Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics
Hui Gao,
Jingyi Wang,
Rui Zhang
et al.
Abstract:For over 170 years, general anesthesia has played a crucial role in clinical practice, yet a comprehensive understanding of the neural mechanisms underlying the induction of unconsciousness by general anesthetics remains elusive. Ongoing research into these mechanisms primarily centers around the brain nuclei and neural circuits associated with sleep-wake. In this context, two sophisticated methodologies, optogenetics and chemogenetics, have emerged as vital tools for recording and modulating the activity of s… Show more
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