1975
DOI: 10.1016/0022-2836(75)90238-7
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Activation of myosin synthesis in fusing and mononucleated myoblasts

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Cited by 197 publications
(44 citation statements)
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“…However, they concluded that the development of these enzyme activities in both M3A and L6 cells was dependent on cell density and not on fusion. Somite myoblasts synthesize myosin prior to fusion (43), and in other experiments one or more characteristics of fused muscle was detected in single myoblasts in which fusion was reversibly inhibited by Ca2+ deprivation (7,9) or treatment with phospholipase C (35 …”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…However, they concluded that the development of these enzyme activities in both M3A and L6 cells was dependent on cell density and not on fusion. Somite myoblasts synthesize myosin prior to fusion (43), and in other experiments one or more characteristics of fused muscle was detected in single myoblasts in which fusion was reversibly inhibited by Ca2+ deprivation (7,9) or treatment with phospholipase C (35 …”
Section: Discussionmentioning
confidence: 97%
“…Fusion into myotubes usually takes place after withdrawal of the myoblasts from the cell cycle (7,14,15), perhaps as the 'result of the expression or activation of new information during the immediately preceding round of replication (2,14). Cells that fuse to form myotubes have depleted levels of DNA polymerase and cease replication (16,17).…”
mentioning
confidence: 99%
“…Calcium ion is required for myoblast fusion (49); cultures treated with a low-calcium medium (49) or with the Ca §247 EGTA (37), do not fuse. There have been several recent reports that fusion can be selectively blocked by calcium depletion from the medium without any apparent inhibition of the synthesis of several major components that mark the course of muscle differentiation, i.e., the appearance of muscle proteins such as the acetylcholine receptor (36), acetylcholinesterase, and adenylate cyclase (41), contractile proteins (16,19,34,57), creatine phosphokinase activity (31,55,56,62) and the elevation of cAMP levels (62). (b) BUdR treatment.…”
Section: Discussionmentioning
confidence: 99%
“…However, previous studies have shown that myoblast fusion and expression of muscle-specific genes can be uncoupled by the use of inhibitors (10,12,22) or as a result of mutations (1,23). Therefore, we looked for musclespecific gene expression in tdM5i-QECs by staining cells with antibodies to muscle-specific proteins.…”
Section: Skv-qecsmentioning
confidence: 99%