Activation of estrogen receptor-β by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds

Effect of long-term piceatannol treatment on eNOS levels in cultured endothelial cells

“…It has also been reported that activation of estrogen receptors is associated with the up-regulation of eNOS expression by resveratrol. Both piceatannol and resveratrol act as estrogen receptor agonists [39,40], and estrogen receptor activation is associated with the up-regulation of eNOS protein levels [41]. Even in the present study, piceatannol activation of estrogen receptors may be associated with the up-regulation of eNOS expression.…”

Polyphenolic composition of roots and petioles of Rheum rhaponticum L.

“…According to recent investigations, the main active components in this extract are hydroxystilbenes Wober et al, 2007).…”

Activation of transgenic estrogen receptor-beta by selected phytoestrogens in a stably transduced rat serotonergic cell line

“…We observed high levels of transgenic ER␤ mRNA and protein levels in RNDA cells using quantitative real-time PCR and PAGE electrophoresis followed by Western blotting. Moreover, the proof of functionality and specificity of estrogen receptor action was carried out using a reporter gene assay utilizing a plasmid containing an ERE-luciferase construct, as has been described for other cell lines by our group and collaborators [37,38]. Subsequently, we tested the estrogen-like bioactivity of GEN, DAI and EQ in addition to NAR, 8-PN, 6-DMAN and 7-O-PN utilizing the same reporter gene assay.…”