Activation of leukocyte immunoglobulin-like receptor B2 signaling pathway in cortical lesions of pediatric patients with focal cortical dysplasia type IIb and tuberous sclerosis complex

Yue, Jiong; Zhang, Chunqing; Shi, Xianjun; Wei, Yujia; Liu, Shiyong; Yang, Hui

doi:10.1016/j.braindev.2019.08.002

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…The protein levels of FGF13 in the TSC samples were positively correlated with the frequency of seizures, whereas the protein levels of LILRB2 were negatively correlated with the frequency of seizures in TSC patients before surgery. 50,51 GPR30 expression was significantly decreased in the epileptogenic tubers of female patients with TSC and could be a potential protective effect in the epileptogenesis of female patients with TSC. 52 Activation of Nogo-A via the NgR/LINGO-1/TROY and interleukin 6 signal transduction pathways, and upregulated transient receptor potential vanilloid 4 (TRPV4), TPRV1 MMP9 and transient receptor potential channels may be involved in seizure activity and DRE in TSC.…”

Section: Resective Surgerymentioning

confidence: 93%

“…The epileptogenic mechanism was studied based on the tubers removed. The protein levels of FGF13 in the TSC samples were positively correlated with the frequency of seizures, whereas the protein levels of LILRB2 were negatively correlated with the frequency of seizures in TSC patients before surgery 50,51 . GPR30 expression was significantly decreased in the epileptogenic tubers of female patients with TSC and could be a potential protective effect in the epileptogenesis of female patients with TSC 52 .…”

Section: Surgical Treatmentmentioning

confidence: 95%

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Progress of clinical research studies on tuberous sclerosis complex‐related epilepsy in China

Liu

Chen

Zhai

et al. 2022

Acta Neuro Scandinavica

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Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome, with 75.6%–83.5% and 54.1% patients presenting with epilepsy and drug‐resistant epilepsy (DRE), respectively. Clinical studies on TSC, particularly surgical interventions, have achieved rapid and substantial progress. The TSC‐Task Force Committee of the China Association Against Epilepsy (CAAE‐TFTSC) was founded in 2012, and annual academic conferences on the surgical treatment of TSC‐related epilepsy have been held since 2013. ‘China experts' consensus on surgical treatment of TSC‐related epilepsy’ was published in 2019. This review focuses on surgical treatment, including resective surgery, neuromodulations, corpus callosotomy and mini‐invasive ablations, as well as studies on phenotype, genotype and anti‐seizure therapies of mammalian target of rapamycin inhibitor, vigabatrin and ketogenic diet in patients with TSC‐related DRE in China.

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Section: Resective Surgerymentioning

confidence: 93%

Section: Surgical Treatmentmentioning

confidence: 95%

Progress of clinical research studies on tuberous sclerosis complex‐related epilepsy in China

Liu

Chen

Zhai

et al. 2022

Acta Neuro Scandinavica

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Importance of GWAS in finding un-targeted genetic association of sporadic Alzheimer’s disease

Bagaria

Nho

2021

Mol. Cell. Toxicol.

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Balloon cells in malformations of cortical development: friends or foes?

Liu,

Shen,

Lin

et al. 2024

Acta Epileptologica

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Balloon cells (BCs) are specific pathological marker of cortical malformations during brain development, often associated with epilepsy and development delay. Although a large number of studies have investigated the role of BCs in these diseases, the specific function of BCs as either epileptogenic or antiepileptic remains controversial. Therefore, we reviewed literatures on BCs, delved into the molecular mechanisms and signaling pathways, and updated their profile in several aspects. Firstly, BCs are heterogeneous and some of them show progenitor/stem cell characteristics. Secondly, BCs are relatively silent in electrophysiology but not completely isolated from their surroundings. Notably, abnormal mTOR signaling and aberrant immunogenic process have been observed within BCs-containing malformations of cortical development (MCDs). The question whether BCs function as the evildoer or the defender in BCs-containing MCDs is further discussed. Importantly, this review provides perspectives on future investigations of the potential role of BCs in epilepsy.

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Activation of leukocyte immunoglobulin-like receptor B2 signaling pathway in cortical lesions of pediatric patients with focal cortical dysplasia type IIb and tuberous sclerosis complex

Cited by 3 publications

References 29 publications

Progress of clinical research studies on tuberous sclerosis complex‐related epilepsy in China

Progress of clinical research studies on tuberous sclerosis complex‐related epilepsy in China

Importance of GWAS in finding un-targeted genetic association of sporadic Alzheimer’s disease

Balloon cells in malformations of cortical development: friends or foes?

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