Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity

Mantovani, Alberto; Polentarutti, Nadia; Alessandri, Giulio; Vecchi, Annunciata; Giuliani, F; Spreafico, F.

doi:10.1038/bjc.1977.214

Cited by 8 publications

(1 citation statement)

References 20 publications

(18 reference statements)

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“…The mFS6 sarcoma is weakly immunogenic, 60 and 75 % of mice immunized by surgical excision of the tumor rejecting challenge with lo4 and l o 3 tumor cells respectively (Mantovani, 1978). The macrophage contents of the 3LL, M5, M 109 and mFS6 tumors are 2, 2, 3 and 19% respectively (Mantovani et a/., 1977b;Mantovani, 1978;and unpublished data).…”

Section: Tumorsmentioning

confidence: 70%

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

Mantovani

Giavazzi

Polentarutti

et al. 1980

Intl Journal of Cancer

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The effects of silica and carrageenan on primary tumor growth and metastases were evaluated in c57bl/6 and BALB/c mice transplanted with the poorly immunogenic Lewis lung (3ll) carcinoma, mFS6 sarcoma and Madison 109 carcinoma spontaneously metastasizing to the lungs. Silica and carrageenan significantly enhanced lung metastases and decreased primary tumor weight in all three experimental models. A similar augmentation of lung secondaries was found after i.v. inoculation of 3LL tumor cells. The effects of carrageenan on primary 3LL tumor growth and metastases were observed also in thymus-deprived animals. The effect of macrophage toxins was studied also in C57BL/6 mice transplanted with the M5076/73A ovarian carcinoma. This tumor spontaneously metastasizes to various abdominal organs, but not to the lung. After treatment with carrageenan, lung metastases were observed, but no effect on secondaries at other anatomical sites or on the primary tumor was detectable. It is suggested that host defense mechanisms impaired by silica and carrageenan may have divergent effects in the regulation of growth of some primary tumors and spontaneous lung metastases.

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Section: Tumorsmentioning

confidence: 70%

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

Mantovani

Giavazzi

Polentarutti

et al. 1980

Intl Journal of Cancer

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Antibody-dependent cell-mediated cytotoxicity in human cancer: Characterization of patient leukocyte activity and treatment effects

Hersh

Murphy

Gutterman

et al. 1982

Cancer

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Antibody-dependent cell-mediated cytotoxicity (ADCC), medicated by peripheral blood Hypaque-Ficoll separated mononuclear cells, was studied in humans using chicken erythrocytes (CRBC) incubated in a 1:1200 dilution of rabbit anti-CRBC and human B erythrocytes (HRBC) incubation in a 1:20 dilution of isoantibody. At the optimal target effector ratio of 3:1, ADCC to both CRBC and HRBC was significantly higher than normal in 27 lung cancer, 18 malignant melanoma, and seven colon cancer patients, but not in 20 breast cancer patients. Chemotherapy (single-agent or combination) in 12 patients did not effect ADCC in vitro but significantly suppressed ADCC to both targets after only four or five days of therapy in vivo (ADCC to CRBC, 47.4 to 24.1% lysis: ADCC to HRBC, 48.1 to 16.3% lysis). Immunotherapy with intravenous (IV) corynebacterium parvum or IV methanol extraction residue of BCG (MER) boosted ADCC to both targets within four to seven days of the first dose. It was found that ADCC to HRBC but not to CRBC was completely absent in three cases of active hairy cell leukemia but was present in two cases in remission. The ADCC to HRBC showed an age-dependent increase in both the 51 normal subject and the cancer patients. This was not observed for ADCC to CRBC. The ADCC to CRBC was mediated mainly by an Fc-receptor-positive, nonadherent, small lymphocyte, and ADCC to HRBC was mediated entirely by an adherent monocyte. The ADCC did not correlate significantly with the H3 thymidine incorporation of peripheral blood mononuclear cells, cultured without stimulation for either one or seven days. It also did not correlate with the number of residual granulocytes in the mononuclear cell suspensions. Measurement of ADCC is a useful method of characterizing host defense in malignant disease and its modification by therapy.

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Restraint Stress Reduces the Antitumor Efficacy of Cyclophosphamide in Tumor-Bearing Mice

Zorzet

Perissin

Rapozzi

et al. 1998

Brain, Behavior, and Immunity

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Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity

Cited by 8 publications

References 20 publications

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

Antibody-dependent cell-mediated cytotoxicity in human cancer: Characterization of patient leukocyte activity and treatment effects

Restraint Stress Reduces the Antitumor Efficacy of Cyclophosphamide in Tumor-Bearing Mice

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