Polyphenolic composition of roots and petioles of <i>Rheum rhaponticum </i>L.

Püssa, Tõnu; Raudsepp, Piret; Kuzina, Kristina; Raal, Ain

doi:10.1002/pca.1102

Cited by 44 publications

(37 citation statements)

References 25 publications

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“…Few reports have even shown that aloe leaf extract can itself exert some carcinogenic activity (Ahlawat & Khatkar, 2011;Boudreau et al, 2013). Aloin and aloe emodin were found in roots and petioles of Rheum rhaponticum L. (Polygonaceae) (dietary rhubarb) cultivated in Estonia, but not mentioned in folk medicine as the anticancer herbal remedy (Püssa et al, 2009).…”

Section: Herbsmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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Context: Despite diagnostic and therapeutic advancements, the burden of cancer is still increasing worldwide. Toxicity of current chemotherapeutics to normal cells and their resistance to tumor cells highlights the urgent need for new drugs with minimal adverse side effects. The use of natural anticancer agents has entered into the area of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants. Objective: To lead the search for plants with potential cytotoxic activity, ethnopharmacological knowledge can give a great contribution. Therefore, the attention of this review is devoted to the natural remedies traditionally used for the cancer treatment by Estonian people over a period of almost 150 years. Methods: Two massive databases, the first one stored in the Estonian Folklore Archives and the second one in the electronic database HERBA (http://herba.folklore.ee/), containing altogether more than 30 000 ethnomedicinal texts were systematically reviewed to compile data about the Estonian folk traditional experiences on natural anticancer remedies.

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Section: Herbsmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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“…However, in this species, resveratrol and another likely intermediate, resveratrol-3-Oglucoside, appear in high concentrations in the rhizome (Pü ssa et al, 2009). In contrast, in both wild-type P. abies as well as transgenic lines overexpressing the PaSTS1 resveratrol synthase, only minute amounts of resveratrol and its 3-O-glucoside were detected.…”

Section: Stilbene Biosynthesis In Spruce Is a Defense Mechanism Againmentioning

confidence: 99%

Biosynthesis of the Major Tetrahydroxystilbenes in Spruce, Astringin and Isorhapontin, Proceeds via Resveratrol and Is Enhanced by Fungal Infection

et al. 2011

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V6T 1Z4 (S.G.R., J.B.)Stilbenes are dibenzyl polyphenolic compounds produced in several unrelated plant families that appear to protect against various biotic and abiotic stresses. Stilbene biosynthesis has been well described in economically important plants, such as grape (Vitis vinifera), peanut (Arachis hypogaea), and pine (Pinus species). However, very little is known about the biosynthesis and ecological role of stilbenes in spruce (Picea), an important gymnosperm tree genus in temperate and boreal forests. To investigate the biosynthesis of stilbenes in spruce, we identified two similar stilbene synthase (STS) genes in Norway spruce (Picea abies), PaSTS1 and PaSTS2, which had orthologs with high sequence identity in sitka (Picea sitchensis) and white (Picea glauca) spruce. Despite the conservation of STS sequences in these three spruce species, they differed substantially from angiosperm STSs. Several types of in vitro and in vivo assays revealed that the P. abies STSs catalyze the condensation of p-coumaroyl-coenzyme A and three molecules of malonyl-coenzyme A to yield the trihydroxystilbene resveratrol but do not directly form the dominant spruce stilbenes, which are tetrahydroxylated. However, in transgenic Norway spruce overexpressing PaSTS1, significantly higher amounts of the tetrahydroxystilbene glycosides, astringin and isorhapontin, were produced. This result suggests that the first step of stilbene biosynthesis in spruce is the formation of resveratrol, which is further modified by hydroxylation, O-methylation, and O-glucosylation to yield astringin and isorhapontin. Inoculating spruce with fungal mycelium increased STS transcript abundance and tetrahydroxystilbene glycoside production. Extracts from STSoverexpressing lines significantly inhibited fungal growth in vitro compared with extracts from control lines, suggesting that spruce stilbenes have a role in antifungal defense.

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“…The Rheum root ethanol extracts were analyzed for the total content of polyphenols, anthracene derivatives, anthraquinones and tannins as the main biologically active components of species from Polygonaceae family [12][13][14][15][16][18][19][20][21]. As shown in Table 1 According to our results presented in Figure 1, R. undulatum extract showed the strongest inhibitory effect on the reference strains of Staphylococcus spp.…”

Section: Resultsmentioning

confidence: 97%

“…Various species of the genus Rheum contain polyphenol components, such as anthraquinones, anthocyanins, flavonols and stilbenes, which may have bioactive properties [10,12,[17][18][19]. The medicinal use of this species is mainly related to the presence of several secondary metabolites such as anthracenes (emodin, fiscion, chrysophanol, aloe-emodin and rhein derivatives), stilbenes (resveratrol, rhapontigenin, piceatannol and its derivatives), naphtalenes and chromones, in the underground parts of the plants [16][17][18][19][20][21][22][23][24][25][26]. According to the literature [27], several bioactive anthraquinones of rhubarb posses promising anti-cancer properties with a smaller or no cytotoxic effect in several normal cells.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity and total content of polyphenols of Rheum L. species growing in Poland

2010

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Abstract:In the crude ethanol extracts obtained from the rhizome and roots of Rheum palmatum L., Rheum undulatum L. ) than against those of Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis).The strongest inhibitory effect against Staphylococcus spp. was exerted by R. undulatum extract with MIC = 125-250 μg/mL. The moderate in vitro antibacterial activity of R. undulatum suggests that this plant, often used in the European cuisine to improve flavour, may be also important and useful as an alternative or auxiliary medicine remedy in the treatment of uncomplicated superficial infections caused especially by clinically important staphylococci, potentially pathogenic S. aureus or opportunistic S. epidermidis.

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Polyphenolic composition of roots and petioles of Rheum rhaponticum L.

Cited by 44 publications

References 25 publications

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Biosynthesis of the Major Tetrahydroxystilbenes in Spruce, Astringin and Isorhapontin, Proceeds via Resveratrol and Is Enhanced by Fungal Infection

Antimicrobial activity and total content of polyphenols of Rheum L. species growing in Poland

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