Activation of Dopamine Signals in the Olfactory Tubercle Facilitates Emergence from Isoflurane Anesthesia in Mice

Yang, Bo; Ao, Yawen; Xue-fen, Zhang; Liu, Ying; Tang, Fei; Xu, Haibo

doi:10.1007/s11064-021-03291-4

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…In addition, EEG spectral analysis indicated a significant decreased in delta power, while the theta and alpha power increased during the emergence period. These results show that optical activation of dopaminergic terminals in the olfactory tubercle accelerates behavioral and cortical arousal ( Yang et al, 2021 ).…”

Section: Ventral Tegmental Areamentioning

confidence: 84%

Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics

Gao,

Wang,

Zhang

et al. 2024

Front. Pharmacol.

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For over 170 years, general anesthesia has played a crucial role in clinical practice, yet a comprehensive understanding of the neural mechanisms underlying the induction of unconsciousness by general anesthetics remains elusive. Ongoing research into these mechanisms primarily centers around the brain nuclei and neural circuits associated with sleep-wake. In this context, two sophisticated methodologies, optogenetics and chemogenetics, have emerged as vital tools for recording and modulating the activity of specific neuronal populations or circuits within distinct brain regions. Recent advancements have successfully employed these techniques to investigate the impact of general anesthesia on various brain nuclei and neural pathways. This paper provides an in-depth examination of the use of optogenetic and chemogenetic methodologies in studying the effects of general anesthesia on specific brain nuclei and pathways. Additionally, it discusses in depth the advantages and limitations of these two methodologies, as well as the issues that must be considered for scientific research applications. By shedding light on these facets, this paper serves as a valuable reference for furthering the accurate exploration of the neural mechanisms underlying general anesthesia. It aids researchers and clinicians in effectively evaluating the applicability of these techniques in advancing scientific research and clinical practice.

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Section: Ventral Tegmental Areamentioning

confidence: 84%

Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics

Gao,

Wang,

Zhang

et al. 2024

Front. Pharmacol.

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“…Activation of the RMTg, a structure with dense inhibitory projections to VTA dopamine and glutamate neurons, enhances general anesthesia [58]. Dopamine release from the VTA onto D1R-expressing neurons in the NAc [38,40 ▪▪ ,41 ▪▪ ] and OT [46] (mesolimbic pathway) or the Prl (mesocortical pathway) [47 ▪ ] has been shown to induce emergence from general anesthesia in rodent studies. Recently, D1R NAc neurons projecting to the VP and LH have been shown to both induce emergence in rodents under general anesthesia [42 ▪ ].…”

Section: Discussionmentioning

confidence: 99%

“…This node regulates odor-guided motivated behaviors via D1R- and D2R-expressing neurons [45]. While pharmacologically activating or inhibiting olfactory tubercle D1Rs via direct microinjection has no impact on isoflurane induction times in rodents, activating D1R accelerates emergence while inhibiting D1Rs delays emergence from isoflurane [46]. Furthermore, selective optogenetic stimulation of VTA dopaminergic projections to the olfactory tubercle accelerates emergence latency following isoflurane anesthesia [46].…”

Section: The Mesolimbic Pathwaymentioning

confidence: 99%

Modulating anesthetic emergence with pathway-selective dopamine signaling

Vincent

Solt

2023

Current Opinion in Anaesthesiology

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Purpose of review To summarize the recent preclinical findings investigating dopaminergic circuits for their involvement in reversing anesthetic-induced unconsciousness. Recent findings The release of dopamine from the ventral tegmental area onto dopamine D1 receptor-expressing neurons in the nucleus accumbens promotes emergence following general anesthesia. Two relevant targets of dopamine D1 receptor-expressing neurons in the nucleus accumbens include the lateral hypothalamus and ventral pallidum. Activating mesocortical dopaminergic projections from the ventral tegmental area to the prelimbic cortex has also been shown to hasten emergence from general anesthesia. In contrast, the nigrostriatal dopamine pathway is not involved in regulating anesthetic emergence. The role of the tuberoinfundibular endocrine dopamine pathway remains to be tested; however, recent studies have identified an important function of neuroendocrine signaling on modulating general anesthesia. Summary Potential avenues for accelerating anesthetic emergence may be found through targeting specific arousal-promoting pathways in the brain. Accumulating evidence from rodent studies manipulating cell type- and circuit-specific signaling pathways have identified dopamine as a potent modulator of general anesthesia. Specifically, dopamine signaling along the mesolimbic and mesocortical pathways plays a fundamental role in regulating consciousness.

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“…In addition, the olfactory nodule (OT) is intensively innervated by dopaminergic neurons of VTA, and its main neuronal components are neurons expressing D1R and D2R. Injection of D1R or D2R agonists into the OT significantly accelerates isoflurane-induced wakefulness, whereas D1R or D2R antagonists significantly delay wakefulness [ 96 ].…”

Section: Dopaminergic System For General Anesthesia Recoverymentioning

confidence: 99%

Dopaminergic System in Promoting Recovery from General Anesthesia

et al. 2023

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Dopamine is an important neurotransmitter that plays a biological role by binding to dopamine receptors. The dopaminergic system regulates neural activities, such as reward and punishment, memory, motor control, emotion, and sleep–wake. Numerous studies have confirmed that the dopaminergic system has the function of maintaining wakefulness in the body. In recent years, there has been increasing evidence that the sleep–wake cycle in the brain has similar neurobrain network mechanisms to those associated with the loss and recovery of consciousness induced by general anesthesia. With the continuous development and innovation of neurobiological techniques, the dopaminergic system has now been proved to be involved in the emergence from general anesthesia through the modulation of neuronal activity. This article is an overview of the dopaminergic system and the research progress into its role in wakefulness and general anesthesia recovery. It provides a theoretical basis for interpreting the mechanisms regulating consciousness during general anesthesia.

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Activation of Dopamine Signals in the Olfactory Tubercle Facilitates Emergence from Isoflurane Anesthesia in Mice

Cited by 6 publications

References 55 publications

Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics

Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics

Modulating anesthetic emergence with pathway-selective dopamine signaling

Dopaminergic System in Promoting Recovery from General Anesthesia

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