their biological consequences remain to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased NOTCH1 was associated with the inhibition of cell proliferation in the OSCC cell line 84. Blocking Notch activation by gamma‐secretase inhibitor can suppress OSCC growth in vitro 83 and inhibit the growth of human tongue carcinoma cell line 86.…”

Section: Notch Signaling In Head and Neck Squamous Cell Carcinoma (Hnmentioning

confidence: 96%

“…The main concern is regarding the elevated levels of Notch signaling pathway genes in different HNSCC/ESCC. Notch signaling pathway components (including Notch receptors, ligands, or targets genes such as HES1 , HEY1 , or HEY2 ) were found to be amplified or overexpressed in a subset of tongue tumor samples 80, in HNSCC tumors over normal mucosa 81, in OSCC 82, 83, 84, and frequently in ESCC samples 85.…”

Section: Notch Signaling In Head and Neck Squamous Cell Carcinoma (Hnmentioning

confidence: 99%

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Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

et al. 2016

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The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro‐oncogenic, typically depending on the cellular context. Squamous cell carcinoma (SCC) is a cancer of the squamous cell, which can occur in diverse human tissues. SCCs are one of the most frequent human malignancies for which the pathologic mechanisms remain elusive. Recent genomic analysis of diverse SCCs identified marked levels of mutations in NOTCH1, implicating Notch signaling pathways in the pathogenesis of SCCs. In this review, evidences highlighting NOTCH's role in different types of SCCs are summarized. Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers. Finally, we discuss the convergent view on an intriguing possibility that Notch may function as tumor suppressor in SCCs across different tissues. These mechanistic insights into Notch signaling pathways will help to guide the research of SCCs and development of therapeutic strategies for these cancers.

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“…However, this model has been challenged by evidence that HNSCCs display a bimodal pattern of Notch alterations, including a subset of tumors with increased expression of ligands JAG1 and JAG2, as well as the NOTCH1 and NOTCH3 receptors (14)(15)(16)(17)(18). In addition, in vitro work has shown a relationship between Notch1 activity and clinically relevant characteristics, such as cancer stem cell-like properties and TNFa-mediated inflammation (15,16,18).…”

Section: Introductionmentioning

confidence: 99%